14Deoxyandrographolide CAS 4176970 China Suppliers and Factory
14-Deoxyandrographolide (CAS NO. 4176-97-0) is a high-purity labdane-type diterpenoid lactone derived from Andrographis paniculata. As a potent bioactive compound, it is extensively utilized in non-clinical research to explore its multi-faceted pharmacological properties, including significant anti-inflammatory, hepatoprotective, antidiabetic, and anticancer activities. Its ability to modulate intracellular signaling cascades makes it an indispensable tool for researchers in oncology and endocrinology.
Our premium grade 14-Deoxyandrographolide is synthesized and purified to ensure a purity level of ≥98.0% (RP-HPLC), providing consistent and reliable results for complex biological assays. Whether used as a primary reference standard for chromatographic analysis or as a lead compound for drug discovery involving AMPK activation and calcium channel modulation, this product meets the stringent requirements of global biotechnology laboratories and pharmaceutical research institutions.
Detailed Parameters
| Product Name | 14-Deoxyandrographolide | CAS NO. | 4176-97-0 |
|---|---|---|---|
| Appearance | White to off-white crystalline powder | Molecular Formula | C20H30O4 |
| Molecular Weight | 334.45 g/mol | Purity (RP-HPLC) | ≥98.0% |
| Solubility | Soluble in DMSO, Methanol, Ethanol, Chloroform | Endotoxin | < 10 EU/mg |
| Storage Conditions | Store at -20°C, protected from light/moisture | MOQ | 1g |
Key Advantages
Ultra-High Purity
Guaranteed ≥98.0% purity via RP-HPLC, ensuring high precision in quantitative analysis and biological assays.
AMPK Activation
Potently activates AMPK via the cAMP-PKA pathway to regulate lipid metabolism and glucose uptake.
Cancer Research
Demonstrates selective cytotoxicity against HL-60 and T47D cancer cells, acting as a potent apoptosis inducer.
Hepatoprotective
Mitigates ethanol-induced liver injury by down-regulating lipogenic enzymes and restoring GSH levels.
Metabolic Control
Improves insulin sensitivity and enhances GLUT4 membrane translocation in diabetic models.
Full Traceability
Each batch is accompanied by a COA, HPLC report, and MS chromatograms for complete quality validation.
Product Gallery
Management Platforms
GMP Compliance
Production adheres to strict GMP standards for pharmaceutical raw materials and APIs.
Quality Control
Rigorous testing processes covering procurement, synthesis, purification, and stability.
Rapid Logistics
Expedited global shipping via DHL, FedEx, and UPS with real-time advanced tracking.
Cold Chain Care
Specialized packaging to maintain stability at -20°C during international transit.
Scalable Supply
Flexible supply capacity ranging from gram-level research to ton-level industrial production.
Academic Synergy
Close collaboration with top university labs to ensure the latest research-grade specifications.
Investment Return Comparison
| Evaluation Metric | Standard Grade | Our Premium Grade |
|---|---|---|
| Purity Level | < 95% | ≥ 98.0% (HPLC) |
| Documentation | Basic COA | COA + HPLC + MS Report |
| Stability Data | Limited | Comprehensive Batch Traceability |
| Delivery Speed | Standard Mail | Express Air Freight (DHL/FedEx) |
| Research Reliability | Variable | High Reproducibility |
Frequently Asked Questions
It is primarily used in oncology for studying apoptosis in cancer cells, in hepatology for liver protection research, and in endocrinology to investigate glucose uptake and insulin sensitivity.
The product should be stored at -20°C in a tightly sealed container, protected from exposure to light and moisture to prevent degradation.
Yes, due to its high purity (≥98%), it is widely used as a primary reference standard for the quantitative analysis of Andrographis paniculata extracts.
It is soluble in DMSO, Methanol, Ethanol, and Chloroform, but it is insoluble in water.
Our partners employ GMP-compliant production systems and adhere to international trade standards, providing full COA and HPLC purity reports.
Yes, we provide customized packaging solutions according to specific customer needs to ensure stability and compliance during transport.
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