D-alpha-Tocotrienol CAS NO.58864-81-6
TECHNICAL SPECIFICATIONS
| Item | Specification |
|---|---|
| Product Name | D-alpha-Tocotrienol |
| CAS NO. | 58864-81-6 |
| Appearance | Off-white to pale yellow oily liquid or powder |
| Molecular Formula | C₂₉H₄₄O₂ |
| Molecular Weight | 424.66 g/mol |
| Purity (RP-HPLC) | ≥98.0% |
| Solubility | Soluble in DMSO (~10 mg/mL), DMF (~10 mg/mL), chloroform, and methanol; sparingly soluble in aqueous buffers |
| Endotoxin | < 1.0 EU/mg |
| Biological Activity | Potent antioxidant; inhibits lipid peroxidation, exhibits neuroprotective, anti-inflammatory, and cholesterol-lowering properties; suppresses HMG-CoA reductase activity |
| Storage Conditions | Store at -20°C, protected from light and moisture; avoid repeated freeze-thaw cycles |
| Stock Location | Stock in USA |
| MOQ | 1g |
1.MECHANISM OF ACTION
- Superior Antioxidant & Anti-inflammatory Activity: Due to its unsaturated side chain, it distributes more uniformly within cell membranes, providing more efficient protection against lipid peroxidation. It modulates key inflammatory pathways, such as suppressing NF-κB and STAT3 signaling.
- HMG-CoA Reductase Regulation (Cholesterol Synthesis): It uniquely induces the ubiquitination and degradation of HMG-CoA reductase, the rate-limiting enzyme in cholesterol biosynthesis, leading to a reduction in serum cholesterol levels without the side effects of statin drugs.
- Induction of Apoptosis in Cancer Cells: It exhibits potent anti-cancer activity by inducing cancer cell apoptosis via both intrinsic and extrinsic pathways, and by inhibiting the PI3K/Akt, NF-κB, and Wnt/β-catenin oncogenic signaling cascades.
- Neuroprotection: It is highly neuroprotective at nanomolar concentrations, primarily by suppressing the activity of 12-lipoxygenase (12-LOX) and attenuating glutamate-induced neurodegeneration, mechanisms not shared by alpha-tocopherol.
2.PRODUCT INDICATIONS
- Cardiovascular Health: Dietary supplements for cholesterol management, atherosclerosis prevention, and overall vascular health.
- Neuroprotection: Formulations targeting brain health, stroke prevention, and neurodegenerative conditions (Alzheimer's, Parkinson's).
- Oncology Support: As an adjuvant in cancer prevention and therapy research, and in supplements for cellular health.
- Cosmetic & Skincare: High-performance active in anti-aging, antioxidant, and UV-protective serums and creams due to its superior skin penetration and protection.
- General Health & Wellness: Broad-spectrum antioxidant and anti-inflammatory supplements.
3.CLINICAL EFFICACY OF PRODUCT
- Cholesterol & Cardiovascular Health: Human trials show that mixed tocotrienol supplementation can significantly lower total and LDL ("bad") cholesterol, reduce arterial stiffness, and regress carotid artery atherosclerosis.
- Neuroprotection: Clinical studies indicate that tocotrienol-rich supplementation can reduce white matter lesions in the brain and improve biomarkers of vascular cognitive impairment.
- Anti-cancer Potential: Emerging clinical data, especially on delta- and gamma-tocotrienols, show promise in combination therapy for various cancers, with D-alpha-tocotrienol contributing to the overall bioactive pool.
- Safety: Natural tocotrienols are well-tolerated and do not exhibit the pro-coagulant effects associated with high-dose alpha-tocopherol.
4.Certificate
GlobalTech Co., Ltd. is committed to providing high-purity biotechnological peptide products, adhering strictly to quality standards and obtaining internationally recognized certifications.
Our production partners all employ GMP-compliant production systems and possess standardized quality control processes covering raw material procurement, synthesis, purification, testing, packaging, and storage. Each batch of product comes with complete documentation, including a Certificate of Analysis (COA), HPLC purity report, mass spectrometry (MS) chromatograms, and third-party testing reports available upon request.
We prioritize:
1.A rigorous quality management system
2.Batch traceability and stability data
3.Professional laboratory testing and validation
4.Compliance with international trade standards
Our commitment to quality, transparency, and regulatory compliance ensures the provision of reliable, stable, and research-grade peptide products to our global partners.
5.DELIVERY & SHIPPING
We specialize in global logistics for various cosmetic peptides. Your order will be handled with the utmost care, ensuring safe, reliable, and intact delivery.
Professional and Secure Packaging
Each bottle of peptide is protected with a special packaging solution to ensure stability and integrity during transportation.
We can also customize packaging according to customer needs.
Shipping Methods
Main Method: International Air Freight
We primarily use DHL, FedEx, UPS, and TNT because of their global reliability, speed, and advanced tracking systems. Air freight ensures the fastest transit time and minimizes the impact of environmental factors on the product.
Global Technology Co., Ltd. is a modern and advanced enterprise specializing in the production and export of active pharmaceutical ingredients (APIs), peptides, and plant extracts. The company invests in and collaborates closely with domestic manufacturers holding GMP, DMF, and FDA certifications, as well as laboratories at renowned universities, to meet diverse customer needs ranging from gram-level to ton-level. This enables Dejurui Pharmaceutical to provide customers with more flexible and convenient access to cost-effective, high-quality products and superior services.
We focus on the research and development and supply of high-quality chemical products, strictly adhering to international standards and quality systems. Our products are stable in performance and reliable in purity, widely used in industrial manufacturing, scientific research, and the fine chemical industry. We provide solid support at every stage with a professional and responsible attitude.
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