Calcineurin Substrate CAS NO.113873-67-9
TECHNICAL SPECIFICATIONS
| Item | Specification |
|---|---|
| Product Name | Calcineurin Substrate |
| CAS NO. | 113873-67-9 |
| Appearance | White to off-white lyophilized powder |
| Molecular Formula | C₅₄H₈₉N₁₅O₁₆ |
| Molecular Weight | 1208.37 g /mol |
| Purity (RP-HPLC) | ≥98% |
| Solubility | Soluble in water, dilute acetic acid, or DMSO |
| Endotoxin | ≤1.0 EU/mg |
| Biological Activity | A highly specific peptide substrate for calcineurin (protein phosphatase 2B); used to quantify calcineurin activity in enzymatic assays by monitoring dephosphorylation of its arginine-rich motif. |
| Storage Conditions | Store at -20°C to -80°C in a dry environment. Lyophilized powder is stable for 24 months at -20°C. Reconstituted solutions should be stored at -20°C and used within 3 months, avoiding repeated freeze-thaw cycles. |
| Stock Location | Stock in USA |
| MOQ | 1g |
1.MECHANISM OF ACTION
This peptide functions as a direct biochemical substrate. It contains a phospho-serine/threonine residue that mimics a natural phosphorylation site on calcineurin's physiological targets (e.g., NFAT, DARPP-32). In the presence of active calcineurin, calcium, and calmodulin, the enzyme catalyzes the hydrolysis of the phosphate group from the peptide. This dephosphorylation reaction can be quantitatively measured using various detection methods (e.g., malachite green for free phosphate release, fluorescence, or absorbance change with coupled enzyme systems), providing a direct readout of calcineurin phosphatase activity.
2.PRODUCT INDICATIONS
3.CLINICAL EFFICACY OF PRODUCT
The Calcineurin Substrate peptide itself is not a therapeutic but a critical diagnostic and research reagent. Its "efficacy" is defined by its role in enabling the accurate measurement of calcineurin activity. This is directly applied in: 1) Therapeutic Drug Monitoring (TDM): Assays using this substrate are fundamental for monitoring the pharmacodynamic effect of calcineurin inhibitors (CNIs) like tacrolimus and cyclosporin in transplant patients, ensuring optimal immunosuppression. 2) Drug Discovery: It is indispensable for screening and developing new immunosuppressive agents. 3) Disease Research: It aids in studying pathological calcineurin signaling in cardiac, neurological, and autoimmune disorders.
4.DELIVERY & SHIPPING
We specialize in global logistics for various cosmetic peptides. Your order will be handled with the utmost care, ensuring safe, reliable, and intact delivery.
Professional and Secure Packaging
Each bottle of peptide is protected with a special packaging solution to ensure stability and integrity during transportation.
We can also customize packaging according to customer needs.
Shipping Methods
Main Method: International Air Freight
We primarily use DHL, FedEx, UPS, and TNT because of their global reliability, speed, and advanced tracking systems. Air freight ensures the fastest transit time and minimizes the impact of environmental factors on the product.
