2-Desoxy-4-epi-pulchellin CAS NO.122872-03-1

2-Desoxy-4-epi-pulchellin CAS NO.122872-03-1

2-Desoxy-4-epi-pulchellin CAS NO.122872-03-1

2-Desoxy-4-epi-pulchellin CAS NO.122872-03-1

2-Desoxy-4-epi-pulchellin CAS NO.122872-03-1

2-Desoxy-4-epi-pulchellin (PCL) is a natural sesquiterpene lactone compound primarily extracted from medicinal plants such as Polygonum hydropiperand Carpesium abrotanoides. As a high-purity small molecule chemical reagent, it is widely used in preclinical research stages including cancer biology, immunology, and antiviral studies. This product is intended for research use only (RUO) and is strictly for laboratory purposes such as cell experiments, mechanism validation, and drug discovery screening, not for human consumption or clinical treatment.



TECHNICAL SPECIFICATIONS


Item
Specification
Product Name
2-Desoxy-4-epi-pulchellin
CAS NO.
122872-03-1
Appearance
White to off-white powder
Molecular Formula
C15H22O3
Molecular Weight
250.33 g/mol
Purity (RP-HPLC)
≥ 98.0%
Solubility

Soluble in DMSO, methanol; sparingly soluble in ethanol; insoluble in water

Endotoxin< 1.0 EU/mg
Biological Activity
Inhibits JAK2/STAT3 pathway; induces apoptosis in cancer cell lines; anti-inflammatory potential
Storage Conditions
Store at -20°C, protected from light and moisture
Stock Location
Stock in USA
MOQ
1g


1.MECHANISM OF ACTION

The compound exerts its potent biological activity primarily through its α-methylene-γ-lactone functional group, which acts as a Michael acceptor capable of covalently binding to thiol groups in proteins, thereby inhibiting key signaling pathways. Its core mechanism involves the suppression of the JAK2/STAT3 signaling axis, leading to cell cycle arrest at the G2/M phase and induction of apoptosis in cancer cells. Additionally, it modulates inflammatory responses by targeting Toll-like receptor 4 (TLR4) and downstream NF-κB pathways, reducing the production of pro-inflammatory cytokines such as TNF-α and IL-6.

upload/attachment/image/202603/30/17748605359f2fcb1659519947937e881fa30fee1c_local.png

2.PRODUCT INDICATIONS

This product is indicated for scientific research applications focusing on oncology and immunology. It serves as a key reference standard and active ingredient in studies related to colorectal cancer, breast cancer, and leukemia, where it is used to investigate tumor cell proliferation inhibition and chemosensitization effects. Furthermore, it is applied in anti-inflammatory and immunomodulatory research models, including rheumatoid arthritis and multiple sclerosis, as well as in antiviral studies targeting influenza A viruses (H1N1/H3N2), making it suitable for pharmacology and new drug development research.upload/attachment/image/202603/30/1774860545ffe29baa6cedf27421185a1efbf727b5_local.png

3.CLINICAL EFFICACY OF PRODUCT

Current efficacy data for 2-Desoxy-4-epi-pulchellin are derived from in vitro and animal model studies, showing promising antitumor and anti-inflammatory potential. In cellular assays, it demonstrates cytotoxic effects against a range of cancer cell lines (e.g., HCT-116, MCF-7, A549) with IC50 values typically in the low micromolar range. In vivo studies report synergistic effects when combined with chemotherapeutic agents like 5-FU, enhancing tumor growth inhibition in colorectal cancer models. While preclinical results are robust, the product remains in the research phase and has not yet advanced to human clinical trials.

4.Certificate

GlobalTech Co., Ltd. is committed to providing high-purity biotechnological peptide products, adhering strictly to quality standards and obtaining internationally recognized certifications.


Our production partners all employ GMP-compliant production systems and possess standardized quality control processes covering raw material procurement, synthesis, purification, testing, packaging, and storage. Each batch of product comes with complete documentation, including a Certificate of Analysis (COA), HPLC purity report, mass spectrometry (MS) chromatograms, and third-party testing reports available upon request.


