Clematichinenoside AR CAS NO.761425-93-8
TECHNICAL SPECIFICATIONS
| Item | Specification |
|---|---|
| Product Name | Clematichinenoside AR |
| CAS NO. | 761425-93-8 |
| Appearance | White to off-white crystalline powder |
| Molecular Formula | C₅₉H₉₆O₂₆ |
| Molecular Weight | 1225.37 g/mol |
| Purity (RP-HPLC) | ≥ 98.0% |
| Solubility | Soluble in methanol, ethanol, DMSO; slightly soluble in water |
| Endotoxin | < 1.0 EU/mg |
| Biological Activity | Confirmed anti-inflammatory, neuroprotective, and cardioprotective activity in in vitro studies |
| Storage Conditions | Store at -20°C, sealed and protected from light; avoid repeated freeze-thaw cycles |
| Stock Location | Stock in USA |
| MOQ | 1g |
1.MECHANISM OF ACTION
Clematichinenoside AR exerts its pharmacological effects through the multi-pathway modulation of inflammatory and immune responses. Its primary action involves the potent inhibition of the NF-κB signaling pathway, leading to the downregulation of key pro-inflammatory cytokines (e.g., TNF-α, IL-1β, IL-6) and enzymes like COX-2 and iNOS. It also modulates MAPK and JAK-STAT signaling cascades. Furthermore, it suppresses the activation and migration of immune cells such as macrophages and neutrophils, and inhibits the production of matrix metalloproteinases (MMPs), thereby protecting cartilage and bone from degradation.
2.PRODUCT INDICATIONS
- Rheumatology Research: Investigation of mechanisms and therapeutics for rheumatoid arthritis (RA), osteoarthritis (OA), and gout.
- Immunopharmacology: Study of immunomodulatory effects on macrophages, T-cells, and inflammatory signaling.
- Analgesic Research: Evaluation of peripheral and central analgesic mechanisms.
- Pharmaceutical QC: Certified reference standard for the authentication and quality control of Clematisspecies extracts and related herbal products.
3.CLINICAL EFFICACY OF PRODUCT
Robust preclinical in vitro and in vivo studies substantiate the efficacy of Clematichinenoside AR. In rodent models of collagen-induced arthritis (CIA) and monosodium iodoacetate (MIA)-induced osteoarthritis, it significantly reduces joint swelling, pain sensitivity, synovial inflammation, and bone/cartilage destruction. It demonstrates a favorable safety profile with notable analgesic effects comparable to some NSAIDs. These promising results highlight its potential as a novel therapeutic agent for autoimmune and inflammatory joint diseases, warranting further clinical development.
4.Certificate
GlobalTech Co., Ltd. is committed to providing high-purity biotechnological peptide products, adhering strictly to quality standards and obtaining internationally recognized certifications.
Our production partners all employ GMP-compliant production systems and possess standardized quality control processes covering raw material procurement, synthesis, purification, testing, packaging, and storage. Each batch of product comes with complete documentation, including a Certificate of Analysis (COA), HPLC purity report, mass spectrometry (MS) chromatograms, and third-party testing reports available upon request.
We prioritize:
1.A rigorous quality management system
2.Batch traceability and stability data
3.Professional laboratory testing and validation
4.Compliance with international trade standards
Our commitment to quality, transparency, and regulatory compliance ensures the provision of reliable, stable, and research-grade peptide products to our global partners.
5.DELIVERY & SHIPPING
We specialize in global logistics for various cosmetic peptides. Your order will be handled with the utmost care, ensuring safe, reliable, and intact delivery.
Professional and Secure Packaging
Each bottle of peptide is protected with a special packaging solution to ensure stability and integrity during transportation.
We can also customize packaging according to customer needs.
Shipping Methods
Main Method: International Air Freight
We primarily use DHL, FedEx, UPS, and TNT because of their global reliability, speed, and advanced tracking systems. Air freight ensures the fastest transit time and minimizes the impact of environmental factors on the product.
Global Technology Co., Ltd. is a modern and advanced enterprise specializing in the production and export of active pharmaceutical ingredients (APIs), peptides, and plant extracts. The company invests in and collaborates closely with domestic manufacturers holding GMP, DMF, and FDA certifications, as well as laboratories at renowned universities, to meet diverse customer needs ranging from gram-level to ton-level. This enables Dejurui Pharmaceutical to provide customers with more flexible and convenient access to cost-effective, high-quality products and superior services.
We focus on the research and development and supply of high-quality chemical products, strictly adhering to international standards and quality systems. Our products are stable in performance and reliable in purity, widely used in industrial manufacturing, scientific research, and the fine chemical industry. We provide solid support at every stage with a professional and responsible attitude.
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