Cassiaside CAS NO.13709-03-0
TECHNICAL SPECIFICATIONS
| Item | Specification |
|---|---|
| Product Name | Cassiaside |
| CAS NO. | 13709-03-0 |
| Appearance | White to off-white crystalline powder / amorphous powder |
| Molecular Formula | C₂₁H₂₀O₁₀ |
| Molecular Weight | 432.38 g/mol |
| Purity (RP-HPLC) | ≥98.0% |
| Solubility | Soluble in methanol, ethanol, DMSO, and hot water; slightly soluble in cold water; insoluble in n-hexane, petroleum ether, chloroform |
| Endotoxin | < 1.0 EU/mg |
| Biological Activity | A major bioactive anthraquinone glycoside isolated from Cassia obtusifolia L. (Semen Cassiae), exhibits antioxidant, hepatoprotective, anti-inflammatory, and laxative activities in preclinical research |
| Storage Conditions | Store at 2-8 °C, sealed, protected from light and moisture; long-term storage at -20 °C is recommended to avoid degradation |
| Stock Location | Stock in USA |
| MOQ | 1g |
1.MECHANISM OF ACTION
Cassiaside functions as a mixed-type inhibitor of Beta-secretase 1 (BACE1), a key enzyme in amyloid-beta (Aβ) peptide production, with an IC₅₀ of approximately 4.45 μM (Ki ≈ 9.85 μM). By blocking the BACE1 cleavage site, it reduces the generation of neurotoxic Aβ plaques, a hallmark of Alzheimer's pathology. Additionally, it exhibits significant antioxidant and anti-inflammatory effects, protecting hepatocytes against D-galactosamine-induced injury by reducing oxidative stress and inflammatory cytokine release.
2.PRODUCT INDICATIONS
- Hepatoprotective Studies: Evaluation of liver protection against chemical-induced toxicity and oxidative damage.
- TCM & Nutraceutical QC: Certified reference standard for the identification and quantification of Cassia toraextracts and related herbal formulations.
Pharmaceutical Analysis: System suitability standard for HPLC and LC-MS analysis of naphthopyrone glycosides.
3.CLINICAL EFFICACY OF PRODUCT
In preclinical studies, Cassiaside demonstrates potent efficacy as a BACE1 inhibitor, effectively reducing Aβ production in enzyme activity assays. In hepatoprotection models, it significantly attenuates D-galactosamine-induced liver injury by lowering serum ALT/AST levels and improving histological damage. Its research "efficacy" is defined by its high binding affinity to BACE1 and reproducible bioactivity in validating the pharmacological quality of Cassia seed resources.
4.Certificate
GlobalTech Co., Ltd. is committed to providing high-purity biotechnological peptide products, adhering strictly to quality standards and obtaining internationally recognized certifications.
Our production partners all employ GMP-compliant production systems and possess standardized quality control processes covering raw material procurement, synthesis, purification, testing, packaging, and storage. Each batch of product comes with complete documentation, including a Certificate of Analysis (COA), HPLC purity report, mass spectrometry (MS) chromatograms, and third-party testing reports available upon request.
We prioritize:
1.A rigorous quality management system
2.Batch traceability and stability data
3.Professional laboratory testing and validation
4.Compliance with international trade standards
Our commitment to quality, transparency, and regulatory compliance ensures the provision of reliable, stable, and research-grade peptide products to our global partners.
5.DELIVERY & SHIPPING
We specialize in global logistics for various cosmetic peptides. Your order will be handled with the utmost care, ensuring safe, reliable, and intact delivery.
Professional and Secure Packaging
Each bottle of peptide is protected with a special packaging solution to ensure stability and integrity during transportation.
We can also customize packaging according to customer needs.
Shipping Methods
Main Method: International Air Freight
We primarily use DHL, FedEx, UPS, and TNT because of their global reliability, speed, and advanced tracking systems. Air freight ensures the fastest transit time and minimizes the impact of environmental factors on the product.
Global Technology Co., Ltd. is a modern and advanced enterprise specializing in the production and export of active pharmaceutical ingredients (APIs), peptides, and plant extracts. The company invests in and collaborates closely with domestic manufacturers holding GMP, DMF, and FDA certifications, as well as laboratories at renowned universities, to meet diverse customer needs ranging from gram-level to ton-level. This enables Dejurui Pharmaceutical to provide customers with more flexible and convenient access to cost-effective, high-quality products and superior services.
We focus on the research and development and supply of high-quality chemical products, strictly adhering to international standards and quality systems. Our products are stable in performance and reliable in purity, widely used in industrial manufacturing, scientific research, and the fine chemical industry. We provide solid support at every stage with a professional and responsible attitude.
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