β-Lipotropin (88-91)
β-Lipotropin (88-91)
TECHNICAL SPECIFICATIONS
| Item | Specification |
|---|---|
| Product Name | β-Lipotropin (88-91) |
| CAS NO. | / |
| Appearance | White to off-white lyophilized powder |
| Molecular Formula | C19H36N6O7 |
| Molecular Weight | 460.53g/mol |
| Purity (RP-HPLC) | ≥ 95.0% |
| Solubility | Soluble in water, dilute PBS (pH 7.0-7.4), 0.1% TFA aqueous solution and DMSO. |
| Endotoxin | < 1.0 EU/mg |
| Biological Activity | Bioactive 5-mer fragment of β-Lipotropin (β-LPH), an endogenous opioid peptide precursor fragment with weak mu-opioid receptor binding activity. |
| Storage Conditions | Store at -20°C to -80°C in a sealed, dry and light-protected container; avoid repeated freeze-thaw cycles |
| Stock Location | Stock in USA |
| MOQ | 1g |
1.MECHANISM OF ACTION
The mechanism of action for this specific tetrapeptide fragment is not fully established and likely differs from the full-length β-Lipotropin. It is a constituent of the longer β-Endorphin sequence but is too short to activate opioid receptors (MOP, DOP, KOP) which require a longer peptide chain.
2.PRODUCT INDICATIONS
- Peptide Processing & Metabolism Studies: Used as a reference standard or substrate in enzymatic assays to study the proteolytic cleavage pathways that convert β-Lipotropin into β-Endorphin and other active fragments (e.g., studying prohormone convertase activity).
- Antibody Production & Epitope Mapping: Conjugating the peptide to a carrier protein to generate polyclonal or monoclonal antibodies specific to this region of β-Lipotropin/β-Endorphin. These antibodies can be used in immunoassays (ELISA, RIA, Western blot) or immunohistochemistry to detect the precursor or its products.
- Structure-Activity Relationship (SAR) Studies: Serving as a minimal reference fragment in comparative studies with longer opioid peptides (like β-Endorphin) to understand the contribution of specific sub-sequences to receptor binding, stability, and bioactivity.
3.CLINICAL EFFICACY OF PRODUCT
- Research Tool Efficacy: Its efficacy is defined by its utility as a precise molecular probe for studying the complex proteolytic processing of the POMC/β-Lipotropin system and for generating specific immunological reagents.
- Biological Significance Context: The full-length β-Lipotropin and its product, β-Endorphin, are clinically significant. β-Endorphin is a potent endogenous opioid involved in pain modulation, stress response, and reward. Understanding its biosynthesis from precursors like β-LPH is important in neuroendocrinology.
- Diagnostic Relevance: Antibodies raised against fragments like (88-91) can be used in research to develop or refine assays that measure POMC-derived peptides, which may have diagnostic implications for conditions like pituitary disorders, stress-related illnesses, or chronic pain syndromes. However, this specific fragment is not used in clinical diagnostics.
4.DELIVERY & SHIPPING
We specialize in global logistics for various cosmetic peptides. Your order will be handled with the utmost care, ensuring safe, reliable, and intact delivery.
Professional and Secure Packaging
Each bottle of peptide is protected with a special packaging solution to ensure stability and integrity during transportation.
We can also customize packaging according to customer needs.
Shipping Methods
Main Method: International Air Freight
We primarily use DHL, FedEx, UPS, and TNT because of their global reliability, speed, and advanced tracking systems. Air freight ensures the fastest transit time and minimizes the impact of environmental factors on the product.
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