Amylin,human CAS NO.122384-88-7
Amylin,human CAS NO.122384-88-7
TECHNICAL SPECIFICATIONS
| Item | Specification |
|---|---|
| Product Name | Amylin, human |
| CAS NO. | 122384-88-7 |
| Appearance | White to off-white lyophilized powder |
| Molecular Formula | C₁₆₅H₂₆₁N₅₁O₅₅S₂ |
| Molecular Weight | 1067.21 g/mol |
| Purity (RP-HPLC) | ≥ 95.0% |
| Solubility | Soluble in water (5 mg/mL) or 5% acetic acid; also soluble in DMSO |
| Endotoxin | < 1.0 EU/mg |
| Biological Activity | Endogenous peptide agonist for amylin, calcitonin, CGRP, and adrenomedullin receptors; inhibits glucagon secretion, delays gastric emptying, and acts as a satiety agent with glucose-lowering effects in vivo. |
| Storage Conditions | 20°C for long-term storage ; avoid repeated freeze-thaw cycles. Store as aliquots in sealed vials. |
| Stock Location | Stock in USA |
| MOQ | 1g |
1.MECHANISM OF ACTION
Amylin exerts its physiological effects primarily by activating specific amylin receptors, which are complexes of the Calcitonin Receptor (CTR) and Receptor Activity-Modifying Proteins (RAMPs). Its key mechanisms include:
- Inhibition of Glucagon Secretion: Amylin acts on the pancreas to suppress postprandial glucagon secretion from α-cells, reducing hepatic glucose production.
- Slowing of Gastric Emptying: It acts centrally via receptors in the area postrema to delay the rate of gastric emptying, which moderates the post-meal rise in blood glucose.
- Promotion of Satiety: By signaling to the brain (particularly the hindbrain and hypothalamus), amylin induces a feeling of fullness (satiety), leading to reduced food intake.
- Potential Pathological Aggregation: In type 2 diabetes, human amylin can form toxic oligomers and amyloid fibrils, which contribute to β-cell dysfunction and apoptosis—a process actively studied in diabetes research.
2.PRODUCT INDICATIONS
This product is indicated for advanced research in endocrinology, diabetes, metabolism, and neuroscience. Key applications include:
- Diabetes & Metabolism Research: Studying the role of amylin in normal glucose homeostasis and its dysfunction in type 1 and type 2 diabetes.
- Obesity & Satiety Studies: Investigating its anorexigenic effects and potential as a target for weight management.
- Amyloid & Protein Aggregation Research: As a model peptide for studying the mechanisms of amyloid formation, β-cell toxicity, and its link to diabetes pathology.
- Pharmacology & Drug Discovery: Serving as a reference compound for screening and developing amylin receptor agonists or analogs (e.g., pramlintide).
- Physiological Studies: Research on gastrointestinal motility and hormonal cross-talk in metabolism.
3.CLINICAL EFFICACY OF PRODUCT
Human amylin itself is not used therapeutically due to its propensity to aggregate and poor solubility. However, its clinical significance is profound:
- Therapeutic Analog (Pramlintide): The knowledge of amylin's physiology directly led to the development of pramlintide, a stable, non-aggregating analog. Pramlintide is an FDA-approved adjunct therapy for type 1 and type 2 diabetes. It effectively:
- Reduces postprandial blood glucose levels.
- Lowers HbA1c.
- Promotes weight loss by enhancing satiety.
- Biomarker & Pathological Role: Amylin (IAPP) is a key biomarker and pathological agent in diabetes research. Studying this peptide is essential for understanding disease mechanisms and identifying new therapeutic strategies.
4.DELIVERY & SHIPPING
We specialize in global logistics for various cosmetic peptides. Your order will be handled with the utmost care, ensuring safe, reliable, and intact delivery.
Professional and Secure Packaging
Each bottle of peptide is protected with a special packaging solution to ensure stability and integrity during transportation.
We can also customize packaging according to customer needs.
Shipping Methods
Main Method: International Air Freight
We primarily use DHL, FedEx, UPS, and TNT because of their global reliability, speed, and advanced tracking systems. Air freight ensures the fastest transit time and minimizes the impact of environmental factors on the product.
May 25, 26
Premium API Oxandrolone Ucinky Manufacturing
Premium API Oxandrolone Ucinky Manufacturing Leading global supplier of high-purity chemical raw materials for pharmaceutical grade Oxandrolone Ucinky, combining precision engineering with industrial scale. 5000 kg Annual Output 120 Countries Served 5 Days Sample Lead Time 99.7 On-Time Delivery Industrial Precision Pure Chemical Synthesis Engineering the future of pharmaceutical intermediates with unmatched stability. Our facility stands as a global leader in the oxandrolone ucinky sector, utilizing CRYOGENIC CRYSTALLIZATION and advanced chromatography to ensure an assay purity exceeding 99.8. We integrate a fully automated closed-loop system that eliminates human error and contamination.
May 22, 26
Clinical Benefits and Applications of Oxandrolone Therapy
Oxandrolone therapy represents a sophisticated intersection of endocrine science and regenerative medicine, primarily utilized to address muscle wasting and metabolic dysfunction. In the global pharmaceutical landscape, this specific approach to androgen therapy is valued for its unique ability to promote protein synthesis while exhibiting a lower androgenic profile compared to traditional steroids, making it a critical tool for patients recovering from severe trauma or chronic illness. From a clinical perspective, understanding the nuances of oxandrolone therapy is essential for optimizing patient outcomes in weight gain and tissue repair.
May 20, 26
Clinical Benefits and Production of Oxandrolone Steroid
The global pharmaceutical landscape has seen a significant rise in the demand for highly specialized anabolic agents, among which the oxandrolone steroid stands out due to its unique chemical profile and therapeutic versatility. As a modified version of dihydrotestosterone, this compound provides a potent means of addressing muscle wasting and metabolic deficits, making it a critical asset in both clinical rehabilitation and advanced physiological research. Understanding the nuances of this synthetic compound is essential for healthcare providers and researchers alike, as it balances efficacy with a relatively lower androgenic profile compared to other steroids.
