Name: Corticotropin Releasing Factor, Ovine - CAS 9015-71-8
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Corticotropin Releasing Factor, ovine CAS NO.9015-71-8

Corticotropin Releasing Factor, ovine (oCRF) is a 41-amino acid neuropeptide hormone originally isolated from sheep hypothalamus, serving as a pivotal research tool for studying the hypothalamic-pituitary-adrenal (HPA) axis and stress response pathways. This synthetic peptide is characterized by its high affinity for CRF1 receptors and is widely utilized in neuroscience, endocrinology, and pharmacology to model physiological and behavioral responses to stress, making it essential for researchers investigating depression, anxiety, and neuroendocrine disorders.

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TECHNICAL SPECIFICATIONS

Item	Specification
Product Name	Corticotropin Releasing Factor, ovine
CAS NO.	9015-71-8
Appearance	White to off-white lyophilized powder
Molecular Formula	C₂₀₅H₃₃₉N₅₉O₆₃S
Molecular Weight	4750.5g/mol
Purity (RP-HPLC)	≥95%
Solubility	Soluble in water or dilute acid; stable at low pH (pH 4.0–6.0)
Endotoxin	≤1 EU/mg (LAL test)
Biological Activity	Potent agonist of ovine and human CRF receptors; stimulates ACTH release in vitro and in vivo
Storage Conditions	Store at -20°C, protected from light and moisture; avoid repeated freeze-thaw cycles
Stock Location	Stock in USA
MOQ	1g

1.MECHANISM OF ACTION

Ovine CRF functions as a preferential CRF1 receptor agonist, binding with high specificity to CRF receptors in the pituitary and brain to activate adenylate cyclase and increase intracellular cAMP levels. This signaling cascade stimulates the synthesis and release of adrenocorticotropic hormone (ACTH) and β-endorphin from the anterior pituitary, thereby initiating the HPA axis cascade that elevates glucocorticoid levels and modulates central nervous system activity, including autonomic and behavioral responses to stressors.

2.PRODUCT INDICATIONS

This product is indicated for preclinical research applications, including HPA axis functional testing, stress response modeling, and the screening of CRF receptor antagonists for therapeutic development. It is used in vitro for stimulating ACTH secretion in pituitary cell cultures and in vivo for studying anxiety-like behaviors, feeding suppression, and cardiovascular responses in animal models, providing critical insights for drug discovery in psychiatric and metabolic disorders.

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3.CLINICAL EFFICACY OF PRODUCT

In experimental settings, ovine CRF demonstrates potent bioactivity in elevating plasma ACTH and cortisol levels in various species, confirming its role as a robust HPA axis activator. Preclinical studies show its efficacy in inducing stress-related physiological and behavioral changes, such as reduced food intake and increased arousal, validating its utility as a reference standard for evaluating the efficacy of novel neuroendocrine modulators and anxiolytic compounds.

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4.Certificate

GlobalTech Co., Ltd. is committed to providing high-purity biotechnological peptide products, adhering strictly to quality standards and obtaining internationally recognized certifications.

Our production partners all employ GMP-compliant production systems and possess standardized quality control processes covering raw material procurement, synthesis, purification, testing, packaging, and storage. Each batch of product comes with complete documentation, including a Certificate of Analysis (COA), HPLC purity report, mass spectrometry (MS) chromatograms, and third-party testing reports available upon request.

We prioritize:

1.A rigorous quality management system

2.Batch traceability and stability data

3.Professional laboratory testing and validation

4.Compliance with international trade standards

Our commitment to quality, transparency, and regulatory compliance ensures the provision of reliable, stable, and research-grade peptide products to our global partners.

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5.DELIVERY & SHIPPING

We specialize in global logistics for various cosmetic peptides. Your order will be handled with the utmost care, ensuring safe, reliable, and intact delivery.

Professional and Secure Packaging

Each bottle of peptide is protected with a special packaging solution to ensure stability and integrity during transportation.

We can also customize packaging according to customer needs.

Shipping Methods

Main Method: International Air Freight

We primarily use DHL, FedEx, UPS, and TNT because of their global reliability, speed, and advanced tracking systems. Air freight ensures the fastest transit time and minimizes the impact of environmental factors on the product.

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Global Technology Co., Ltd. is a modern and advanced enterprise specializing in the production and export of active pharmaceutical ingredients (APIs), peptides, and plant extracts. The company invests in and collaborates closely with domestic manufacturers holding GMP, DMF, and FDA certifications, as well as laboratories at renowned universities, to meet diverse customer needs ranging from gram-level to ton-level. This enables Dejurui Pharmaceutical to provide customers with more flexible and convenient access to cost-effective, high-quality products and superior services.

We focus on the research and development and supply of high-quality chemical products, strictly adhering to international standards and quality systems. Our products are stable in performance and reliable in purity, widely used in industrial manufacturing, scientific research, and the fine chemical industry. We provide solid support at every stage with a professional and responsible attitude.

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