Corticostatin, rabbit CAS NO.61950-59-2

Corticostatin, rabbit CAS NO.61950-59-2

Corticostatin, rabbit CAS NO.61950-59-2

Corticostatin, rabbit CAS NO.61950-59-2

Corticostatin, rabbit CAS NO.61950-59-2

Rabbit Corticostatin is a cationic peptide belonging to the defensin family, originally isolated from rabbit fetal and adult lung tissues. It is characterized by its high arginine and cysteine content, forming a stable structure with three intramolecular disulfide bonds. This research-grade peptide is primarily utilized in endocrine and immunological studies to investigate the regulation of adrenal steroidogenesis and innate host defense mechanisms, serving as a critical tool for scientists exploring the intersection of neuroendocrine and immune systems.


TECHNICAL SPECIFICATIONS


Item
Specification
Product Name
Corticostatin, rabbit
CAS NO.
61950-59-2
Appearance
White to off-white lyophilized powder
Molecular Formula
C₁₆₃H₂₆₅N₆₃O₄₄S₆
Molecular Weight
3965.8g/mol
Purity (RP-HPLC)
≥90.0% (typical specification, may vary by supplier)
Solubility

Soluble in dilute acetic acid or 0.1% TFA in water; soluble in 1,2-dichloroethane/water mixture

Endotoxin
≤1 EU/mg (LAL test)
Biological Activity
Inhibits ACTH-induced corticosteroidogenesis; exhibits antimicrobial activity
Storage Conditions
Lyophilized: -20°C; Reconstituted: 2–8°C, protect from light
Stock Location
Stock in USA
MOQ
1g


1.MECHANISM OF ACTION

The peptide functions as a specific antagonist of adrenocorticotropic hormone (ACTH) by competitively binding to the ACTH receptor on adrenal cortical cells, thereby inhibiting ACTH-stimulated cAMP production and subsequent corticosteroid synthesis. Beyond its endocrine role, as a member of the α-defensin family, it also exhibits antimicrobial activity by disrupting microbial membrane integrity and exerts immunomodulatory effects such as promoting monocyte chemotaxis and mast cell degranulation, highlighting its dual role in host defense.

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2.PRODUCT INDICATIONS

This product is indicated for in vitro research applications focused on hypothalamic-pituitary-adrenal (HPA) axis regulation, including studies on Cushing's syndrome, stress response, and inflammatory diseases. It is also employed in antimicrobial research to assess defensin-mediated immunity against bacteria, fungi, and viruses. Researchers in endocrinology, immunology, and infectious disease utilize it to elucidate the physiological roles of corticostatins in pregnancy, neutrophil function, and autoimmune conditions.

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3.CLINICAL EFFICACY OF PRODUCT

In experimental models, Rabbit Corticostatin demonstrates potent efficacy in suppressing ACTH-induced corticosterone and aldosterone production in rat adrenal cells, with an ED₅₀ in the nanomolar range. It effectively modulates immune responses by enhancing phagocytosis and exhibiting broad-spectrum microbicidal activity. While not a therapeutic agent itself, its robust bioactivity makes it a valuable reference compound for developing novel anti-inflammatory or antimicrobial agents targeting the defensin pathway.

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4.Certificate

GlobalTech Co., Ltd. is committed to providing high-purity biotechnological peptide products, adhering strictly to quality standards and obtaining internationally recognized certifications.


Our production partners all employ GMP-compliant production systems and possess standardized quality control processes covering raw material procurement, synthesis, purification, testing, packaging, and storage. Each batch of product comes with complete documentation, including a Certificate of Analysis (COA), HPLC purity report, mass spectrometry (MS) chromatograms, and third-party testing reports available upon request.


We prioritize:

1.A rigorous quality management system

2.Batch traceability and stability data

3.Professional laboratory testing and validation

4.Compliance with international trade standards


Our commitment to quality, transparency, and regulatory compliance ensures the provision of reliable, stable, and research-grade peptide products to our global partners.

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5.DELIVERY & SHIPPING

We specialize in global logistics for various cosmetic peptides. Your order will be handled with the utmost care, ensuring safe, reliable, and intact delivery.

Professional and Secure Packaging

Each bottle of peptide is protected with a special packaging solution to ensure stability and integrity during transportation.

We can also customize packaging according to customer needs.

Shipping Methods 

Main Method: International Air Freight

We primarily use DHL, FedEx, UPS, and TNT because of their global reliability, speed, and advanced tracking systems. Air freight ensures the fastest transit time and minimizes the impact of environmental factors on the product.

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Global Technology Co., Ltd. is a modern and advanced enterprise specializing in the production and export of active pharmaceutical ingredients (APIs), peptides, and plant extracts. The company invests in and collaborates closely with domestic manufacturers holding GMP, DMF, and FDA certifications, as well as laboratories at renowned universities, to meet diverse customer needs ranging from gram-level to ton-level. This enables Dejurui Pharmaceutical to provide customers with more flexible and convenient access to cost-effective, high-quality products and superior services.


We focus on the research and development and supply of high-quality chemical products, strictly adhering to international standards and quality systems. Our products are stable in performance and reliable in purity, widely used in industrial manufacturing, scientific research, and the fine chemical industry. We provide solid support at every stage with a professional and responsible attitude.


Hot Tags: RabbitCorticostatin, #Corticostatin, #Defensin, #ACTHAntagonist, #HPAAxis, #AntimicrobialPeptide, #ImmunomodulatoryPeptide, #ResearchPeptide

If you have any product requirements, please send an email to:support@huanqiukeji9.com;whatsapp:85244969439

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