Name: Aquaporin-2 (255-271) Peptide for Rat Research Use
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Aquaporin-2 (255-271), rat

Aquaporin-2 (255-271), rat is a synthetic, high-purity peptide fragment corresponding to amino acid residues 255-271 of the rat Aquaporin-2 (AQP2) protein. This 17-amino acid sequence is located in the C-terminal cytoplasmic tail of AQP2, the vasopressin-regulated water channel critical for water reabsorption in the renal collecting ducts. This specific fragment is indispensable for antibody generation, epitope mapping, and blocking experiments in renal physiology and nephrology research. It enables precise study of AQP2 trafficking, phosphorylation, and its role in water balance disorders.

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TECHNICAL SPECIFICATIONS

Item	Specification
Product Name	Aquaporin-2 (255-271)
CAS NO.	/
Appearance	White to off-white lyophilized powder
Molecular Formula	C₁₈₃H₂₉₉N₅₅O₅₃
Molecular Weight	4041.60 g/mol
Purity (RP-HPLC)	≥ 95.0%
Solubility	Soluble in water, 5% acetic acid or DMSO
Endotoxin	< 1.0 EU/mg
Biological Activity	Corresponds to the C-terminal cytoplasmic fragment of rat aquaporin-2 water channel; used as antigen for antibody production, AQP2 trafficking studies, and research on renal water reabsorption, diabetes insipidus and nephrogenic disorders.
Storage Conditions	Store at -20°C; long-term at -80°C. Protect from light and moisture. Avoid repeated freeze-thaw cycles.
Stock Location	Stock in USA
MOQ	1g

1.MECHANISM OF ACTION

This peptide itself is not a bioactive ligand but a structural/antigenic probe. Its significance lies in its role within the full-length Aquaporin-2 protein:

Role in Full-Length AQP2: The C-terminal tail of AQP2, containing this sequence, is the primary regulatory domain. Key events in this region include:
- Phosphorylation: Residue Ser-256 (within or near this fragment) is phosphorylated by Protein Kinase A (PKA) in response to vasopressin (AVP) binding to the V2 receptor. This phosphorylation is the master switch triggering the translocation of AQP2-containing vesicles from intracellular stores to the apical plasma membrane, increasing water permeability.
- Protein-Protein Interactions: This domain interacts with other proteins (e.g., scaffolding proteins, motor proteins) to regulate AQP2 trafficking, endocytosis, and recycling.
Research Use of the Peptide: As a free peptide, it is used to:
- Generate specific antibodies for detecting AQP2 (Western blot, immunohistochemistry).
- Act as a blocking/competing peptide to confirm antibody specificity in immunoassays.
- Potentially inhibit specific protein-protein interactions in vitro to study their functional importance.

2.PRODUCT INDICATIONS

This product is indicated for specialized research in renal physiology, nephrology, and cell biology. Key applications include:

Antibody Production & Validation: As an immunogen to raise polyclonal or monoclonal antibodies specific to the C-terminal tail of rat AQP2. It is also used as a blocking peptide to confirm that antibody staining is specific to the AQP2(255-271) epitope.
Renal Physiology & AQP2 Trafficking Studies: Investigating the molecular mechanisms of vasopressin action, AQP2 phosphorylation, and membrane trafficking in rat kidney tissue or cell models (e.g., mpkCCD cells).
Disease Model Research: Studying AQP2 dysregulation in rat models of water balance disorders, such as:
- Nephrogenic Diabetes Insipidus (NDI): Where AQP2 trafficking is impaired.
- Syndrome of Inappropriate Antidiuretic Hormone (SIADH): Where AQP2 is inappropriately membrane-localized.
- Congestive Heart Failure/Liver Cirrhosis: Conditions involving water retention and altered AQP2 expression.
Protein Interaction Studies: Potentially used in pull-down or co-immunoprecipitation experiments to identify or confirm binding partners of the AQP2 C-terminus.

3.CLINICAL EFFICACY OF PRODUCT

Aquaporin-2 (255-271), rat is a research reagent, not a therapeutic. Its "efficacy" is defined by its critical role in enabling fundamental and translational research that has direct clinical implications.

Enabling Discovery Research: Antibodies generated using this peptide have been indispensable for thousands of studies mapping the distribution, regulation, and pathophysiology of AQP2. This research has defined our modern understanding of water balance at the molecular level.
Diagnostic Tool Development: Understanding AQP2 regulation, made possible by tools like this peptide, led to the measurement of urinary AQP2 as a biomarker for renal concentration ability and the action of vasopressin in clinical studies of water balance disorders.
Therapeutic Target Validation: Research using reagents specific to the AQP2 C-terminus has identified the V2 receptor-AQP2 phosphorylation cascade as the key drug target for treating hyponatremia. This directly informed the development of vaptans (V2 receptor antagonists like tolvaptan), which are now approved therapies for SIADH and other hyponatremic conditions. The peptide helps study why AQP2 sometimes doesn't respond to vaptans .

GlobalTech Co., Ltd. is committed to providing high-purity biotechnological peptide products, adhering strictly to quality standards and obtaining internationally recognized certifications.

Our production partners all employ GMP-compliant production systems and possess standardized quality control processes covering raw material procurement, synthesis, purification, testing, packaging, and storage. Each batch of product comes with complete documentation, including a Certificate of Analysis (COA), HPLC purity report, mass spectrometry (MS) chromatograms, and third-party testing reports available upon request.

We prioritize:
1.A rigorous quality management system
2.Batch traceability and stability data
3.Professional laboratory testing and validation
4.Compliance with international trade standards

Our commitment to quality, transparency, and regulatory compliance ensures the provision of reliable, stable, and research-grade peptide products to our global partners.

4.DELIVERY & SHIPPING

We specialize in global logistics for various cosmetic peptides. Your order will be handled with the utmost care, ensuring safe, reliable, and intact delivery.
Professional and Secure Packaging
Each bottle of peptide is protected with a special packaging solution to ensure stability and integrity during transportation.
We can also customize packaging according to customer needs.
Shipping Methods
Main Method: International Air Freight

We primarily use DHL, FedEx, UPS, and TNT because of their global reliability, speed, and advanced tracking systems. Air freight ensures the fastest transit time and minimizes the impact of environmental factors on the product.

Global Technology Co., Ltd. is a modern and advanced enterprise specializing in the production and export of active pharmaceutical ingredients (APIs), peptides, and plant extracts. The company invests in and collaborates closely with domestic manufacturers holding GMP, DMF, and FDA certifications, as well as laboratories at renowned universities, to meet diverse customer needs ranging from gram-level to ton-level. This enables Dejurui Pharmaceutical to provide customers with more flexible and convenient access to cost-effective, high-quality products and superior services.

We focus on the research and development and supply of high-quality chemical products, strictly adhering to international standards and quality systems. Our products are stable in performance and reliable in purity, widely used in industrial manufacturing, scientific research, and the fine chemical industry. We provide solid support at every stage with a professional and responsible attitude.

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