ARA290 (Cibinetide) CAS NO.1208243-50-8
ARA290 (Cibinetide) CAS NO.1208243-50-8
TECHNICAL SPECIFICATIONS
| Item | Specification |
|---|---|
| Product Name | ARA290 (Cibinetide) |
| CAS NO. | 1208243 – 50 – 8 |
| Appearance | White to off-white lyophilized powder |
| Molecular Formula | C51H84N16O21 |
| Molecular Weight | 1257.31 g/mol |
| Purity (RP-HPLC) | ≥ 98.0% |
| Solubility | Soluble in water |
| Endotoxin | < 1.0 EU/mg |
| Biological Activity | ARA290 exhibits cytoprotective, anti – inflammatory, and tissue – regenerative properties. In pre – clinical and some clinical studies, it has demonstrated potential in treating various diseases and conditions related to tissue damage, inflammation, and oxidative stress |
| Storage Conditions | Store at – 20°C in a dry and dark environment. Avoid repeated freeze – thaw cycles to maintain product stability. |
| Stock Location | Stock in USA |
| MOQ | 1g |
1.MECHANISM OF ACTION
ARA290 functions by binding to the erythropoietin receptor (EPOR) and its associated signaling complexes. This binding activates downstream signaling pathways, including the JAK2 – STAT5 pathway. These pathways play crucial roles in cell survival, proliferation, and differentiation. By modulating these signaling cascades, ARA290 exerts its cytoprotective, anti – inflammatory, and tissue – regenerative effects. It can protect cells from various forms of stress, such as oxidative stress and ischemia – reperfusion injury, and also reduce the production of pro – inflammatory cytokines.
2.PRODUCT INDICATIONS
Renal Diseases: Investigated for reducing inflammation and promoting tissue repair in acute/chronic kidney injury.
Cardiovascular Disorders: Potential use in myocardial infarction and heart failure to protect cardiac cells, improve contractility, and reduce post-infarction scar formation.
Neurological Conditions: Explored for aiding neural tissue recovery and mitigating neuroinflammation in disorders like stroke or traumatic brain injury.
Metabolic Diseases: Studied for alleviating oxidative stress and tissue damage in metabolic syndrome-related complications.
3.CLINICAL EFFICACY OF PRODUCT
In renal injury models: Reduced kidney damage progression, improved glomerular filtration rate (GFR), and decreased inflammatory cell infiltration.
In cardiovascular models: Enhanced cardiac function and reduced infarct size after myocardial infarction.
In neurological models: Promoted neuronal survival and reduced neuroinflammatory markers
4.DELIVERY & SHIPPING
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Professional and Secure Packaging
Each bottle of peptide is protected with a special packaging solution to ensure stability and integrity during transportation.
We can also customize packaging according to customer needs.
Shipping Methods
Main Method: International Air Freight
We primarily use DHL, FedEx, UPS, and TNT because of their global reliability, speed, and advanced tracking systems. Air freight ensures the fastest transit time and minimizes the impact of environmental factors on the product.
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