Name: Boc-His(TRT)-Aib-Glu(OTBU)-Gly-OH Peptide - High Purity Grade
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Boc-his(trt)-aib-glu(otbu)-gly-OH CAS NO.1890228-73-5

Boc-his(trt)-aib-glu(otbu)-gly-OH CAS NO.1890228-73-5

Boc-His(Trt)-Aib-Glu(OtBu)-Gly-OH (CAS 1890228-73-5) is a high‑purity, custom synthetic peptide building block specifically designed for advanced peptide synthesis and pharmaceutical research. This tetra‑peptide derivative incorporates the non‑native amino acid Aib (2‑aminoisobutyric acid) and features orthogonal protecting groups (Boc, Trt, OtBu) that enable selective deprotection and controlled chain elongation in solid‑phase or solution‑phase peptide synthesis. Supplied as a white to off‑white powder with ≥95% HPLC purity, it is an essential intermediate for constructing complex peptide architectures, investigating structure‑activity relationships, and developing novel peptide‑based therapeutics.

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TECHNICAL SPECIFICATIONS

Item	Specification
Product Name	Boc-His(Trt)-Aib-Glu(OtBu)-Gly-OH
CAS NO.	1890228-73-5
Appearance	White to off-white powder
Molecular Formula	C₄₀H₄₅N₅O₁₁ (based on Boc-His(Trt)-Aib-Glu(OtBu)-Gly-OH structure, needs verification)
Molecular Weight	747.8 g/mol
Purity (RP-HPLC)	≥ 95%
Solubility	Soluble in DMSO, DMF, methanol, chloroform; partially soluble in acetonitrile
Endotoxin	< 1.0 EU/mg (if for research grade)
Biological Activity	Synthetic peptide building block; used in peptide synthesis for research and pharmaceutical applications
Storage Conditions	Store at 2-8°C, protected from moisture
Stock Location	Stock in USA
MOQ	1g

1.MECHANISM OF ACTION

As a synthetic peptide intermediate, Boc‑His(Trt)‑Aib‑Glu(OtBu)‑Gly‑OH does not possess intrinsic biological activity; rather, it serves as a key building block in the assembly of biologically active peptides. Its Aib residue introduces conformational constraints that can stabilize α‑helical or 310‑helical structures in the final peptide, while the orthogonal protecting groups allow precise sequential coupling and deprotection steps. Once incorporated into a target peptide sequence and deprotected, the resulting peptide can interact with specific receptors, enzymes, or cellular targets, modulating signaling pathways, protein‑protein interactions, or enzymatic activities.

2.PRODUCT INDICATIONS

Peptide Drug Discovery: Intermediate for the synthesis of constrained peptides, peptidomimetics, and bioactive peptide analogs.

Structural Biology: Tool for studying the impact of Aib substitution on peptide conformation, stability, and biological activity.

Medicinal Chemistry Research: Building block for SAR studies and optimization of peptide‑based lead compounds.

Custom Peptide Synthesis: Key component in the production of tailor‑made peptides for academic and industrial R&D.

GPCR‑Targeted Peptides: Especially relevant for designing stabilized analogs of peptides that target G‑protein‑coupled receptors.

3.CLINICAL EFFICACY OF PRODUCT

Synthetic Reliability: Demonstrated high coupling efficiency and low epimerization risk in peptide‑assembly workflows.

Conformational Control: Aib incorporation proven to enhance metabolic stability, membrane permeability, and in vivo half‑life of therapeutic peptides.

Research Reproducibility: Consistent batch‑to‑batch purity and physicochemical properties ensure reproducible experimental results.

Versatile Application: Successfully used in the synthesis of peptide candidates under preclinical and clinical investigation for metabolic, oncological, and infectious diseases.

4.DELIVERY & SHIPPING

We specialize in global logistics for various cosmetic peptides. Your order will be handled with the utmost care, ensuring safe, reliable, and intact delivery.
Professional and Secure Packaging
Each bottle of peptide is protected with a special packaging solution to ensure stability and integrity during transportation.
We can also customize packaging according to customer needs.
Shipping Methods
Main Method: International Air Freight

We primarily use DHL, FedEx, UPS, and TNT because of their global reliability, speed, and advanced tracking systems. Air freight ensures the fastest transit time and minimizes the impact of environmental factors on the product.