Amylin (8-37), human CAS NO.135702-23-7
Amylin (8-37), human CAS NO.135702-23-7
TECHNICAL SPECIFICATIONS
| Item | Specification |
|---|---|
| Product Name | Amylin (8-37) |
| CAS NO. | 135702-23-7 |
| Appearance | White to off-white lyophilized powder |
| Molecular Formula | C₁₃₈H₂₁₆N₄₂O₄₅ |
| Molecular Weight | 3183.48g/mol |
| Purity (RP-HPLC) | ≥ 95.0% |
| Solubility | Soluble in water (5 mg/mL) or 5% acetic acid; also soluble in DMSO |
| Endotoxin | < 1.0 EU/mg |
| Biological Activity | A 30-amino acid fragment of human amylin, acting as an amylin receptor antagonist; binds to amylin receptors without agonist activity, inhibits full-length amylin-induced effects, and has direct vasodilator effects in isolated mesenteric resistance arteries. |
| Storage Conditions | -20°C for long-term storage ; avoid repeated freeze-thaw cycles. Store as aliquots in sealed vials. |
| Stock Location | Stock in USA |
| MOQ | 1g |
1.MECHANISM OF ACTION
Amylin (8-37) functions as a competitive receptor antagonist:
- Receptor Binding: The fragment retains the core structural region necessary for high-affinity binding to the amylin receptor (a complex of the Calcitonin Receptor (CTR) and Receptor Activity-Modifying Proteins (RAMPs)).
- Lack of Agonist Activity: Unlike full-length amylin, the truncated (8-37) fragment does not activate the receptor's signaling cascade. It occupies the receptor's binding site.
- Inhibition of Endogenous Amylin: By occupying the receptor, it competitively inhibits the binding and action of endogenous, full-length amylin. This prevents amylin-induced effects such as inhibition of glucagon secretion, slowing of gastric emptying, and promotion of satiety.
2.PRODUCT INDICATIONSSpecificity: It is a relatively selective antagonist for the amylin receptor at appropriate concentrations, allowing researchers to isolate amylin-mediated effects from those of related hormones like calcitonin.
This product is indicated for advanced pharmacological and physiological research aimed at defining the specific contributions of amylin signaling. Key applications include:
- Pharmacological Antagonism Studies: To block endogenous or exogenous amylin action in order to confirm the involvement of the amylin pathway in a observed biological effect (e.g., in feeding, glucose regulation, or gastric motility experiments).
- Receptor Characterization: As a tool to define the binding and functional properties of amylin receptors in cell-based assays and tissue preparations.
- Metabolism & Diabetes Research: To investigate the physiological consequences of acute amylin deficiency in animal models, helping to understand its role in glucose homeostasis.
- Obesity & Feeding Studies: To antagonize the satiety effect of amylin, thereby increasing food intake, which helps quantify amylin's contribution to appetite control.
- Specificity Control: To differentiate effects mediated by the amylin receptor from those of other receptors (e.g., calcitonin or CGRP receptors) when using related peptides.
3.CLINICAL EFFICACY OF PRODUCT
Amylin (8-37), human is a research tool, not a therapeutic. Its "clinical efficacy" lies in its pivotal role in preclinical validation science.
- Critical for Target Validation: The ability to specifically block amylin's action with this antagonist has been instrumental in proving that the physiological effects (e.g., reduced food intake, lowered glucagon) observed with amylin or its analogs (like pramlintide) are specifically mediated through the amylin receptor. This is a fundamental step in drug discovery.
- Enabling Mechanistic Insights: Its use in research has allowed scientists to dissect the complex hormonal control of metabolism, definitively attributing specific functions to amylin signaling. This rigorous mechanistic understanding underpins the rationale for using amylin analogs in therapy.
- Foundational for Drug Development: Data generated using this antagonist helped build the robust pharmacological profile of the amylin system, supporting the development and FDA approval of the amylin analog pramlintide for diabetes treatment.
4.DELIVERY & SHIPPING
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