Calmodulin-Dependent Protein Kinase II (281-309) CAS NO.116826-37-0
TECHNICAL SPECIFICATIONS
| Item | Specification |
|---|---|
| Product Name | Calmodulin-Dependent Protein Kinase II (281-309) |
| CAS NO. | 116826-37-0 |
| Appearance | White to off-white lyophilized powder |
| Molecular Formula | C146H254N46O39S3 |
| Molecular Weight | 3374.11/mol |
| Amino Acid Sequence | R‑Q‑E‑I‑T‑V‑K‑K‑L‑K‑Q‑L‑K‑T‑N‑L‑L‑I‑A‑K‑T‑V‑K‑E‑G‑L‑A‑Q‑E‑T (single‑letter notation, corresponding to CaMKII residues 281‑309) |
| Purity (RP-HPLC) | ≥95.0% |
| Solubility | Soluble in water, PBS, or dilute acetic acid solution; may require brief sonication |
| Endotoxin | ≤1.0 EU/mg |
| Biological Activity | Synthetic peptide corresponding to a functional region of CaMKII; used as substrate, inhibitor, or antigen in kinase studies, signal transduction research, and antibody production. |
| Storage Conditions | Store at –20°C, protected from light and moisture. For long-term storage, recommend –80°C. |
| Stock Location | Stock in USA |
| MOQ | 10mg |
1.MECHANISM OF ACTION
This peptide represents a functional sequence of CaMKII that binds to calmodulin in a calcium-dependent manner. Upon binding, it undergoes a conformational change that activates its kinase activity, leading to the phosphorylation of downstream target proteins and the regulation of various cellular processes, including synaptic transmission, gene expression, and cytoskeletal dynamics.
2.PRODUCT INDICATIONS
Calmodulin-Dependent Protein Kinase II (281-309) is used in research to investigate calcium-mediated signal transduction, neuronal function, and cellular regulation. It serves as a valuable tool in kinase activity assays, antibody production, and studies of diseases associated with CaMKII dysregulation, such as neurological and cardiac disorders.
3.CLINICAL EFFICACY OF PRODUCT
As a research reagent, this peptide is not intended for clinical use. Its value lies in enabling fundamental and translational research that contributes to the understanding of CaMKII's role in physiology and pathology, thereby supporting the future development of diagnostic and therapeutic strategies.
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