Antibacterial Protein LL-37 (human) CAS NO.154947-66-7
Antibacterial Protein LL-37 (human) CAS NO.154947-66-7
TECHNICAL SPECIFICATIONS
| Item | Specification |
|---|---|
| Product Name | Antibacterial Protein LL-37 |
| CAS NO. | 154947-66-7 |
| Appearance | White to off-white lyophilized powder |
| Molecular Formula | C₂₀₅H₃₄₀N₆₀O₅₃ |
| Molecular Weight | 4493.34g/mol |
| Purity (RP-HPLC) | ≥ 95.0% |
| Solubility | Soluble in water (≥5 mg/mL); also soluble in 5% acetic acid or DMSO |
| Endotoxin | < 1.0 EU/mg |
| Biological Activity | Broad-spectrum antimicrobial peptide ; neutralizes LPS, induces chemotaxis of immune cells , promotes wound healing, and exhibits anti-inflammatory/immunomodulatory effects. |
| Storage Conditions | Store at -20°C (long-term: -80°C for up to 2 years); avoid repeated freeze-thaw cycles; store as aliquots in sealed vials, protected from light and moisture |
| Stock Location | Stock in USA |
| MOQ | 1g |
1.MECHANISM OF ACTION
LL-37 is an amphipathic, α-helical cationic peptide that exerts its effects through multiple mechanisms:
- Membrane Disruption (Primary Antimicrobial Action): Its cationic nature is attracted to the anionic surfaces of microbial membranes. It adopts an amphipathic α-helical structure that integrates into and disrupts the microbial membrane, forming pores or causing general bilayer disintegration, leading to cell lysis and death. This mechanism makes it difficult for microbes to develop resistance.
- Immunomodulation: It acts as a chemoattractant for immune cells (neutrophils, monocytes, T-cells). It can neutralize bacterial endotoxins (LPS), reducing septic shock responses. It also modulates the production of cytokines and chemokines, influencing both pro- and anti-inflammatory pathways.
- Wound Healing & Angiogenesis: It promotes re-epithelialization, angiogenesis (blood vessel formation), and cell proliferation (e.g., in keratinocytes and endothelial cells) by activating growth factor receptors and signaling pathways.
- Biofilm Disruption: It can inhibit the formation and help break down established bacterial biofilms, a major challenge in chronic infections.
2.PRODUCT INDICATIONS
This product is indicated for advanced research in immunology, microbiology, dermatology, and drug discovery. Key applications include:
- Innate Immunity & Host Defense Studies: Researching the role of antimicrobial peptides in the first line of defense against infection.
- Antimicrobial & Antibiofilm Research: As a positive control or lead compound for studying novel antimicrobial strategies, especially against multidrug-resistant pathogens and biofilms.
- Wound Healing & Dermatology: Investigating mechanisms of skin barrier function, psoriasis (where LL-37 is upregulated), atopic dermatitis (often downregulated), and chronic wound models.
- Immunomodulation & Sepsis Research: Studying its role in modulating inflammation, neutralizing LPS, and its potential in sepsis models.
- Drug Discovery: As a template for designing stable, potent, and selective antimicrobial peptide (AMP) analogs with improved therapeutic profiles.
processes in pest insects.
3.CLINICAL EFFICACY OF PRODUCT
LL-37 itself is in various stages of clinical investigation for different indications, demonstrating its significant translational potential.
- Topical Wound Healing: Clinical trials have shown that topical LL-37 (or analogs) can promote healing of venous leg ulcers and diabetic foot ulcers.
- Infectious Disease: It is being explored for topical treatment of infected wounds, burns, and acne vulgaris due to its broad-spectrum activity and antibiofilm effects.
- Autoimmune Disease (Psoriasis): Its role in psoriatic plaques is complex, and modulation of its activity is a therapeutic target.
- Oral Mucositis: Clinical studies are investigating its efficacy in preventing or treating oral mucositis in cancer patients undergoing chemotherapy/radiation.
- Research Validation: Countless preclinical studies validate its efficacy in models of infection, wound healing, and inflammation, solidifying its status as a key endogenous therapeutic peptide.
4.DELIVERY & SHIPPING
We specialize in global logistics for various cosmetic peptides. Your order will be handled with the utmost care, ensuring safe, reliable, and intact delivery.
Professional and Secure Packaging
Each bottle of peptide is protected with a special packaging solution to ensure stability and integrity during transportation.
We can also customize packaging according to customer needs.
Shipping Methods
Main Method: International Air Freight
We primarily use DHL, FedEx, UPS, and TNT because of their global reliability, speed, and advanced tracking systems. Air freight ensures the fastest transit time and minimizes the impact of environmental factors on the product.
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