Name: High-Purity ACTH (1-39), Rat - CAS 77465-10-2 for Research
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ACTH (1-39), rat CAS NO.77465-10-2

ACTH (1-39), rat is a synthetic replicate of the full-length adrenocorticotropic hormone naturally secreted by the anterior pituitary gland in rodents, specifically designed for comparative endocrinology and veterinary research. This peptide serves as a critical research tool for studying adrenal gland function, steroidogenesis, and the physiological stress response in rat models, offering high biological relevance for species-specific investigations. Researchers utilize this reagent to explore hypothalamic-pituitary-adrenal axis dynamics and to evaluate the impact of hormonal regulation on metabolism and immune function in preclinical settings.

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TECHNICAL SPECIFICATIONS

Item	Specification
Product Name	ACTH (1-39), rat
CAS NO.	77465-10-2
Appearance	White to off-white lyophilized powder
Molecular Formula	C₂₁₀H₃₁₅N₅₇O₅₇S
Molecular Weight	~4582.3 g/mol
Purity (RP-HPLC)	≥98%
Solubility	Soluble in 1M acetic acid, DMSO, or deionized water
Endotoxin	≤1 EU/mg
Biological Activity	Potent stimulator of adrenal cortisol secretion; activates melanocortin receptors (MC2R primarily)
Storage Conditions	Store at -20°C, protected from light and moisture
Stock Location	Stock in USA
MOQ	1g

1.MECHANISM OF ACTION

The peptide exerts its primary physiological effects by binding to the melanocortin type 2 receptor (MC2R), which is predominantly expressed on adrenal cortical cells, triggering a Gs-protein coupled signaling cascade that stimulates adenylate cyclase activity. This leads to a significant increase in intracellular cyclic AMP (cAMP) levels, which subsequently activates protein kinase A (PKA) and promotes the synthesis and release of glucocorticoids such as cortisol. Additionally, ACTH can interact with other melanocortin receptors (MC1R, MC3R-MC5R) at higher concentrations, influencing pigmentation, energy homeostasis, and anti-inflammatory processes, although its principal action remains focused on adrenal stimulation.

2.PRODUCT INDICATIONS

This product is specifically indicated for use in in vitro and in vivo research applications focused on neuroendocrinology, endocrinology, and stress physiology within rat models. It is suitable for scientists investigating adrenal insufficiency, Cushing's syndrome, and the pharmacological effects of corticosteroids. Furthermore, it serves as an essential reagent for developing assays related to pituitary function, exploring the molecular mechanisms of hormone secretion, and conducting preclinical studies aimed at understanding metabolic disorders, obesity, and immune modulation mediated by the adrenal glands.

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3.CLINICAL EFFICACY OF PRODUCT

While not intended for human clinical use, ACTH (1-39), rat demonstrates high efficacy in preclinical models for validating the functional integrity of the HPA axis and assessing adrenal steroidogenic capacity. Its application in animal studies provides robust data on the kinetics of cortisol release in response to pituitary stimulation, aiding in the development of diagnostic tools and therapeutic strategies for adrenal disorders. The peptide's reliability in inducing consistent physiological responses makes it invaluable for evaluating the efficacy of potential steroidogenic drugs and for establishing baseline parameters in transgenic or knockout rodent studies.

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4.Certificate

GlobalTech Co., Ltd. is committed to providing high-purity biotechnological peptide products, adhering strictly to quality standards and obtaining internationally recognized certifications.

Our production partners all employ GMP-compliant production systems and possess standardized quality control processes covering raw material procurement, synthesis, purification, testing, packaging, and storage. Each batch of product comes with complete documentation, including a Certificate of Analysis (COA), HPLC purity report, mass spectrometry (MS) chromatograms, and third-party testing reports available upon request.

We prioritize:

1.A rigorous quality management system

2.Batch traceability and stability data

3.Professional laboratory testing and validation

4.Compliance with international trade standards

Our commitment to quality, transparency, and regulatory compliance ensures the provision of reliable, stable, and research-grade peptide products to our global partners.

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5.DELIVERY & SHIPPING

We specialize in global logistics for various cosmetic peptides. Your order will be handled with the utmost care, ensuring safe, reliable, and intact delivery.

Professional and Secure Packaging

Each bottle of peptide is protected with a special packaging solution to ensure stability and integrity during transportation.

We can also customize packaging according to customer needs.

Shipping Methods

Main Method: International Air Freight

We primarily use DHL, FedEx, UPS, and TNT because of their global reliability, speed, and advanced tracking systems. Air freight ensures the fastest transit time and minimizes the impact of environmental factors on the product.

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Global Technology Co., Ltd. is a modern and advanced enterprise specializing in the production and export of active pharmaceutical ingredients (APIs), peptides, and plant extracts. The company invests in and collaborates closely with domestic manufacturers holding GMP, DMF, and FDA certifications, as well as laboratories at renowned universities, to meet diverse customer needs ranging from gram-level to ton-level. This enables Dejurui Pharmaceutical to provide customers with more flexible and convenient access to cost-effective, high-quality products and superior services.

We focus on the research and development and supply of high-quality chemical products, strictly adhering to international standards and quality systems. Our products are stable in performance and reliable in purity, widely used in industrial manufacturing, scientific research, and the fine chemical industry. We provide solid support at every stage with a professional and responsible attitude.

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