Biotin-Substance P CAS NO.87468-58-4
TECHNICAL SPECIFICATIONS
| Item | Specification |
|---|---|
| Product Name | Biotin-Substance P |
| CAS NO. | 87468-58-4 |
| Appearance | White to off-white lyophilized powder |
| Molecular Formula | C73H112N20O15S2 |
| Molecular Weight | 1573.96/mol |
| Purity (RP-HPLC) | ≥95% |
| Solubility | Soluble in deionized water, PBS, and DMSO; stable in aqueous buffer systems |
| Endotoxin | ≤1.0 EU/mg |
| Biological Activity | Retains full agonist activity at NK1 receptor; biotin moiety enables high-affinity binding to streptavidin/avidin |
| Storage Conditions | Store at -20°C in a dry, dark place; avoid repeated freeze-thaw cycles |
| Stock Location | Stock in USA |
| MOQ | 1g |
1.MECHANISM OF ACTION
The mechanism of action of Biotin-Substance P centers on its interaction with the Neurokinin 1 Receptor (NK1R). Upon binding to NK1R, which is widely expressed in neurons, glial cells, and immune cells, it activates downstream signaling pathways involving G-proteins. This activation triggers physiological responses such as neurogenic inflammation, pain perception modulation, and immune cell recruitment. The biotin tag facilitates the visualization and quantification of these receptor-ligand interactions through streptavidin-based detection systems, allowing researchers to track receptor internalization and recycling dynamics .
2.PRODUCT INDICATIONS
3.CLINICAL EFFICACY OF PRODUCT
In clinical research contexts, Biotin-Substance P has demonstrated efficacy as a sensitive probe for detecting Substance P-related pathologies. Studies utilizing this conjugate have successfully elucidated elevated Substance P levels in conditions like inflammatory bowel disease and asthma, correlating with disease severity. Its utility in high-throughput screening and immunohistochemistry has validated its role in identifying therapeutic targets and assessing the efficacy of NK1R antagonists in mitigating pain and inflammation .
4.Certificate
GlobalTech Co., Ltd. is committed to providing high-purity biotechnological peptide products, adhering strictly to quality standards and obtaining internationally recognized certifications.
Our production partners all employ GMP-compliant production systems and possess standardized quality control processes covering raw material procurement, synthesis, purification, testing, packaging, and storage. Each batch of product comes with complete documentation, including a Certificate of Analysis (COA), HPLC purity report, mass spectrometry (MS) chromatograms, and third-party testing reports available upon request.
We prioritize:
1.A rigorous quality management system
2.Batch traceability and stability data
3.Professional laboratory testing and validation
4.Compliance with international trade standards
Our commitment to quality, transparency, and regulatory compliance ensures the provision of reliable, stable, and research-grade peptide products to our global partners.
5.DELIVERY & SHIPPING
We specialize in global logistics for various cosmetic peptides. Your order will be handled with the utmost care, ensuring safe, reliable, and intact delivery.
Professional and Secure Packaging
Each bottle of peptide is protected with a special packaging solution to ensure stability and integrity during transportation.
We can also customize packaging according to customer needs.
Shipping Methods
Main Method: International Air Freight
We primarily use DHL, FedEx, UPS, and TNT because of their global reliability, speed, and advanced tracking systems. Air freight ensures the fastest transit time and minimizes the impact of environmental factors on the product.
Global Technology Co., Ltd. is a modern and advanced enterprise specializing in the production and export of active pharmaceutical ingredients (APIs), peptides, and plant extracts. The company invests in and collaborates closely with domestic manufacturers holding GMP, DMF, and FDA certifications, as well as laboratories at renowned universities, to meet diverse customer needs ranging from gram-level to ton-level. This enables Dejurui Pharmaceutical to provide customers with more flexible and convenient access to cost-effective, high-quality products and superior services.
We focus on the research and development and supply of high-quality chemical products, strictly adhering to international standards and quality systems. Our products are stable in performance and reliable in purity, widely used in industrial manufacturing, scientific research, and the fine chemical industry. We provide solid support at every stage with a professional and responsible attitude.
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