Name: Human Tyrosinase(369-377) CAS 168650-46-2 for Research
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[Asp371] Tyrosinase(369-377), human CAS NO.168650-46-2

[Asp371] Tyrosinase(369-377), human is a synthetic peptide fragment corresponding to residues 369-377 of the human tyrosinase enzyme, with an aspartic acid substitution at position 371. This sequence represents a key immunodominant epitope recognized by T-cells, making it a crucial research tool for investigating immune responses in melanoma, autoimmune vitiligo, and immunotherapy development.

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TECHNICAL SPECIFICATIONS

Item	Specification
Product Name	[Asp371] Tyrosinase(369-377), human
CAS NO.	168650-46-2
Appearance	White to off-white lyophilized powder
Molecular Formula	C42H66N10O16S2
Molecular Weight	1031.2 g/mol
Purity (RP-HPLC)	≥ 95.0%
Solubility	Soluble in water, phosphate‑buffered saline (PBS), or dilute aqueous solutions. Recommended to dissolve in sterile water to prepare a 0.1–1.0 mg/mL stock solution.
Endotoxin	< 1.0 EU/mg
Biological Activity	This peptide is a modified epitope derived from human tyrosinase, often used in immunological research (e.g., T‑cell activation studies, epitope mapping, vaccine development) related to melanoma and autoimmune vitiligo. The Asp³⁷¹ substitution may alter MHC‑binding affinity and T‑cell recognition.
Storage Conditions	Lyophilized powder: Store desiccated at –20 °C or below, protected from light, for long‑term stability. Reconstituted solution: Aliquot and store at ≤ –20 °C; avoid repeated freeze‑thaw cycles.
Stock Location	Stock in USA
MOQ	1g

1.MECHANISM OF ACTION

The peptide functions as a T-cell epitope. When processed and presented on MHC class I or II molecules by antigen-presenting cells, it binds to specific T-cell receptors (TCRs) on CD8+ cytotoxic T-cells or CD4+ helper T-cells, triggering T-cell activation, proliferation, and effector functions such as cytokine release and cytotoxic activity, thereby initiating an antigen-specific immune response against cells expressing the tyrosinase antigen.

2.PRODUCT INDICATIONS

This peptide is indicated for research applications in immunology and oncology, including T-cell activation and proliferation assays, epitope mapping, melanoma vaccine research, and studies of autoimmune vitiligo pathogenesis. It is also used in the development and validation of immunotherapies, such as adoptive T-cell transfer and cancer vaccines targeting the tyrosinase antigen.

3.CLINICAL EFFICACY OF PRODUCT

As a research-grade reagent, [Asp371] Tyrosinase(369-377) is not a clinically approved therapeutic. However, peptides derived from this epitope are under investigation in clinical trials for melanoma immunotherapy. Early-phase trials have shown that tyrosinase-targeted vaccines can induce specific T-cell responses and, in some cases, objective clinical responses, supporting the potential of this epitope in cancer immunotherapy, though broader efficacy and approval are pending further clinical validation.

4.DELIVERY & SHIPPING

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Professional and Secure Packaging
Each bottle of peptide is protected with a special packaging solution to ensure stability and integrity during transportation.
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Main Method: International Air Freight

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