Angiotensin I CAS NO.34273-12-6
Angiotensin I CAS NO.34273-12-6
TECHNICAL SPECIFICATIONS
| Item | Specification |
|---|---|
| Product Name | Angiotensin I |
| CAS NO. | 34273-12-6 |
| Appearance | White to off-white lyophilized powder |
| Molecular Formula | C₆₂H₉₀N₁₈O₁₄ |
| Molecular Weight | 1293.50g/mol |
| Purity (RP-HPLC) | ≥ 95.0% |
| Solubility | Soluble in water, 0.1 M acetic acid, and DMSO |
| Endotoxin | < 1.0 EU/mg |
| Biological Activity | The inactive precursor of angiotensin II. Cleaved by angiotensin-converting enzyme (ACE) to form angiotensin II. |
| Storage Conditions | -20°C for short-term; -80°C for long-term storage. Protect from light and moisture. Avoid repeated freeze-thaw cycles. |
| Stock Location | Stock in USA |
| MOQ | 1g |
1.MECHANISM OF ACTION
Angiotensin I itself possesses minimal biological activity. Its primary role is to act as a substrate in a critical enzymatic cascade:
- Generation: It is produced in the blood by the enzymatic action of renin (released from the kidneys) on the liver-synthesized precursor, angiotensinogen.
- Key Enzymatic Conversion: Angiotensin I is converted to the octapeptide Angiotensin II by the dipeptidyl carboxypeptidase, angiotensin-converting enzyme (ACE), which removes the C-terminal His-Leu dipeptide. This conversion occurs primarily in the pulmonary circulation.
- Mediation of Effects via Angiotensin II: Angiotensin II is the primary effector molecule. It binds to AT1 receptors, causing:
- Potent vasoconstriction, increasing systemic vascular resistance and blood pressure.
- Stimulation of aldosterone release from the adrenal cortex, promoting renal sodium and water reabsorption.
- Enhancement of sympathetic nervous system activity.
Promotion of vascular and cardiac hypertrophy.
2.PRODUCT INDICATIONS
This product is indicated for extensive research in cardiovascular science, pharmacology, and biochemistry. Key applications include:
- ACE Activity & Inhibition Assays: As the specific, natural substrate for measuring ACE activity in vitro, in cell culture, and in tissue homogenates. It is essential for screening, characterizing, and developing ACE inhibitors (e.g., lisinopril, enalapril), a major class of antihypertensive and cardioprotective drugs.
- Renin-Angiotensin System (RAS) Research: Studying the regulation, tissue-specific expression, and pathophysiology of the entire RAS cascade in models of hypertension, heart failure, and kidney disease.
- Enzyme Kinetics: Used to determine the kinetic parameters (Km, Vmax) of ACE and to study the mechanism of action of various inhibitors.
- Biochemical Standard: Serves as a reference standard in the development of immunoassays (e.g., RIA, ELISA) for quantifying Angiotensin I levels in plasma or tissue samples.
- Drug Discovery: A key reagent in high-throughput screening platforms for novel RAS-modulating therapeutics.
3.CLINICAL EFFICACY OF PRODUCT
Angiotensin I is not administered as a therapeutic. Its profound significance lies in its central role as the target for one of the most important and successful drug classes in cardiovascular medicine.
- Foundation of ACE Inhibitor Therapy: The very definition and measurement of ACE activity rely on its action on Angiotensin I. Therefore, this peptide is the essential substrate that enabled:
- The discovery and development of all ACE inhibitor drugs, which are first-line therapies for hypertension, heart failure, post-myocardial infarction, and diabetic nephropathy.
- The standardization of clinical laboratory tests for plasma ACE activity, used in diagnosing and monitoring conditions like sarcoidosis.
- Cornerstone of Cardiovascular Pathophysiology: Research using Angiotensin I has been fundamental to our understanding of hypertension, heart failure, and renal disease mechanisms, directly guiding therapeutic strategies.
- Diagnostic Utility: Measurement of plasma Angiotensin I concentration, often in conjunction with plasma renin activity, is a key component in the diagnostic workup of endocrine forms of hypertension (e.g., primary aldosteronism, renovascular hypertension).
4.DELIVERY & SHIPPING
We specialize in global logistics for various cosmetic peptides. Your order will be handled with the utmost care, ensuring safe, reliable, and intact delivery.
Professional and Secure Packaging
Each bottle of peptide is protected with a special packaging solution to ensure stability and integrity during transportation.
We can also customize packaging according to customer needs.
Shipping Methods
Main Method: International Air Freight
We primarily use DHL, FedEx, UPS, and TNT because of their global reliability, speed, and advanced tracking systems. Air freight ensures the fastest transit time and minimizes the impact of environmental factors on the product.
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