Bradykinin CAS NO.58-82-2
TECHNICAL SPECIFICATIONS
| Item | Specification |
|---|---|
| Product Name | Bradykinin |
| CAS NO. | 58-82-2 |
| Appearance | White to off-white lyophilized powder |
| Molecular Formula | C50H73N15O11 |
| Molecular Weight | 1060.22g/mol |
| Purity (RP-HPLC) | ≥ 95.0% |
| Solubility | Soluble in water, PBS, or dilute acetic acid. It is recommended to dissolve in sterile water or buffer to prepare stock solutions for biological assays. |
| Endotoxin | < 1.0 EU/mg (Typical for research-grade peptides) |
| Biological Activity | Bradykinin is a potent vasodilator and smooth muscle contractor. It is used in research to study inflammation, pain pathways, vascular permeability, and the kallikrein-kinin system. |
| Storage Conditions | Store at -20°C or lower. For long-term storage, keep desiccated at -20°C. Upon reconstitution, aliquot and store at -20°C to avoid repeated freeze-thaw cycles. |
| Stock Location | Stock in USA |
| MOQ | 1g |
1.MECHANISM OF ACTION
Bradykinin exerts its biological effects primarily by binding to and activating the B2 receptor (B2R), with a selectivity over the B1 receptor (B1R) exceeding 10,000-fold. Upon binding, it triggers downstream signaling cascades that lead to the release of nitric oxide (NO) and prostaglandins, resulting in vasodilation, increased vascular permeability, and the induction of pain and inflammatory responses. This mechanism is fundamental to its role in physiological and pathological processes.
2.PRODUCT INDICATIONS
This product is indicated for in vitro and in vivo research applications, particularly in the fields of cardiovascular biology, inflammation, and pain research. It is commonly used in animal models of chronic pain, sepsis, asthma, rheumatoid arthritis, and pancreatitis to elucidate disease mechanisms and evaluate potential therapeutic interventions. Additionally, it serves as a valuable reagent for studying the kallikrein-kinin system and its involvement in various pathological conditions.
3.CLINICAL EFFICACY OF PRODUCT
Bradykinin is a research-grade biochemical reagent and is not intended for diagnostic or therapeutic use in humans. Its clinical relevance lies in its role as a biomarker and a research tool for understanding disease mechanisms. While alterations in bradykinin levels are associated with conditions such as cirrhosis and chronic nephritis, and it has been studied in contexts like myocardial infarction and heart failure, the peptide itself does not possess established clinical efficacy as a therapeutic agent.
4.DELIVERY & SHIPPING
We specialize in global logistics for various cosmetic peptides. Your order will be handled with the utmost care, ensuring safe, reliable, and intact delivery.
Professional and Secure Packaging
Each bottle of peptide is protected with a special packaging solution to ensure stability and integrity during transportation.
We can also customize packaging according to customer needs.
Shipping Methods
Main Method: International Air Freight
We primarily use DHL, FedEx, UPS, and TNT because of their global reliability, speed, and advanced tracking systems. Air freight ensures the fastest transit time and minimizes the impact of environmental factors on the product.
