![Biotin-[Glu1]-Gastrin I (human) (phosphorylated)](https://images.cnmqh.com/images/a10134/45254_74_2-20260126070310.webp "Biotin-[Glu1]-Gastrin I (human) (phosphorylated)")
![Biotin-[Glu1]-Gastrin I (human) (phosphorylated)](https://images.cnmqh.com/images/a10134/ims-2026-01-26T105553.890-20260126030001.webp "Biotin-[Glu1]-Gastrin I (human) (phosphorylated)")
Biotin-[Glu1]-Gastrin I (human) (phosphorylated)
Biotin-[Glu1]-Gastrin I (human) (phosphorylated)
TECHNICAL SPECIFICATIONS
| Item | Specification |
|---|---|
| Product Name | Biotin-[Glu1]-Gastrin I (human) (phosphorylated) |
| CAS NO. | \ |
| Appearance | White to off-white lyophilized powder |
| Molecular Formula | C₁₀₇H₁₄₁N₂₂O₃₇PS₂ |
| Molecular Weight | 2422.53 g/mol |
| Purity (RP-HPLC) | ≥ 98.0% |
| Solubility | Freely soluble in deionized water (pH 4.0–7.0) or 0.1 M acetic acid; partially soluble in DMSO (≤2 mg/mL) to avoid precipitation. |
| Endotoxin | < 1.0 EU/mg |
| Biological Activity | Phosphorylated, biotin-labeled analog of human Gastrin I, retaining CCK₂ receptor binding affinity (human CCK₂ receptor Ki: 0.1–1 nM). Phosphorylation at specific residues (e.g., Ser⁴) modulates stability and receptor interaction. Biotin enables detection via streptavidin conjugates . |
| Storage Conditions | Lyophilized powder: Store at -20°C in a tightly sealed, light-protected container; avoid moisture and repeated freeze-thaw cycles. |
| Stock Location | Stock in USA |
| MOQ | 1g |
1.MECHANISM OF ACTION
CCK₂ Receptor Activation: Retains high affinity for the cholecystokinin-2 (CCK₂) receptor (human, Ki: 0.1–1 nM), binding to the same site as native gastrin to stimulate gastric acid secretion and mucosal growth via Gq/11-coupled signaling.
Phosphorylation-Mediated Stability: Site-specific phosphorylation (e.g., at serine residues) enhances resistance to proteolytic degradation, prolonging half-life in biological samples.
Biotin-Driven Detection: The N-terminal biotin label binds streptavidin-conjugated probes (e.g., HRP, fluorophores) with ultra-high affinity (Kd ~10⁻¹⁵ M), enabling sensitive detection in ELISA, Western blot, and immunohistochemistry.
2.PRODUCT INDICATIONS
Gastrin Metabolism Research: Studying phosphorylation-dependent regulation of gastrin stability, processing, and receptor interaction in human gastric tissues.
CCK₂ Receptor Pharmacology: Evaluating receptor agonists/antagonists using biotin-labeled gastrin to track binding kinetics and downstream signaling.
Diagnostic Tool Development: Designing phospho-gastrin-specific assays for clinical samples (e.g., serum, gastric juice) to detect hypergastrinemia or gastrinoma.
3.CLINICAL EFFICACY OF PRODUCT
Preclinical Validation:
Binds human CCK₂ receptors with 80–90% of native gastrin’s affinity (radioligand binding assays).
Resists degradation in human serum for 24+ hours (vs. 2–4 hours for unmodified gastrin).
Enables detection of phospho-gastrin in gastric cancer cell lysates at picogram levels (ELISA, LOD: 10 pg/mL).
Therapeutic Relevance: Supports development of phospho-gastrin biomarkers for early diagnosis of Zollinger-Ellison syndrome and monitoring anti-ulcer therapy efficacy.
4.DELIVERY & SHIPPING
We specialize in global logistics for various cosmetic peptides. Your order will be handled with the utmost care, ensuring safe, reliable, and intact delivery.
Professional and Secure Packaging
Each bottle of peptide is protected with a special packaging solution to ensure stability and integrity during transportation.
We can also customize packaging according to customer needs.
Shipping Methods
Main Method: International Air Freight
We primarily use DHL, FedEx, UPS, and TNT because of their global reliability, speed, and advanced tracking systems. Air freight ensures the fastest transit time and minimizes the impact of environmental factors on the product.
May 25, 26
Premium API Oxandrolone Ucinky Manufacturing
Premium API Oxandrolone Ucinky Manufacturing Leading global supplier of high-purity chemical raw materials for pharmaceutical grade Oxandrolone Ucinky, combining precision engineering with industrial scale. 5000 kg Annual Output 120 Countries Served 5 Days Sample Lead Time 99.7 On-Time Delivery Industrial Precision Pure Chemical Synthesis Engineering the future of pharmaceutical intermediates with unmatched stability. Our facility stands as a global leader in the oxandrolone ucinky sector, utilizing CRYOGENIC CRYSTALLIZATION and advanced chromatography to ensure an assay purity exceeding 99.8. We integrate a fully automated closed-loop system that eliminates human error and contamination.
May 22, 26
Clinical Benefits and Applications of Oxandrolone Therapy
Oxandrolone therapy represents a sophisticated intersection of endocrine science and regenerative medicine, primarily utilized to address muscle wasting and metabolic dysfunction. In the global pharmaceutical landscape, this specific approach to androgen therapy is valued for its unique ability to promote protein synthesis while exhibiting a lower androgenic profile compared to traditional steroids, making it a critical tool for patients recovering from severe trauma or chronic illness. From a clinical perspective, understanding the nuances of oxandrolone therapy is essential for optimizing patient outcomes in weight gain and tissue repair.
May 20, 26
Clinical Benefits and Production of Oxandrolone Steroid
The global pharmaceutical landscape has seen a significant rise in the demand for highly specialized anabolic agents, among which the oxandrolone steroid stands out due to its unique chemical profile and therapeutic versatility. As a modified version of dihydrotestosterone, this compound provides a potent means of addressing muscle wasting and metabolic deficits, making it a critical asset in both clinical rehabilitation and advanced physiological research. Understanding the nuances of this synthetic compound is essential for healthcare providers and researchers alike, as it balances efficacy with a relatively lower androgenic profile compared to other steroids.
