Collagen Type II Fragment CAS NO.144703-90-2
Collagen Type II Fragment CAS NO.144703-90-2
TECHNICAL SPECIFICATIONS
| Item | Specification |
|---|---|
| Product Name | Collagen Type II Fragment |
| CAS NO. | 144703-90-2 |
| Appearance | White to off-white lyophilized powder |
| Molecular Formula | C₁₀₆H₁₇₄N₃₂O₃₇ |
| Molecular Weight | 2488.71g/mol |
| Purity (RP-HPLC) | ≥ 95.0% |
| Solubility | Soluble in water (≥5 mg/mL) or 5% acetic acid; also soluble in DMSO |
| Endotoxin | < 1.0 EU/mg |
| Biological Activity | A peptide analog of the antigenic determinant of type II collagen, with anti-inflammatory properties; effectively inhibits collagen-induced arthritis in mice; useful for research focused on inflammation, immunity, and autoimmune diseases |
| Storage Conditions | Store at -20°C ; avoid repeated freeze-thaw cycles; store as aliquots in sealed vials, protected from light and moisture |
| Stock Location | Stock in USA |
| MOQ | 1g |
1.MECHANISM OF ACTION
This collagen fragment operates primarily as an autoantigen to drive an antigen-specific immune response in animal models:
- Antigen Presentation & T-Cell Activation: When administered with an adjuvant (like Complete Freund's Adjuvant), the fragment is taken up by antigen-presenting cells (APCs), processed, and its peptides are presented on MHC Class II molecules.
- Activation of Autoreactive CD4+ T-Cells: The presented epitopes activate collagen-specific CD4+ T helper cells, particularly of the Th1 and Th17 subtypes, which are pro-inflammatory.
- B-Cell Activation & Autoantibody Production: Activated T-cells provide help to autoreactive B-cells, leading to the production of anti-collagen type II antibodies. These antibodies form immune complexes in the joint.
Induction of Inflammatory Arthritis: The activated T-cells, autoantibodies, and immune complexes drive a sustained inflammatory response in the synovium of joints, characterized by infiltration of immune cells, synovial hyperplasia, cartilage erosion, and bone destruction. This recapitulates key features of human rheumatoid arthritis.
2.PRODUCT INDICATIONS
This product is specifically indicated for autoimmunity and arthritis research using animal models. Key applications include:
- Induction of Collagen-Induced Arthritis (CIA): As the primary immunogen to induce the gold-standard murine model of rheumatoid arthritis for studying disease pathogenesis and progression.
- Pathogenesis Studies: Investigating the roles of T-cells, B-cells, cytokines, and signaling pathways in autoimmune joint inflammation.
- Therapeutic Evaluation: Screening and testing the efficacy of novel disease-modifying anti-rheumatic drugs (DMARDs), biologics, tolerogenic vaccines, or other immunomodulatory therapies in a pre-clinical, antigen-specific model.
- Immune Tolerance Research: Studying mechanisms of oral tolerance, nasal tolerance, or other antigen-specific tolerance induction strategies using this defined antigen.
- Diagnostic Research: Potentially used in the development of assays to detect collagen-specific autoantibodies.
3.CLINICAL EFFICACY OF PRODUCT
The Collagen Type II Fragment itself is not a clinical therapeutic; it is a pre-clinical research antigen. Its profound "efficacy" is defined by its unparalleled ability to generate a validated and translational animal model of human disease.
- Validated Disease Model: CIA induced with this fragment is the most widely used and well-characterized animal model for RA. It shares critical immunological and pathological features with human RA, including:
- HLA association (in certain mouse strains).
- Role of autoreactive T and B cells.
- Production of rheumatoid factor (RF) and anti-citrullinated protein antibody (ACPA) analogs.
- Synovitis, pannus formation, cartilage/bone destruction.
- Predictive Value for Drug Discovery: Virtually all current biological therapies for RA (e.g., anti-TNFα, anti-IL-6R, CTLA4-Ig) were first shown to be effective in the CIA model. The model's predictive validity for human therapeutic response is exceptionally high.
- Foundation for Tolerogenic Therapy: Research using this fragment in tolerance studies has directly informed the clinical development of oral collagen type II as an investigational tolerogenic therapy for RA.
4.DELIVERY & SHIPPING
We specialize in global logistics for various cosmetic peptides. Your order will be handled with the utmost care, ensuring safe, reliable, and intact delivery.
Professional and Secure Packaging
Each bottle of peptide is protected with a special packaging solution to ensure stability and integrity during transportation.
We can also customize packaging according to customer needs.
Shipping Methods
Main Method: International Air Freight
We primarily use DHL, FedEx, UPS, and TNT because of their global reliability, speed, and advanced tracking systems. Air freight ensures the fastest transit time and minimizes the impact of environmental factors on the product.
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