Name: High-Purity Biotin-Neuropeptide Y for Metabolic Research
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Biotin-Neuropeptide Y (human, rat)

Biotin-Neuropeptide Y (human, rat) is a high-purity (up to ≥98% HPLC-MS verified) biotinylated peptide with molecular formula C₁₉₉H₃₀₀N₅₇O₆₀S₂ and molecular weight 4515.1 g/mol. As a cross-species active NPY receptor ligand, it retains native activity for appetite and metabolism regulation, with biotin modification enabling streptavidin-based tracing and purification. We are a trusted Biotin-NPY peptide supplier, offering custom biotinylated NPY service, bulk order options (5 mg–1 g), TFA-free customization, and rigorous quality control, with global shipping for neuroscience and metabolic research.

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TECHNICAL SPECIFICATIONS

Item	Specification
Product Name	Biotin-Neuropeptide Y (human, rat)
CAS NO.	\
Appearance	White to off-white lyophilized powder
Molecular Formula	C₁₉₉H₃₀₀N₅₇O₆₀S₂
Molecular Weight	4515.1g/mol
Purity (RP-HPLC)	≥ 95.0%
Solubility	Soluble in sterile water (≥1 mg/mL; ultrasonic treatment and warming to 37℃ recommended for full dissolution); soluble in DMSO and physiological buffers (PBS, pH 7.2-7.4); slightly soluble in ethanol; insoluble in non-polar solvents
Endotoxin	< 1.0 EU/mg
Biological Activity	Cross-species active; selective ligand for NPY receptors (Y1, Y2, Y4, Y5, Y6); retains native NPY activity to regulate appetite, energy metabolism, blood pressure, and neuronal signaling; Biotin moiety enables streptavidin/avidin-based tracing, purification and receptor binding analysis
Storage Conditions	-20℃ for short-term storage (2-3 years)
Stock Location	Stock in USA
MOQ	1g

1.MECHANISM OF ACTION

Biotin-Neuropeptide Y (human, rat) is a biotinylated 36-amino acid peptide (C-terminal amidated) with conserved cross-species activity, retaining the full biological function of native NPY while enabling streptavidin/avidin-based applications. It acts as a selective ligand for all NPY receptor subtypes (Y1, Y2, Y4, Y5, Y6), which are G-protein coupled receptors (GPCRs) widely expressed in the central nervous system, gastrointestinal tract, and cardiovascular system. Upon receptor binding, it activates Gi/o and Gq-dependent intracellular signaling pathways, inhibiting cyclic adenosine monophosphate (cAMP) production and modulating intracellular calcium levels to regulate downstream physiological processes.

2.PRODUCT INDICATIONS

Investigation of NPY receptor (Y1-Y6) signaling pathways and their roles in appetite regulation, energy homeostasis, and neuronal function

Streptavidin/avidin-based experiments: receptor localization (immunofluorescence), ligand-receptor binding assays, and NPY-associated protein purification

Screening and validation of NPY receptor agonists/antagonists via in vitro assays (calcium mobilization, cAMP inhibition, and competitive binding assays)

3.CLINICAL EFFICACY OF PRODUCT

In NPY receptor functional assays, it serves as a reliable positive control and tracing tool to evaluate the efficacy of NPY-targeted drug candidates for obesity, hypertension, and neurological disorders

In human and rat models of metabolic disorders, it aids in elucidating the role of NPY signaling in appetite and energy metabolism, supporting the development of anti-obesity therapeutics

Its streptavidin-binding property enables the development of high-sensitivity immunoassays for NPY-receptor interactions, laying the groundwork for clinical diagnostic tools in endocrinology and neuroscience

4.DELIVERY & SHIPPING

We specialize in global logistics for various cosmetic peptides. Your order will be handled with the utmost care, ensuring safe, reliable, and intact delivery.
Professional and Secure Packaging
Each bottle of peptide is protected with a special packaging solution to ensure stability and integrity during transportation.
We can also customize packaging according to customer needs.
Shipping Methods
Main Method: International Air Freight

We primarily use DHL, FedEx, UPS, and TNT because of their global reliability, speed, and advanced tracking systems. Air freight ensures the fastest transit time and minimizes the impact of environmental factors on the product.