Cortistatin-29 (rat) CAS NO.1815618-17-7
TECHNICAL SPECIFICATIONS
| Item | Specification |
|---|---|
| Product Name | Cortistatin-29 (rat) |
| CAS NO. | 1815618-17-7 |
| Appearance | WWhite to off-white lyophilized powder |
| Molecular Formula | C161H240N46O41S2 |
| Molecular Weight | 3540.09g/mol |
| Purity (RP-HPLC) | ≥98% |
| Solubility | Soluble in water (≥1 mg/mL); reconstitute with sterile distilled water or buffer. |
| Endotoxin | < 1.0 EU/mg |
| Biological Activity | Binds all somatostatin receptor subtypes (SSTR1–SSTR5) with high affinity; IC₅₀ values: 2.8 nM (SSTR1), 7.1 nM (SSTR2), 0.2 nM (SSTR3), 3.0 nM (SSTR4), 13.7 nM (SSTR5). Exhibits anti-fibrotic and neuropathic pain-alleviating effects. |
| Storage Conditions | -20 ± 5 °C, lyophilized powder; avoid repeated freeze-thaw cycles. Stable for 12 months at -20 °C. |
| Stock Location | Stock in USA |
| MOQ | 1g |
1.MECHANISM OF ACTION
Cortistatin-29 exerts its effects through dual receptor pathways:
- Somatostatin Receptor (sst) Activation: Like somatostatin, it binds to and activates sst1-5 receptors, which are coupled to Gi/o proteins. This leads to inhibition of adenylyl cyclase, reduced cAMP levels, and modulation of calcium and potassium channels. This pathway mediates effects such as neuronal inhibition and reduced hormone secretion.
- Ghrelin Receptor (GHS-R1a) Interaction: A defining feature of cortistatin is its ability to bind to and act as an agonist or modulator at the GHS-R1a receptor. This interaction is implicated in its specific effects on sleep regulation, locomotor activity, and appetite, differentiating it from somatostatin.
2.PRODUCT INDICATIONS
This product is indicated for advanced research in neuroscience, immunology, and endocrinology. Key applications include:
- Neuroscience Research: Studying its role in sleep-wake cycles, cortical excitability, locomotor activity, and neuroprotection in rat models.
- Immune System Modulation: Investigating its potent anti-inflammatory and immunosuppressive effects on T-cells and macrophages, relevant to autoimmune disease and inflammation research.
- Endocrine Research: Exploring its effects on growth hormone release and other pituitary functions, often in comparison to somatostatin.
- Receptor Specificity Studies: Used to differentiate the roles of somatostatin receptors versus the ghrelin receptor in various physiological processes.
3.CLINICAL EFFICACY OF PRODUCT
- Target Validation: Studies with Cortistatin-29 have highlighted its unique anti-inflammatory and neuroprotective properties, suggesting that cortistatin-based therapies or GHS-R1a modulators could be developed for conditions like rheumatoid arthritis, multiple sclerosis, and neurodegenerative diseases.
- Biomarker Potential: Its expression patterns are being investigated as potential biomarkers for certain neurological and inflammatory disorders.
- Drug Discovery: It serves as the key reference compound for screening and developing novel, selective agonists or antagonists for the cortistatin/ghrelin receptor pathways.
4.DELIVERY & SHIPPING
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Professional and Secure Packaging
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Shipping Methods
Main Method: International Air Freight
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