Apelin-15 (63-77)
TECHNICAL SPECIFICATIONS
| Item | Specification |
|---|---|
| Product Name | Apelin-15 (63-77) |
| CAS NO. | / |
| Appearance | White to off-white lyophilized powder |
| Molecular Formula | C81H135N31O18S |
| Molecular Weight | 1863.24g/mol |
| Purity (RP-HPLC) | ≥ 95.0% |
| Solubility | Soluble in water, phosphate-buffered saline (PBS), or dilute acetic acid (e.g., 0.1% v/v). It is recommended to first dissolve in a small volume of 0.1% acetic acid or sterile water to prepare a 0.1–1.0 mg/mL stock solution. |
| Endotoxin | < 1.0 EU/mg (by LAL test, typical for research-grade peptides) |
| Biological Activity | Apelin-15 (63‑77) is a potent endogenous ligand for the APJ receptor, demonstrating vasodilatory, cardiac inotropic, and metabolic regulatory activities in research assays. |
| Storage Conditions | It is recommended to store the product in a dry environment at -20°C or lower and keep it away from light to ensure long-term stability. |
| Stock Location | Stock in USA |
| MOQ | 1g |
1.MECHANISM OF ACTION
The peptide exerts its effects by binding to and activating the APJ receptor, which couples primarily to the Gi/o protein. This leads to inhibition of adenylate cyclase, a reduction in intracellular cAMP levels, and activation of alternative signaling pathways such as ERK1/2 phosphorylation and Akt activation. This signaling cascade results in vasodilation, positive inotropic effects on the heart, modulation of angiogenesis, and regulation of fluid balance and glucose metabolism.
2.PRODUCT INDICATIONS
Apelin-15 (63-77) is indicated for research applications in cardiovascular physiology, metabolic disorders, and endocrinology. It is used in studies of vasodilation and blood pressure regulation, heart failure models, angiogenesis, fluid and electrolyte homeostasis, and insulin sensitivity. The peptide serves as a key reagent for in vitro receptor binding and functional assays, as well as in vivo investigations into its therapeutic potential for conditions like hypertension, heart failure, and diabetes.
3.CLINICAL EFFICACY OF PRODUCT
While Apelin-15 (63-77) itself is not an approved therapeutic, preclinical and early clinical studies have demonstrated its promising effects, including reducing vascular resistance, improving cardiac output in heart failure models, and enhancing glucose uptake. These findings have established the Apelin/APJ system as a validated therapeutic target, driving the development of stable Apelin analogs and APJ agonists currently in preclinical and early clinical investigation for cardiovascular and metabolic diseases.
4.DELIVERY & SHIPPING
We specialize in global logistics for various cosmetic peptides. Your order will be handled with the utmost care, ensuring safe, reliable, and intact delivery.
Professional and Secure Packaging
Each bottle of peptide is protected with a special packaging solution to ensure stability and integrity during transportation.
We can also customize packaging according to customer needs.
Shipping Methods
Main Method: International Air Freight
We primarily use DHL, FedEx, UPS, and TNT because of their global reliability, speed, and advanced tracking systems. Air freight ensures the fastest transit time and minimizes the impact of environmental factors on the product.
