Name: Arg8-Vasopressin CAS 113-79-1: Pure Peptide for Research Use
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[Arg8]-Vasopressin CAS NO.113-79-1

[Arg⁸]-Vasopressin is a synthetic, nonapeptide analog of the endogenous pituitary hormone arginine vasopressin (AVP). This research-grade peptide features an arginine residue at position 8, which is the defining characteristic of the antidiuretic hormone found in most mammals, including humans. It is a potent agonist for vasopressin receptors (V1a, V1b, and V2), making it a crucial tool for studying fluid balance, cardiovascular function, and neuroendocrine regulation.

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TECHNICAL SPECIFICATIONS

Item	Specification
Product Name	[Arg8]-Vasopressin
CAS NO.	113-79-1
Appearance	White to off-white lyophilized powder
Molecular Formula	C46H67N15O12S2
Molecular Weight	1086.25/mol
Purity (RP-HPLC)	≥98%
Solubility	Soluble in water (≥50 mg/mL), dilute acetic acid, or DMSO
Endotoxin	≤1.0 EU/mg
Biological Activity	Potent vasopressor and antidiuretic activity; binds to V1a, V1b, and V2 receptors
Storage Conditions	Store at -20°C to -80°C in a dry, dark environment; avoid repeated freeze-thaw cycles
Stock Location	Stock in USA
MOQ	1g

1.MECHANISM OF ACTION

This peptide exerts its effects by binding to and activating specific G protein-coupled vasopressin receptors. Its primary physiological action is mediated through V2 receptors in the renal collecting ducts, where it triggers a Gs protein-mediated signaling cascade. This leads to the insertion of aquaporin-2 (AQP2) water channels into the apical membrane, increasing water reabsorption and concentrating urine (antidiuretic effect). Additionally, via V1a receptors on vascular smooth muscle, it causes vasoconstriction, increasing peripheral vascular resistance and blood pressure.

2.PRODUCT INDICATIONS

This product is indicated for in vitro and in vivo research in nephrology, endocrinology, and cardiovascular physiology. Key applications include: studying the molecular mechanisms of water reabsorption and renal concentrating ability, investigating V1a receptor-mediated vasoconstriction and its role in blood pressure regulation, exploring central effects on stress, social behavior, and memory via V1b receptors, and serving as the reference standard full agonist in functional assays (e.g., cAMP accumulation for V2, calcium mobilization for V1) and receptor binding studies.

3.CLINICAL EFFICACY OF PRODUCT

[Arg⁸]-Vasopressin (AVP) itself is used clinically under specific conditions. Its efficacy is well-established: it is a lifesaving treatment for diabetes insipidus (central type) to correct water loss, and it is used as a potent vasopressor in advanced cardiac life support (ACLS) for vasodilatory shock (e.g., septic shock) to increase mean arterial pressure. Research using this peptide continues to refine its therapeutic applications and supports the development of novel, selective vasopressin receptor agonists and antagonists for conditions like heart failure, hyponatremia, and social disorders.

4.DELIVERY & SHIPPING

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Shipping Methods
Main Method: International Air Freight

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