Name: Big Gastrin-1 Human Neuroptide for Gastric Acid Research
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Big Gastrin – 1, human CAS NO.60675-77-6

Big Gastrin-1, human (CAS NO. 60675-77-6) is a high-molecular-weight neuropeptide with the molecular formula C₁₇₆H₂₅₁N₄₃O₅₃S and molecular weight 3849.3 g/mol. As a key regulator of gastric function in humans, it is widely used to study gastric acid secretion, gastrin receptor pharmacology, and preclinical drug development for acid-related disorders.

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TECHNICAL SPECIFICATIONS

Item	Specification
Product Name	Big Gastrin-1, human
CAS NO.	60675-77-6
Appearance	White to off-white lyophilized powder
Molecular Formula	C₁₇₆H₂₅₁N₄₃O₅₃S
Molecular Weight	3849.3 g/mol
Purity (RP-HPLC)	≥ 98.0%
Solubility	Freely soluble in deionized water (pH 4.0–7.0) or 0.1 M acetic acid; partially soluble in DMSO (≤2 mg/mL) to avoid precipitation.
Endotoxin	< 1.0 EU/mg
Biological Activity	Potent agonist of the cholecystokinin-2 (CCK₂) receptor (human, Ki: 0.05–0.5 nM), stimulating gastric acid secretion, gastrin release, and proliferation of gastric mucosal cells. Validated for use in human-relevant pharmacological and physiological studies.
Storage Conditions	Lyophilized powder: Store at -20°C in a tightly sealed, light-protected container; avoid moisture and repeated freeze-thaw cycles. After reconstitution, aliquot into single-use vials and store at -80°C (stable for 6 months) or 2–8°C (stable for 1 week).
Stock Location	Stock in USA
MOQ	1g

1.MECHANISM OF ACTION

CCK₂ Receptor Activation: Binds to the cholecystokinin-2 (CCK₂) receptor (human-specific, Ki: 0.05–0.5 nM), triggering Gq/11 protein-coupled signaling cascades.

Gastric Acid Secretion: Stimulates enterochromaffin-like (ECL) cells in the stomach to release histamine, which induces gastrin secretion from G cells, ultimately increasing gastric acid production.

Mucosal Growth: Promotes proliferation of gastric mucosal cells via CCK₂ receptor-mediated MAPK/ERK pathway activation, supporting tissue repair and regeneration.

2.PRODUCT INDICATIONS

Gastrointestinal Research: Studying gastric acid regulation, peptic ulcer disease, and gastroesophageal reflux disorder (GERD) in human-relevant models.

Pharmacology Studies: Evaluating CCK₂ receptor antagonists (e.g., proton pump inhibitors, H₂ blockers) and agonists for acid suppression or mucosal protection.

Preclinical Drug Development: Testing the efficacy and safety of anti-ulcer drugs, gastric stimulants, or CCK₂-targeted therapies in human-derived cell lines or organoids.

3.CLINICAL EFFICACY OF PRODUCT

Increases gastric acid output by 60–80% in human gastric gland cultures (ED₅₀: 0.2 nM).

Therapeutic Relevance: CCK₂ receptor antagonists derived from Big Gastrin-1, human are in clinical trials for acid-related disorders, with this peptide serving as a key reference standard.

4.DELIVERY & SHIPPING

We specialize in global logistics for various cosmetic peptides. Your order will be handled with the utmost care, ensuring safe, reliable, and intact delivery.
Professional and Secure Packaging
Each bottle of peptide is protected with a special packaging solution to ensure stability and integrity during transportation.
We can also customize packaging according to customer needs.
Shipping Methods
Main Method: International Air Freight

We primarily use DHL, FedEx, UPS, and TNT because of their global reliability, speed, and advanced tracking systems. Air freight ensures the fastest transit time and minimizes the impact of environmental factors on the product.