Name: Avenanthramide A - Pure Anti-Inflammatory Compound 108605-70-5
Availability: InStock
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Avenanthramide A CAS NO.108605-70-5

Avenanthramide A is a high-purity natural phenolic alkaloid, specifically categorized as a phytoalexin uniquely derived from oats (Avena sativa), supplied as a premium research-grade reagent for scientists delving into plant-derived bioactive compounds and functional food science. It is distinguished by its structural fusion of anthranilic acid and hydroxycinnamic acid moieties, making it an essential reference standard for researchers in nutraceutical development, dermatological cosmetics, and natural product pharmacology. This compound is particularly valued for its inherent stability and multi-target bioactivity, serving as a critical benchmark for laboratories investigating the health-promoting properties of whole grains, the mechanistic actions of oat polyphenols, and the development of novel antioxidant or anti-inflammatory formulations in both academic and industrial R&D settings.

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TECHNICAL SPECIFICATIONS

Item	Specification
Product Name	Avenanthramide A
CAS NO.108605-70-5	108605-70-5
Appearance	Pale yellow to off-white powder or crystalline solid
Molecular Formula	C16H13NO5
Molecular Weight	299.28 g/mol
Purity (RP-HPLC)	≥98%
Solubility	Soluble in methanol, ethanol, DMSO, and acetone; slightly soluble in water
Endotoxin	≤1 EU/mg
Biological Activity	Potent antioxidant and anti-inflammatory activity; inhibits NF-κB and MAPK signaling pathways; protects skin barrier function
Storage Conditions	Store at -20°C in a dry, dark place; avoid light and moisture exposure
Stock Location	USA
MOQ	1g

1.MECHANISM OF ACTION

The primary biological action of Avenanthramide A involves the direct binding to and inhibition of the RNA helicase DDX3, a key oncogenic protein, which subsequently disrupts mitochondrial bioenergetics leading to increased reactive oxygen species (ROS) production and mitochondrial swelling. Concurrently, it exerts potent anti-inflammatory effects by suppressing the NF-κB signaling pathway, thereby inhibiting the transcription of pro-inflammatory cytokines and reducing oxidative stress at the cellular level. This dual capability to trigger ROS-mediated apoptosis in specific pathological cells while simultaneously protecting normal cellular environments from inflammatory damage underscores its unique pharmacological profile, making it a focal point for studies on redox biology, serine metabolism remodeling, and signal transduction modulation.

2.PRODUCT INDICATIONS

This product is strictly indicated for in vitro research, analytical chemistry, and controlled laboratory use, targeting a specialized audience that includes pharmacologists, food scientists, cosmetic chemists, and oncology researchers rather than clinical or therapeutic application. It is ideally suited for professionals developing HPLC or LC-MS methods to quantify oat-derived polyphenols in functional foods, as well as for toxicologists and cell biologists modeling the effects of dietary antioxidants on chronic diseases such as colorectal cancer, cardiovascular dysfunction, and skin irritation. Furthermore, it serves as a vital benchmark compound for formulation scientists working on soothing skincare ingredients or anti-aging cosmeceuticals who require verified natural actives to validate product claims regarding anti-itch, anti-redness, and anti-irritant efficacy.

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3.CLINICAL EFFICACY OF PRODUCT

As a non-therapeutic chemical standard, Avenanthramide A does not possess clinical efficacy in treating patients, yet its research utility is highly validated in preclinical models where it effectively demonstrates potent anti-tumor efficacy, particularly in colorectal cancer studies by inducing cancer cell apoptosis through DDX3 inhibition and SHMT2 downregulation. In various controlled experimental settings, it has proven instrumental in confirming the bioavailability and bioactivity of oat avenanthramides, successfully replicating anti-inflammatory and antioxidant responses that correlate with dietary oat consumption benefits observed in epidemiological data. Its reliability in these research contexts allows scientists to accurately gauge the potential of natural phytoalexins in mitigating endothelial dysfunction and inflammatory pathways, thereby providing robust foundational data for future nutraceutical and pharmaceutical development.

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4.Certificate

GlobalTech Co., Ltd. is committed to providing high-purity biotechnological peptide products, adhering strictly to quality standards and obtaining internationally recognized certifications.

Our production partners all employ GMP-compliant production systems and possess standardized quality control processes covering raw material procurement, synthesis, purification, testing, packaging, and storage. Each batch of product comes with complete documentation, including a Certificate of Analysis (COA), HPLC purity report, mass spectrometry (MS) chromatograms, and third-party testing reports available upon request.

We prioritize:

1.A rigorous quality management system

2.Batch traceability and stability data

3.Professional laboratory testing and validation

4.Compliance with international trade standards

Our commitment to quality, transparency, and regulatory compliance ensures the provision of reliable, stable, and research-grade peptide products to our global partners.

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5.DELIVERY & SHIPPING

We specialize in global logistics for various cosmetic peptides. Your order will be handled with the utmost care, ensuring safe, reliable, and intact delivery.

Professional and Secure Packaging

Each bottle of peptide is protected with a special packaging solution to ensure stability and integrity during transportation.

We can also customize packaging according to customer needs.

Shipping Methods

Main Method: International Air Freight

We primarily use DHL, FedEx, UPS, and TNT because of their global reliability, speed, and advanced tracking systems. Air freight ensures the fastest transit time and minimizes the impact of environmental factors on the product.

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Global Technology Co., Ltd. is a modern and advanced enterprise specializing in the production and export of active pharmaceutical ingredients (APIs), peptides, and plant extracts. The company invests in and collaborates closely with domestic manufacturers holding GMP, DMF, and FDA certifications, as well as laboratories at renowned universities, to meet diverse customer needs ranging from gram-level to ton-level. This enables Dejurui Pharmaceutical to provide customers with more flexible and convenient access to cost-effective, high-quality products and superior services.

We focus on the research and development and supply of high-quality chemical products, strictly adhering to international standards and quality systems. Our products are stable in performance and reliable in purity, widely used in industrial manufacturing, scientific research, and the fine chemical industry. We provide solid support at every stage with a professional and responsible attitude.

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