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Atrial Natriuretic Peptide Substrate, [pS6] ANF 1-28
TECHNICAL SPECIFICATIONS
| Item | Specification |
|---|---|
| Product Name | Atrial Natriuretic Peptide Substrate, [pS6] ANF 1‑28 |
| CAS NO. | |
| Appearance | White to off-white lyophilized powder |
| Molecular Formula | C128H206N45PO42S2 |
| Amino Acid Sequence | H‑Ser‑Leu‑Arg‑Arg‑Ser‑Ser‑Cys‑Phe‑Gly‑Gly‑Arg‑Ile‑Asp‑Arg‑Ile‑Gly‑Ala‑Gln‑Ser‑Gly‑Leu‑Gly‑Cys‑Asn‑Ser‑Phe‑Arg‑Tyr‑OH (human ANF 1‑28 with phosphorylated Ser at position 6) |
| Molecular Weight | 3143.5g/mol |
| Purity (RP-HPLC) | ≥95.0% (customizable to ≥98.0%) |
| Solubility | Soluble in water, dilute acetic acid, or phosphate‑buffered saline (PBS) |
| Endotoxin | < 1.0 EU/mg |
| Biological Activity | Phosphorylated ANF derivative; used as a substrate for kinases (e.g., PKG, PKA) or phosphatase studies, and in cardiovascular signal‑transduction research. |
| Storage Conditions | Store at –20 °C, protected from light and moisture. For long‑term storage, recommend –80 °C. |
| Stock Location | Stock in USA |
| MOQ | 1mg |
1.MECHANISM OF ACTION
This peptide functions as a phosphorylated substrate that binds to natriuretic peptide receptors (e.g., NPR-A/NPR-B) and interacts with key kinases (such as PKG and PKA) or phosphatases. It enables researchers to investigate phosphorylation-dependent signaling events involved in fluid balance, blood pressure regulation, and cardiovascular function.
2.PRODUCT INDICATIONS
Atrial Natriuretic Peptide Substrate, [pS6] ANF 1-28 is widely used in cardiovascular research, kinase/phosphatase activity assays, and studies of natriuretic peptide system dynamics. It is also employed in drug discovery and preclinical investigations targeting heart failure, hypertension, and renal disorders.
3.CLINICAL EFFICACY OF PRODUCT
While this product is intended for research use only, it provides valuable insights into disease mechanisms and helps identify potential therapeutic targets in cardiovascular and renal pathologies. Its application in preclinical models contributes to the development of novel treatments for conditions related to natriuretic peptide dysfunction.
4.DELIVERY & SHIPPING
We specialize in global logistics for various cosmetic peptides. Your order will be handled with the utmost care, ensuring safe, reliable, and intact delivery.
Professional and Secure Packaging
Each bottle of peptide is protected with a special packaging solution to ensure stability and integrity during transportation.
We can also customize packaging according to customer needs.
Shipping Methods
Main Method: International Air Freight
We primarily use DHL, FedEx, UPS, and TNT because of their global reliability, speed, and advanced tracking systems. Air freight ensures the fastest transit time and minimizes the impact of environmental factors on the product.
