![Biotin-[Glu1]-Gastrin I (human) (phosphorylated)](https://images.cnmqh.com/images/a10134/45254_74_2-20260126070310.webp "Biotin-[Glu1]-Gastrin I (human) (phosphorylated)")
![Biotin-[Glu1]-Gastrin I (human) (phosphorylated)](https://images.cnmqh.com/images/a10134/ims-2026-01-26T105553.890-20260126030001.webp "Biotin-[Glu1]-Gastrin I (human) (phosphorylated)")
Biotin-[Glu1]-Gastrin I (human) (phosphorylated)
Biotin-[Glu1]-Gastrin I (human) (phosphorylated)
TECHNICAL SPECIFICATIONS
| Item | Specification |
|---|---|
| Product Name | Biotin-[Glu1]-Gastrin I (human) (phosphorylated) |
| CAS NO. | \ |
| Appearance | White to off-white lyophilized powder |
| Molecular Formula | C₁₀₇H₁₄₁N₂₂O₃₇PS₂ |
| Molecular Weight | 2422.53 g/mol |
| Purity (RP-HPLC) | ≥ 98.0% |
| Solubility | Freely soluble in deionized water (pH 4.0–7.0) or 0.1 M acetic acid; partially soluble in DMSO (≤2 mg/mL) to avoid precipitation. |
| Endotoxin | < 1.0 EU/mg |
| Biological Activity | Phosphorylated, biotin-labeled analog of human Gastrin I, retaining CCK₂ receptor binding affinity (human CCK₂ receptor Ki: 0.1–1 nM). Phosphorylation at specific residues (e.g., Ser⁴) modulates stability and receptor interaction. Biotin enables detection via streptavidin conjugates . |
| Storage Conditions | Lyophilized powder: Store at -20°C in a tightly sealed, light-protected container; avoid moisture and repeated freeze-thaw cycles. |
| Stock Location | Stock in USA |
| MOQ | 1g |
1.MECHANISM OF ACTION
CCK₂ Receptor Activation: Retains high affinity for the cholecystokinin-2 (CCK₂) receptor (human, Ki: 0.1–1 nM), binding to the same site as native gastrin to stimulate gastric acid secretion and mucosal growth via Gq/11-coupled signaling.
Phosphorylation-Mediated Stability: Site-specific phosphorylation (e.g., at serine residues) enhances resistance to proteolytic degradation, prolonging half-life in biological samples.
Biotin-Driven Detection: The N-terminal biotin label binds streptavidin-conjugated probes (e.g., HRP, fluorophores) with ultra-high affinity (Kd ~10⁻¹⁵ M), enabling sensitive detection in ELISA, Western blot, and immunohistochemistry.
2.PRODUCT INDICATIONS
Gastrin Metabolism Research: Studying phosphorylation-dependent regulation of gastrin stability, processing, and receptor interaction in human gastric tissues.
CCK₂ Receptor Pharmacology: Evaluating receptor agonists/antagonists using biotin-labeled gastrin to track binding kinetics and downstream signaling.
Diagnostic Tool Development: Designing phospho-gastrin-specific assays for clinical samples (e.g., serum, gastric juice) to detect hypergastrinemia or gastrinoma.
3.CLINICAL EFFICACY OF PRODUCT
Preclinical Validation:
Binds human CCK₂ receptors with 80–90% of native gastrin’s affinity (radioligand binding assays).
Resists degradation in human serum for 24+ hours (vs. 2–4 hours for unmodified gastrin).
Enables detection of phospho-gastrin in gastric cancer cell lysates at picogram levels (ELISA, LOD: 10 pg/mL).
Therapeutic Relevance: Supports development of phospho-gastrin biomarkers for early diagnosis of Zollinger-Ellison syndrome and monitoring anti-ulcer therapy efficacy.
4.DELIVERY & SHIPPING
We specialize in global logistics for various cosmetic peptides. Your order will be handled with the utmost care, ensuring safe, reliable, and intact delivery.
Professional and Secure Packaging
Each bottle of peptide is protected with a special packaging solution to ensure stability and integrity during transportation.
We can also customize packaging according to customer needs.
Shipping Methods
Main Method: International Air Freight
We primarily use DHL, FedEx, UPS, and TNT because of their global reliability, speed, and advanced tracking systems. Air freight ensures the fastest transit time and minimizes the impact of environmental factors on the product.
Nov 05, 26
Global Market Analysis and Oxandrolone 50mg Price Guide
For B2B pharmaceutical buyers and researchers, understanding the oxandrolone 50mg price involves analyzing more than just a numerical value; it requires a comprehensive look at API purity, synthesis methods, and global supply chain stability. As a specialized anabolic steroid derivative, the cost is heavily influenced by the quality of raw materials and the rigor of the laboratory testing involved in the production process. This article explores the economic and technical variables that dictate market pricing for this specific compound. In the context of the global API market, pricing volatility is often tied to regulatory shifts in key manufacturing hubs
Nov 04, 26
How to Select High Purity Alisol C CAS 30489271 for Laboratory Research
High Purity Alisol C CAS 30489271 is suited to laboratories using Alisol C as a triterpenoid reference standard in metabolic, hepatology, pharmacology, HPLC/MS, botanical-extract, or selected cell-line research. We explain the application fit and the identity, purity, physical form, solvent, endotoxin, storage, quantity, and batch-record checks to make before ordering.
Nov 02, 26
Reliable Oxandrolone Supplier for High Purity Pharmaceutical APIs
When sourcing high-purity pharmaceutical ingredients for endocrine or cardiovascular research, the reliability of the supply chain is as critical as the chemical purity itself. For laboratories and manufacturers seeking a dependable oxandrolone supplier, the focus must extend beyond simple certificates of analysis to encompass consistent batch-to-batch stability and strict adherence to GMP standards. Whether the requirement is for small-scale pilot studies or large-scale industrial production, the ability to trace materials from raw synthesis to final lyophilized powder ensures the integrity of the resulting clinical or research data.