Name: 2,3,4,5-Tetracaffeoyl-D-Glucaric acid CAS NO.1419478-52-6
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2,3,4,5-Tetracaffeoyl-D-Glucaric acid CAS NO.1419478-52-6

2,3,4,5-Tetracaffeoyl-D-Glucaric acid is a high-purity polyphenolic compound and a naturally occurring caffeoyl-D-glucaric acid derivative, typically isolated from medicinal plants such as Inula japonicaor Gnaphaliumspecies, supplied as an off-white to light yellow powder for advanced pharmacological and phytochemical research. This structurally complex molecule features a D-glucaric acid backbone esterified with four caffeoyl groups, making it a critical reference standard for scientists studying natural antioxidants, oxidative stress modulators, and anti-adipogenic agents. It is specifically tailored for research institutions, nutraceutical developers, and biochemical laboratories requiring a reliable, high-quality reagent to investigate free radical scavenging capacities, lipid metabolism regulation, and cellular protective mechanisms against inflammatory insults.

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TECHNICAL SPECIFICATIONS

Item	Specification
Product Name	2,3,4,5-Tetracaffeoyl-D-Glucaric
CAS NO.	1419478-52-6
Appearance	Brown to dark brown amorphous powder
Molecular Formula	C42H34O20
Molecular Weight	858.71g/mol
Purity (RP-HPLC)	≥95%
Solubility	Soluble in 1M acetic acid, DMSO, or deionized water
Endotoxin	< 10 EU/mg
Biological Activity	Exhibits strong antioxidant activity due to multiple caffeoyl groups; potential anti-inflammatory and hepatoprotective effects; commonly found in plants like Eucalyptus globulus.
Storage Conditions	Store at -20°C, protected from light and moisture. Keep container tightly sealed.
Stock Location	Stock in USA
MOQ	1g

1.MECHANISM OF ACTION

2,3,4,5-Tetracaffeoyl-D-Glucaric acid exerts its primary biological effects by acting as a potent inhibitor of reactive oxygen species (ROS) production, particularly in fMLP-stimulated human neutrophils, where it disrupts the oxidative burst and neutralizes free radicals through its high-density phenolic hydroxyl groups. The compound actively scavenges superoxide anions and peroxynitrite while chelating pro-oxidant metal ions, thereby preventing the initiation and propagation of lipid peroxidation chains that damage cellular membranes and DNA. Furthermore, it interferes with adipogenic differentiation at the molecular level by modulating key transcriptional regulators, suppressing the accumulation of lipid droplets in preadipocytes, and inhibiting the expression of mature fat cell markers, which collectively shift the cellular environment from a pro-oxidative and fat-storing state to a protected and metabolically balanced state.

2.PRODUCT INDICATIONS

2,3,4,5-Tetracaffeoyl-D-Glucaric acid is indicated for non-clinical research applications in the fields of obesity and metabolic disorder studies, where it serves as a vital tool for evaluating anti-adipogenic drug candidates and understanding the biochemical pathways of fat accumulation reduction. It is extensively used by dermatological researchers and cosmetic chemists to assess anti-skin aging effects, particularly in TNF-α-induced fibroblast damage models, and by immunologists investigating the modulation of neutrophil hyperactivity and inflammatory signaling cascades. Additionally, this product is essential for phytochemists and analytical chemists who require a primary standard for HPLC and mass spectrometry method development to quantify bioactive phenolics in herbal extracts, catering to professionals exploring natural preservatives, dietary supplement ingredients, and plant-derived therapeutic agents.

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3.CLINICAL EFFICACY OF PRODUCT

2,3,4,5-Tetracaffeoyl-D-Glucaric acid has demonstrated significant efficacy in preclinical models by substantially reducing intracellular ROS levels and protecting normal human fibroblasts from cytokine-induced damage, showcasing its potential in mitigating premature skin aging and environmental stress at the cellular level. In adipogenesis assays, the compound effectively inhibits triglyceride accumulation in differentiating preadipocytes and reduces body fat parameters in relevant obesity research models, often outperforming simpler mono- or di-caffeoyl derivatives due to its tetra-substituted structure. These findings confirm its robust capacity to enhance cellular antioxidant defenses, preserve mitochondrial integrity under stress conditions, and regulate lipid homeostasis, establishing it as a compound with notable bioactive potential for ongoing pharmacological validation and mechanistic studies in oxidative stress-related pathologies.

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4.Certificate

GlobalTech Co., Ltd. is committed to providing high-purity biotechnological peptide products, adhering strictly to quality standards and obtaining internationally recognized certifications.

Our production partners all employ GMP-compliant production systems and possess standardized quality control processes covering raw material procurement, synthesis, purification, testing, packaging, and storage. Each batch of product comes with complete documentation, including a Certificate of Analysis (COA), HPLC purity report, mass spectrometry (MS) chromatograms, and third-party testing reports available upon request.

We prioritize:

1.A rigorous quality management system

2.Batch traceability and stability data

3.Professional laboratory testing and validation

4.Compliance with international trade standards

Our commitment to quality, transparency, and regulatory compliance ensures the provision of reliable, stable, and research-grade peptide products to our global partners.

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5.DELIVERY & SHIPPING

We specialize in global logistics for various cosmetic peptides. Your order will be handled with the utmost care, ensuring safe, reliable, and intact delivery.

Professional and Secure Packaging

Each bottle of peptide is protected with a special packaging solution to ensure stability and integrity during transportation.

We can also customize packaging according to customer needs.

Shipping Methods

Main Method: International Air Freight

We primarily use DHL, FedEx, UPS, and TNT because of their global reliability, speed, and advanced tracking systems. Air freight ensures the fastest transit time and minimizes the impact of environmental factors on the product.

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Global Technology Co., Ltd. is a modern and advanced enterprise specializing in the production and export of active pharmaceutical ingredients (APIs), peptides, and plant extracts. The company invests in and collaborates closely with domestic manufacturers holding GMP, DMF, and FDA certifications, as well as laboratories at renowned universities, to meet diverse customer needs ranging from gram-level to ton-level. This enables Dejurui Pharmaceutical to provide customers with more flexible and convenient access to cost-effective, high-quality products and superior services.

We focus on the research and development and supply of high-quality chemical products, strictly adhering to international standards and quality systems. Our products are stable in performance and reliable in purity, widely used in industrial manufacturing, scientific research, and the fine chemical industry. We provide solid support at every stage with a professional and responsible attitude.

Hot Tags: 2,3,4,5-Tetracaffeoyl-D-Glucaric acid, Tetracaffeoylglucaric Acid, Polyphenol, Antioxidant, Anti-adipogenic, ROS Inhibitor, Inula Japonica, Natural Product, Phytochemical, Research Standard, Free Radical Scavenger, Phenolic Compound, D-Glucaric Acid Derivative, Obesity Research

If you have any product requirements, please send an email to:consult@huanqiukeji9.com ;whatsapp: 686532411