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[Ala286]-Calmodulin-Dependent Protein Kinase II (281-302) ((Ala286)-CaMK-II (281-302)) CAS NO.141055-85-8
TECHNICAL SPECIFICATIONS
| Item | Specification |
|---|---|
| Product Name | [Ala²⁸⁶]-Calmodulin-Dependent Protein Kinase II (281-302) ((Ala²⁸⁶)-CaMK-II (281-302)) |
| CAS NO. | 141055-85-8 |
| Appearance | White to off-white lyophilized powder |
| Molecular Formula | C111H191N39O29S2 |
| Molecular Weight | 2600.12/mol |
| Amino Acid Sequence | Ac-RQEITVKKLKQLKTNLLIAKTVAEGLAQET-NH₂ (human CaMK-II residues 281–302 with Ala substitution at position corresponding to 286; actual position numbering may vary) |
| Purity (RP-HPLC) | ≥95.0% |
| Solubility | Soluble in water, PBS, or dilute acetic acid solution; may require brief sonication |
| Endotoxin | ≤1.0 EU/mg |
| Biological Activity | Synthetic peptide with Ala substitution at position 286; used as a substrate, inhibitor, or tool in CaMK-II activity studies, calcium/calmodulin signaling research, and neurological/cardiovascular disease models. |
| Storage Conditions | Store at –20°C, protected from light and moisture. For long-term storage, recommend –80°C. |
| Stock Location | Stock in USA |
| MOQ | 10mg |
1.MECHANISM OF ACTION
This peptide acts as a substrate or modulator for CaMK-II, a key enzyme in calcium/calmodulin signaling. Its sequence, containing a specific alanine substitution at position 286, is used to probe phosphorylation events, enzyme kinetics, and the structural determinants of CaMK-II activity in cellular regulation.
2.PRODUCT INDICATIONS
[Ala²⁸⁶]-CaMK-II (281-302) is primarily used in kinase activity assays, signal transduction research, and studies of neuronal and cardiac function. It is a critical tool for investigating the role of CaMK-II in synaptic plasticity, gene expression, and disease models associated with calcium signaling dysregulation.
3.CLINICAL EFFICACY OF PRODUCT
As a research tool, this peptide itself is not intended for clinical use. Its efficacy lies in enabling foundational and translational studies that elucidate the molecular mechanisms of CaMK-II, thereby contributing to the understanding and potential future treatment of neurological, cardiovascular, and metabolic disorders.
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