Name: 10-Hydroxycamptothecin CAS 19685-09-7 - Potent Cancer Treatment
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10-Hydroxycamptothecin CAS NO.19685-09-7

10-Hydroxycamptothecin is a high-potency natural alkaloid and a key derivative of camptothecin, typically isolated from the Chinese medicinal plant Camptotheca acuminata(Happy Tree), supplied as a yellow to pale yellow crystalline powder for pharmaceutical research, API synthesis, and anticancer drug development. This bioactive quinoline alkaloid features an essential lactone ring structure that is critical for its biological activity, making it a vital intermediate for producing semi-synthetic analogs like Irinotecan and a standard reference for topoisomerase I inhibition studies. It is specifically targeted at pharmaceutical R&D departments, oncology researchers, and natural product chemists who require a reliable, high-purity agent to investigate DNA replication mechanisms, develop novel chemotherapy formulations, and validate analytical methods for camptothecin-family drugs.

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TECHNICAL SPECIFICATIONS

Item	Specification
Product Name	10-Hydroxycamptothecin
CAS NO.	19685-09-7
Appearance	Yellow to pale yellow crystalline powder
Molecular Formula	C20H16N2O5
Molecular Weight	364.35 g/mol
Purity (RP-HPLC)	≥98%
Solubility	Soluble in DMSO (with gentle warming), dilute alkali; insoluble in water, ethanol, chloroform
Endotoxin	≤10 EU/mg
Biological Activity	Exhibits strong antimicrobial, antiviral, and immunomodulatory activities; enhances wound healing and cellular defense mechanisms
Storage Conditions	Store at -20°C, protected from light and moisture
Stock Location	Stock in USA
MOQ	1g

1.MECHANISM OF ACTION

10-Hydroxycamptothecin exerts its specific cytotoxic effects by selectively binding to the enzyme DNA topoisomerase I and stabilizing the cleavable complex formed between the enzyme and DNA, which prevents the religation of single-strand breaks during the S-phase of the cell cycle. This intervention traps the topoisomerase I-DNA complex on the chromosome, leading to irreversible DNA damage, collapse of replication forks, and the subsequent accumulation of double-strand breaks as the cell attempts to replicate its genome. Ultimately, this mechanism triggers a cascade of apoptotic signaling pathways, including caspase activation and p53 upregulation, resulting in cell cycle arrest (primarily at the S/G2 boundary) and programmed cell death in rapidly proliferating malignant cells, while the integrity of its alpha-hydroxylactone ring is maintained in slightly acidic environments to ensure maximal potency.

2.PRODUCT INDICATIONS

10-Hydroxycamptothecin is indicated primarily for non-clinical oncology research and the manufacturing of chemotherapeutic agents aimed at treating a broad spectrum of solid tumors and hematological malignancies, including primary liver cancer, gastric carcinoma, head and neck squamous cell carcinoma, leukemia, and bladder cancer. It is extensively utilized by formulation scientists developing novel drug delivery systems—such as liposomes, nanoparticles, and hydrogels—designed to improve the notoriously low aqueous solubility and lactone ring stability of the compound in physiological conditions. Additionally, it serves as a critical pharmacological probe for researchers studying multidrug resistance, angiogenesis inhibition, and radiosensitization protocols, catering to professionals investigating synergistic combination therapies involving platinum-based drugs, radiotherapy, or targeted molecular inhibitors in preclinical cancer models.

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3.CLINICAL EFFICACY OF PRODUCT

10-Hydroxycamptothecin has demonstrated significant preclinical and clinical efficacy by exhibiting 2 to 30 times greater cytotoxic potency against various cancer cell lines (such as HepG2, SGC-7901, and L1210) compared to its parent compound, camptothecin, with low nanomolar IC50 values observed in several aggressive carcinoma models. In vivo xenograft studies confirm its robust tumor growth inhibition capabilities, significantly reducing tumor volume and weight in murine models of colon cancer, melanoma, and liver cancer, often with a more favorable toxicological profile and reduced severe side effects like hemorrhagic cystitis compared to camptothecin. Furthermore, clinical applications (particularly in regional markets) have validated its therapeutic value in achieving objective response rates and disease stabilization for advanced hepatocellular carcinoma and refractory gastric cancer, establishing its role as a cornerstone compound for topoisomerase I-targeted chemotherapy and ongoing anticancer drug innovation.

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4.Certificate

GlobalTech Co., Ltd. is committed to providing high-purity biotechnological peptide products, adhering strictly to quality standards and obtaining internationally recognized certifications.

Our production partners all employ GMP-compliant production systems and possess standardized quality control processes covering raw material procurement, synthesis, purification, testing, packaging, and storage. Each batch of product comes with complete documentation, including a Certificate of Analysis (COA), HPLC purity report, mass spectrometry (MS) chromatograms, and third-party testing reports available upon request.

We prioritize:

1.A rigorous quality management system

2.Batch traceability and stability data

3.Professional laboratory testing and validation

4.Compliance with international trade standards

Our commitment to quality, transparency, and regulatory compliance ensures the provision of reliable, stable, and research-grade peptide products to our global partners.

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5.DELIVERY & SHIPPING

We specialize in global logistics for various cosmetic peptides. Your order will be handled with the utmost care, ensuring safe, reliable, and intact delivery.

Professional and Secure Packaging

Each bottle of peptide is protected with a special packaging solution to ensure stability and integrity during transportation.

We can also customize packaging according to customer needs.

Shipping Methods

Main Method: International Air Freight

We primarily use DHL, FedEx, UPS, and TNT because of their global reliability, speed, and advanced tracking systems. Air freight ensures the fastest transit time and minimizes the impact of environmental factors on the product.

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Global Technology Co., Ltd. is a modern and advanced enterprise specializing in the production and export of active pharmaceutical ingredients (APIs), peptides, and plant extracts. The company invests in and collaborates closely with domestic manufacturers holding GMP, DMF, and FDA certifications, as well as laboratories at renowned universities, to meet diverse customer needs ranging from gram-level to ton-level. This enables Dejurui Pharmaceutical to provide customers with more flexible and convenient access to cost-effective, high-quality products and superior services.

We focus on the research and development and supply of high-quality chemical products, strictly adhering to international standards and quality systems. Our products are stable in performance and reliable in purity, widely used in industrial manufacturing, scientific research, and the fine chemical industry. We provide solid support at every stage with a professional and responsible attitude.

Hot Tags: 10-Hydroxycamptothecin, Hydroxycamptothecin, Topoisomerase I Inhibitor, Anticancer Alkaloid, Camptothecin Derivative, DNA Replication Inhibitor, API Intermediate, Oncology Research, Irinotecan Precursor, Camptotheca Acuminata, Cytotoxic Agent, S-Phase Arrest, Natural Product, Chemotherapy Development

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