We prioritize:

1.A rigorous quality management system

2.Batch traceability and stability data

3.Professional laboratory testing and validation

4.Compliance with international trade standards


Our commitment to quality, transparency, and regulatory compliance ensures the provision of reliable, stable, and research-grade peptide products to our global partners.

upload/attachment/image/202603/11/17731937213fbed5ed3f3869d1613bb629f6365f21_local.png


5.DELIVERY & SHIPPING

We specialize in global logistics for various cosmetic peptides. Your order will be handled with the utmost care, ensuring safe, reliable, and intact delivery.

Professional and Secure Packaging

Each bottle of peptide is protected with a special packaging solution to ensure stability and integrity during transportation.

We can also customize packaging according to customer needs.

Shipping Methods 

Main Method: International Air Freight

We primarily use DHL, FedEx, UPS, and TNT because of their global reliability, speed, and advanced tracking systems. Air freight ensures the fastest transit time and minimizes the impact of environmental factors on the product.

upload/attachment/image/202601/20/1768872924be74a0641f7ddbf20e541c97f2066c5c_local.jpg


Global Technology Co., Ltd. is a modern and advanced enterprise specializing in the production and export of active pharmaceutical ingredients (APIs), peptides, and plant extracts. The company invests in and collaborates closely with domestic manufacturers holding GMP, DMF, and FDA certifications, as well as laboratories at renowned universities, to meet diverse customer needs ranging from gram-level to ton-level. This enables Dejurui Pharmaceutical to provide customers with more flexible and convenient access to cost-effective, high-quality products and superior services.


We focus on the research and development and supply of high-quality chemical products, strictly adhering to international standards and quality systems. Our products are stable in performance and reliable in purity, widely used in industrial manufacturing, scientific research, and the fine chemical industry. We provide solid support at every stage with a professional and responsible attitude.


Hot Tags:2-Desoxy-4-epi-pulchellin, sesquiterpene lactone, STAT3 inhibitor, JAK2/STAT3 pathway, anticancer research, anti-inflammatory, natural product, research chemical, preclinical candidate, RUO, chemical reagent, PCL compound, Supplier, Manufacturer, Bulk order,  Pharmaceutical.


If you have any product requirements, please send an email to:info@huanqiukeji9.com;whatsapp:85246842553

Global Market Analysis and Oxandrolone 50mg Price Guide
Nov 05, 26
Global Market Analysis and Oxandrolone 50mg Price Guide
For B2B pharmaceutical buyers and researchers, understanding the oxandrolone 50mg price involves analyzing more than just a numerical value; it requires a comprehensive look at API purity, synthesis methods, and global supply chain stability. As a specialized anabolic steroid derivative, the cost is heavily influenced by the quality of raw materials and the rigor of the laboratory testing involved in the production process. This article explores the economic and technical variables that dictate market pricing for this specific compound. In the context of the global API market, pricing volatility is often tied to regulatory shifts in key manufacturing hubs
How to Select High Purity Alisol C CAS 30489271 for Laboratory Research
Nov 04, 26
How to Select High Purity Alisol C CAS 30489271 for Laboratory Research
High Purity Alisol C CAS 30489271 is suited to laboratories using Alisol C as a triterpenoid reference standard in metabolic, hepatology, pharmacology, HPLC/MS, botanical-extract, or selected cell-line research. We explain the application fit and the identity, purity, physical form, solvent, endotoxin, storage, quantity, and batch-record checks to make before ordering.
Reliable Oxandrolone Supplier for High Purity Pharmaceutical APIs
Nov 02, 26
Reliable Oxandrolone Supplier for High Purity Pharmaceutical APIs
When sourcing high-purity pharmaceutical ingredients for endocrine or cardiovascular research, the reliability of the supply chain is as critical as the chemical purity itself. For laboratories and manufacturers seeking a dependable oxandrolone supplier, the focus must extend beyond simple certificates of analysis to encompass consistent batch-to-batch stability and strict adherence to GMP standards. Whether the requirement is for small-scale pilot studies or large-scale industrial production, the ability to trace materials from raw synthesis to final lyophilized powder ensures the integrity of the resulting clinical or research data.

If you are interested in our products, you can choose to leave your information here, and we will be in touch with you shortly.