CRAMP mouse CAS 376364362 High Purity Peptide China Suppliers Factory
CRAMP (mouse), identified by CAS NO. 376364-36-2, is a high-purity cationic antimicrobial peptide critical for advanced immunological and microbiological research. As a murine analog to human LL-37, this lyophilized powder is engineered to provide potent bactericidal activity against a wide spectrum of Gram-positive and Gram-negative pathogens, making it an indispensable reagent for studying innate immunity and mucosal homeostasis.
Beyond its direct antimicrobial properties, CRAMP operates through a sophisticated dual-action mechanism involving microbial membrane disruption and the modulation of host immune responses via Fpr2 receptors. From investigating multidrug-resistant bacterial biofilms to exploring tissue repair and intestinal inflammation in preclinical murine models, this research-grade peptide ensures precision and reproducibility in complex laboratory assays.
Detailed Parameters
| Product Name | CRAMP (mouse) | CAS NO. | 376364-36-2 |
|---|---|---|---|
| Molecular Formula | C178H302N50O46 | Molecular Weight | 3878.67 g/mol |
| Purity (RP-HPLC) | ≥99.0% | Appearance | White to off-white powder |
| Endotoxin | ≤0.5 EU/mg | Solubility | Water, dilute acetic acid, PBS |
| Storage | -20°C, dry and dark | MOQ | 1 kit |
Key Advantages
Broad-Spectrum Potency
Exhibits rapid bactericidal activity against E. coli, P. aeruginosa, and S. aureus without fostering resistance.
Rapid Membrane Lysis
Utilizes electrostatic attraction to create toroidal pores, leading to immediate osmotic lysis of target cells.
Immune Modulation
Triggers MAPK pathways and recruits neutrophils/macrophages via Fpr2 receptors for enhanced healing.
Mucosal Protection
Proven efficacy in protecting colon crypts and suppressing DSS-induced ulcerative colitis in murine systems.
Ultra-High Purity
≥99.0% purity verified by RP-HPLC and MS, ensuring consistent results in sensitive analytical assays.
Full Traceability
Every batch is accompanied by a COA and HPLC report for complete regulatory and research transparency.
Product Gallery
Management Platforms
GMP Production
All synthesis partners adhere to strict GMP-compliant systems for pharmaceutical grade quality.
Rigorous QC
Standardized quality control covering raw materials, purification, and stability testing.
Batch Validation
Comprehensive documentation including COA, MS chromatograms, and 3rd party reports.
Cold-Chain Logistics
Specialized packaging to maintain -20°C stability during international air freight.
Scalable Supply
Capabilities ranging from gram-level research quantities to ton-level industrial production.
Global Compliance
Strict adherence to international trade standards and FDA/DMF certified manufacturing sources.
Investment Return Comparison
| Feature Metric | Standard Peptides | GlobalTech CRAMP |
|---|---|---|
| Purity Level | < 95% | ≥ 99.0% (HPLC) |
| Endotoxin Control | Unspecified | ≤ 0.5 EU/mg |
| Bio-Activity | Variable | Potent/Validated |
| Documentation | Basic COA | COA + MS + HPLC |
| Delivery Speed | Standard Freight | Express Air Freight |
Frequently Asked Questions
It is primarily used as a reagent in in vitro laboratory research and preclinical animal models to study innate immunity, antimicrobial potency against drug-resistant bacteria, and the regulation of gut mucosal homeostasis.
CRAMP is the murine ortholog of human LL-37. While they share similar amphipathic alpha-helical structures and antimicrobial functions, CRAMP is specifically optimized for use in mouse-based biological systems.
It should be stored at -20°C in a dry, dark, and well-sealed container. To maintain biological activity, avoid repeated freeze-thaw cycles.
No, this product is strictly designated for research use only. It is not a clinical therapeutic agent and should not be administered to humans.
Purity is verified using Reverse-Phase High-Performance Liquid Chromatography (RP-HPLC) and Mass Spectrometry (MS) to ensure it meets the ≥99.0% standard.
Yes, we can customize packaging according to specific customer needs to ensure product stability and compliance with local transportation regulations.
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