Cecropin A CAS 80451043 High Purity AMP Peptide China Suppliers Factory
Cecropin A (CAS NO. 80451-04-3) is a high-purity antimicrobial peptide (AMP) engineered for advanced laboratory research and preclinical studies. Characterized by its potent broad-spectrum antibacterial activity, particularly against Gram-negative bacteria, this cationic peptide utilizes a unique membrane-disruption mechanism to bypass traditional antibiotic resistance, making it an indispensable tool for researchers focusing on membrane biology and next-generation anti-infective agents.
Designed for rigorous scientific applications, Cecropin A exhibits significant efficacy in inducing apoptosis in various human cancer cell lines and modulating immune responses. With a purity level of ≥98.0% as verified by RP-HPLC, it serves as a critical reference standard for determining minimum inhibitory concentrations (MICs) and investigating the structure-activity relationships of amphipathic peptides in biotechnological and pharmaceutical settings.
Detailed Parameters
| Product Name | Cecropin A | CAS NO. | 80451-04-3 |
|---|---|---|---|
| Appearance | White to off-white powder | Molecular Formula | C184H313N53O46 |
| Molecular Weight | 4003.84 g/mol | Purity (RP-HPLC) | ≥98.0% |
| Solubility | Water, dilute acetic acid | Endotoxin | ≤0.5 EU/mg |
| Storage | -20°C, dry, dark | MOQ | 1g |
Key Advantages
Anti-Resistance Mode
Utilizes physical membrane disruption (toroidal pores) rather than metabolic targeting, reducing the risk of microbial resistance.
Rapid Bactericidal Effect
Achieves fast osmotic lysis of target cells, demonstrating high efficacy against ESKAPE organisms and MDR isolates.
Multi-Functional Use
Beyond antimicrobial action, it shows promising anticancer properties and immunomodulatory functions in macrophage models.
Ultra-High Purity
Strict ≥98.0% RP-HPLC purity ensures reliable and reproducible results in sensitive biochemical assays.
Low Endotoxicity
Maintained at ≤0.5 EU/mg, ensuring minimal interference in cell-based assays and preclinical animal models.
Full Traceability
Each batch is accompanied by a comprehensive COA, MS chromatograms, and HPLC purity reports for total transparency.
Product Gallery
Management Platforms
GMP Compliant Systems
Production processes adhere to strict GMP standards for raw materials and synthesis.
Quality Control (QC)
Standardized validation covering purification, testing, and stability monitoring.
Batch Traceability
Rigorous documentation and stability data provided for every unique production lot.
Global Logistics
Specialized cold-chain shipping via DHL/FedEx to maintain peptide integrity.
Flexible Scaling
Capability to supply from milligram research levels up to ton-level industrial production.
Expert Collaboration
R&D partnerships with top universities to ensure cutting-edge peptide synthesis.
Investment Return Comparison
| Metric | Traditional Antibiotics | Cecropin A (AMPs) |
|---|---|---|
| Resistance Risk | High (Enzyme-based) | Very Low (Physical) |
| Spectrum | Target-Specific | Broad Spectrum |
| Action Speed | Metabolic (Slower) | Membrane Lysis (Rapid) |
| Versatility | Anti-bacterial only | Antibacterial + Anticancer |
| Development Potential | Declining Efficiency | High Growth Potential |
Frequently Asked Questions
It is primarily used as a lead compound for antimicrobial discovery, a reference peptide for MIC assays, and in the study of membrane-active peptide interactions within pharmaceutical R&D.
Unlike conventional drugs that target specific enzymes, Cecropin A disrupts the bacterial cell membrane physically, creating pores that lead to osmotic lysis, which significantly hinders the development of resistance.
Cecropin A should be stored at -20°C in a dry, dark, and well-sealed container. It is critical to avoid repeated freeze-thaw cycles to maintain biological activity.
No, this product is currently designated strictly for research use (RUO) and preclinical studies. It has not received regulatory approval for clinical therapeutic use.
It shows potent activity against a broad spectrum of pathogens, including E. coli, P. aeruginosa, A. baumannii, and S. aureus, with MICs typically between 1 to 3 μM.
Each batch comes with a Certificate of Analysis (COA), an RP-HPLC purity report, and mass spectrometry (MS) chromatograms to ensure compliance with international standards.
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