Biotin-MBP Derivatized Peptide
TECHNICAL SPECIFICATIONS
| Item | Specification |
|---|---|
| Product Name | Biotin-MBP Derivatized Peptide |
| CAS NO. | \ |
| Appearance | White to off-white lyophilized powder |
| Molecular Formula | C105H166N28O25 |
| Molecular Weight | 2252.73g/mol |
| Purity (RP-HPLC) | ≥ 95.0% |
| Solubility | Soluble in water, 1% acetic acid, or DMSO |
| Endotoxin | < 1.0 EU/mg |
| Biological Activity | A biotinylated analog of myelin basic protein (MBP) fragments, designed for detection and purification in immunology research. It retains MHC class II binding and T-cell activation properties, while the biotin tag enables conjugation to streptavidin-coated surfaces for assays like ELISAs, pull-downs, and flow cytometry. |
| Storage Conditions | Store at -20°C in a desiccated environment. Avoid repeated freeze-thaw cycles. |
| Stock Location | Stock in USA |
| MOQ | 1g |
1.MECHANISM OF ACTION
The MBP fragment core of Biotin-MBP Derivatized Peptide binds to MHC class II molecules (e.g., I-Aᵘ, I-Eᵏ) with high affinity, mimicking native MBP epitopes to activate autoreactive CD4⁺ T cells—replicating the key immunological cascade in MS and EAE.
The covalently attached biotin tag does not interfere with the peptide’s biological activity; instead, it enables specific conjugation to streptavidin-coated surfaces, beads, or detection reagents (e.g., streptavidin-HRP, streptavidin-fluorophores).
This dual functionality allows researchers to both study the peptide’s immunological effects and track its interactions with target molecules (e.g., MHC proteins, T-cell receptors) via high-sensitivity assays
2.PRODUCT INDICATIONS
Research Use Only (RUO): For in vitro and in vivo studies of MS pathogenesis, EAE models, MHC-peptide-TCR interactions, and T-cell activation.
Ideal for assays requiring specific detection or purification, including ELISAs, pull-down assays, flow cytometry, immunoprecipitation, and peptide microarray immobilization.
Suitable for validating MBP-specific antibodies, screening immunomodulatory therapies, and investigating the role of MBP epitopes in autoimmune neuroinflammation.
Customizable for targeted research: available for biotinylation of any MBP fragment to match specific epitope interests.
3.CLINICAL EFFICACY OF PRODUCT
Biotin-MBP Derivatized Peptide is a preclinical research reagent and has not undergone human clinical trials.
In preclinical EAE models, it maintains the ability to induce or modulate autoimmune responses, serving as a valuable tool for evaluating the efficacy of potential MS therapies (e.g., peptide vaccines, monoclonal antibodies).
Its streptavidin-biotin conjugation capability enhances assay sensitivity, enabling accurate quantification of MHC-peptide binding affinity and T-cell activation—supporting the development and validation of novel immunotherapies.
4.DELIVERY & SHIPPING
We specialize in global logistics for various cosmetic peptides. Your order will be handled with the utmost care, ensuring safe, reliable, and intact delivery.
Professional and Secure Packaging
Each bottle of peptide is protected with a special packaging solution to ensure stability and integrity during transportation.
We can also customize packaging according to customer needs.
Shipping Methods
Main Method: International Air Freight
We primarily use DHL, FedEx, UPS, and TNT because of their global reliability, speed, and advanced tracking systems. Air freight ensures the fastest transit time and minimizes the impact of environmental factors on the product.
