ANP (1-11), rat
ANP (1-11), rat
TECHNICAL SPECIFICATIONS
| Item | Specification |
|---|---|
| Product Name | ANP (1-11), rat |
| CAS NO. | / |
| Appearance | White to off-white lyophilized powder |
| Molecular Formula | C₄₉H₈₄N₂₀O₁₅S |
| Molecular Weight | 1225.38 g/mol |
| Purity (RP-HPLC) | ≥ 95.0% |
| Solubility | Soluble in water (≥5 mg/mL); also soluble in 5% acetic acid or DMSO |
| Endotoxin | < 1.0 EU/mg |
| Biological Activity | Acts as a vasodilator, modulates fluid/electrolyte balance, inhibits renin-angiotensin-aldosterone system (RAAS), and regulates cardiovascular/renal homeostasis. It is a truncated fragment of full-length ANP, used to study ANP signaling, RAAS interactions, and vasoactive peptide biology |
| Storage Conditions | Store at -20°C (short-term); -80°C (long-term, up to 2 years). Avoid repeated freeze-thaw cycles; store as aliquots in sealed vials, protected from light and moisture. |
| Stock Location | Stock in USA |
| MOQ | 1g |
1.MECHANISM OF ACTION
The mechanism of action for the N-terminal ANP fragment (1-11) is different and less defined than that of the mature ANP, which acts through the NPR-A receptor. Proposed mechanisms for N-terminal fragments like ANP (1-11) include:
- Interaction with Specific Receptors/Clearance Receptors: It may bind to the Natriuretic Peptide Clearance Receptor (NPR-C) with potentially higher affinity than mature ANP. NPR-C is involved in peptide clearance but can also initiate G protein-mediated signaling pathways (e.g., inhibition of adenylate cyclase via Gi), leading to biological effects.
- Modulation of NPR-A Activity: Some N-terminal fragments may modulate the activity or binding of mature ANP to its primary receptor, NPR-A.
- Distinct Biological Effects: Research suggests that N-terminal ANP fragments, including proANP (1-30) and smaller sequences, may have effects on:
- Renal function (modulating sodium and water excretion differently than ANP).
Vascular tone (potentially vasoconstrictive in some contexts, opposing mature ANP).
2.PRODUCT INDICATIONS
This product is indicated for specialized research in cardiovascular and renal endocrinology, focusing on the less-characterized roles of natriuretic peptide precursors. Key applications include:
- Natriuretic Peptide System Research: Studying the biosynthesis, processing, and differential biological activity of ANP and its prohormone fragments in rat models.
- Biomarker Studies: Investigating N-terminal proANP (NT-proANP) as a stable biomarker for cardiac stress and heart failure. ANP (1-11) can serve as a fragment for assay development or as a research analog.
- Functional Characterization: Exploring the potential physiological or pathophysiological roles of N-terminal ANP fragments in blood pressure regulation, renal hemodynamics, and vascular remodeling.
- Receptor Pharmacology: As a ligand in binding studies to characterize interactions with NPR-C and other potential binding sites distinct from NPR-A.
- Comparative Physiology: Comparing the effects of mature ANP versus its N-terminal fragments in isolated tissue or animal experiments.
3.CLINICAL EFFICACY OF PRODUCT
ANP (1-11), rat is a research probe, not a therapeutic. Its "efficacy" lies in its utility for elucidating fundamental biology with potential diagnostic and therapeutic implications.
- Biomarker Validation: Research on N-terminal ANP fragments in animals has been instrumental in validating NT-proANP as a clinically useful, stable biomarker. In human medicine, mid-regional proANP (MR-proANP) is now a well-established blood test for the diagnosis and prognosis of acute heart failure, often outperforming BNP in certain scenarios. Rodent studies using fragments like ANP (1-11) helped establish this concept.
- Uncovering Novel Biology: Studies using this fragment contribute to the understanding that the ANP prohormone encodes multiple bioactive peptides with potentially opposing or modulatory functions, painting a more complex picture of natriuretic peptide physiology.
- Therapeutic Target Potential: Understanding the distinct receptors and signaling pathways activated by N-terminal fragments could reveal new targets for cardiovascular drug development, such as selective NPR-C modulators.
4.DELIVERY & SHIPPING
We specialize in global logistics for various cosmetic peptides. Your order will be handled with the utmost care, ensuring safe, reliable, and intact delivery.
Professional and Secure Packaging
Each bottle of peptide is protected with a special packaging solution to ensure stability and integrity during transportation.
We can also customize packaging according to customer needs.
Shipping Methods
Main Method: International Air Freight
We primarily use DHL, FedEx, UPS, and TNT because of their global reliability, speed, and advanced tracking systems. Air freight ensures the fastest transit time and minimizes the impact of environmental factors on the product.
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