Brassicasterol CAS NO.474-67-9
TECHNICAL SPECIFICATIONS
| Item | Specification |
|---|---|
| Product Name | Brassicasterol |
| CAS NO. | 474-67-9 |
| Appearance | White to off-white crystalline powder |
| Molecular Formula | C28H46O |
| Molecular Weight | 398.675 g/mol |
| Purity (RP-HPLC) | ≥98.0% |
| Solubility | Soluble in chloroform, methanol, ethanol, acetone; insoluble in water |
| Endotoxin | ≤5 EU/mg |
| Biological Activity | Antioxidant, anti-inflammatory, inhibits cholesterol absorption, potential anti-cancer effects |
| Storage Conditions | Store at -20°C, protected from light and moisture |
| Stock Location | Stock in USA |
| MOQ | 1g |
1.MECHANISM OF ACTION
The primary biological mechanism of Brassicasterol involves its structural mimicry of cholesterol, allowing it to competitively inhibit the intestinal absorption of cholesterol by displacing it from mixed micelles, which subsequently reduces the overall serum LDL cholesterol pool and upregulates hepatic LDL receptor clearance. Additionally, it acts as a specific inhibitor of the enzyme sterol Δ24-reductase (with a noted Ki value of 42.7 μM), disrupting mammalian cholesterol biosynthesis pathways by causing the accumulation of desmosterol and directly modulating sterol regulatory element-binding proteins (SREBPs). Beyond lipid metabolism, the compound exerts cellular effects by dual-targeting the AKT and androgen receptor (AR) signaling pathways to induce G1 cell cycle arrest and apoptosis in cancer cells, while also demonstrating the capacity to inhibit vital enzymes involved in HSV-1 viral replication and Mycobacterium tuberculosis cell wall biosynthesis.
2.PRODUCT INDICATIONS
3.CLINICAL EFFICACY OF PRODUCT
As a raw phytosterol reference standard not formulated for human therapeutic administration, Brassicasterol does not possess approved clinical efficacy, yet it demonstrates significant bioactive potential in extensive preclinical in vitro and animal model studies. Experimental data indicate that it effectively lowers serum LDL cholesterol levels in models of hyperlipidemia via competitive micellar displacement and successfully inhibits the growth of prostate cancer (LNCaP) and bladder cancer cells by inducing apoptosis and suppressing AR/PSA expression. Additionally, research confirms its capacity to inhibit HSV-1 replication (IC50 = 1.2 μM) and Mycobacterium tuberculosis strains (MIC values 1.9–2.4 μM) in cellular assays, while altered concentrations of the compound in cerebrospinal fluid have been statistically linked to the prognosis of Alzheimer’s disease, validating its strong pharmacological and diagnostic relevance as a research tool rather than a direct clinical treatment.
4.Certificate
GlobalTech Co., Ltd. is committed to providing high-purity biotechnological peptide products, adhering strictly to quality standards and obtaining internationally recognized certifications.
Our production partners all employ GMP-compliant production systems and possess standardized quality control processes covering raw material procurement, synthesis, purification, testing, packaging, and storage. Each batch of product comes with complete documentation, including a Certificate of Analysis (COA), HPLC purity report, mass spectrometry (MS) chromatograms, and third-party testing reports available upon request.
We prioritize:
1.A rigorous quality management system
2.Batch traceability and stability data
3.Professional laboratory testing and validation
4.Compliance with international trade standards
Our commitment to quality, transparency, and regulatory compliance ensures the provision of reliable, stable, and research-grade peptide products to our global partners.
5.DELIVERY & SHIPPING
We specialize in global logistics for various cosmetic peptides. Your order will be handled with the utmost care, ensuring safe, reliable, and intact delivery.
Professional and Secure Packaging
Each bottle of peptide is protected with a special packaging solution to ensure stability and integrity during transportation.
We can also customize packaging according to customer needs.
Shipping Methods
Main Method: International Air Freight
We primarily use DHL, FedEx, UPS, and TNT because of their global reliability, speed, and advanced tracking systems. Air freight ensures the fastest transit time and minimizes the impact of environmental factors on the product.
Global Technology Co., Ltd. is a modern and advanced enterprise specializing in the production and export of active pharmaceutical ingredients (APIs), peptides, and plant extracts. The company invests in and collaborates closely with domestic manufacturers holding GMP, DMF, and FDA certifications, as well as laboratories at renowned universities, to meet diverse customer needs ranging from gram-level to ton-level. This enables Dejurui Pharmaceutical to provide customers with more flexible and convenient access to cost-effective, high-quality products and superior services.
We focus on the research and development and supply of high-quality chemical products, strictly adhering to international standards and quality systems. Our products are stable in performance and reliable in purity, widely used in industrial manufacturing, scientific research, and the fine chemical industry. We provide solid support at every stage with a professional and responsible attitude.
Hot Tags: Phytosterol, Plant Sterol, Lipid Metabolism, Cholesterol Lowering, Anticancer, Anti-infective, Biomarker, Research Chemical, Natural Product, GC-MS Standard, Androgen Receptor, Alzheimer's Biomarker.
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