Name: D-Lys16-ACTH (1-24) CAS 494750-52-6 - Premium Peptide Supply
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[D-Lys16]-ACTH（1-24）CAS NO.494750-52-6

[D-Lys16]-ACTH (1-24) is a synthetic peptide analog of adrenocorticotropic hormone (ACTH) featuring a D-lysine substitution at position 16. This structural modification enhances its stability against enzymatic degradation compared to the native hormone, making it a valuable tool for research into the hypothalamic-pituitary-adrenal (HPA) axis. It is widely used in neuroendocrinology and pharmacology studies to investigate adrenal function and hormone regulation.

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TECHNICAL SPECIFICATIONS

Item	Specification
Product Name	[D-Lys16]-ACTH（1-24）
CAS NO.	494750-52-6
Appearance	White to off-white lyophilized powder
Molecular Formula	C₁₃₆H₂₁₀N₄₀O₃₁S
Molecular Weight	3017.4 g/mol
Purity (RP-HPLC)	≥ 95.0%
Solubility	Soluble in water, acidic aqueous solutions; insoluble in non-polar solvents
Endotoxin	≤1 EU/mg (LAL test)
Biological Activity	Potent agonist of melanocortin 2 receptor (MC2R), stimulates adrenal steroidogenesis
Storage Conditions	Store at -20°C, protected from light and moisture; avoid repeated freeze-thaw cycles
Stock Location	Stock in USA
MOQ	1g

1.MECHANISM OF ACTION

The peptide acts as a potent agonist of melanocortin 2 receptors (MC2R) located on adrenal cortex cells. Upon binding, it activates adenylate cyclase, leading to an increase in intracellular cAMP levels. This signaling cascade stimulates the synthesis and secretion of corticosteroids, primarily cortisol, from the adrenal glands. The D-amino acid substitution helps maintain biological activity while potentially altering receptor interaction kinetics for specialized research applications.

2.PRODUCT INDICATIONS

This product is indicated for scientific research purposes only, including studies on adrenal insufficiency, stress response mechanisms, and HPA axis dysregulation. It serves as a critical reagent in the development of diagnostic agents, such as contrast media for imaging, and is utilized in structure-activity relationship (SAR) studies to design novel peptide therapeutics targeting melanocortin receptors.

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3.CLINICAL EFFICACY OF PRODUCT

In preclinical research settings, [D-Lys16]-ACTH (1-24) has demonstrated efficacy in stimulating adrenal steroidogenesis, effectively elevating plasma cortisol levels in animal models. Its enhanced metabolic stability allows for prolonged in vivo effects, supporting its use as a reliable standard in adrenal function testing and as a lead compound in the development of long-acting ACTH analogs for investigative use.

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4.Certificate

GlobalTech Co., Ltd. is committed to providing high-purity biotechnological peptide products, adhering strictly to quality standards and obtaining internationally recognized certifications.

Our production partners all employ GMP-compliant production systems and possess standardized quality control processes covering raw material procurement, synthesis, purification, testing, packaging, and storage. Each batch of product comes with complete documentation, including a Certificate of Analysis (COA), HPLC purity report, mass spectrometry (MS) chromatograms, and third-party testing reports available upon request.

We prioritize:

1.A rigorous quality management system

2.Batch traceability and stability data

3.Professional laboratory testing and validation

4.Compliance with international trade standards

Our commitment to quality, transparency, and regulatory compliance ensures the provision of reliable, stable, and research-grade peptide products to our global partners.

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5.DELIVERY & SHIPPING

We specialize in global logistics for various cosmetic peptides. Your order will be handled with the utmost care, ensuring safe, reliable, and intact delivery.

Professional and Secure Packaging

Each bottle of peptide is protected with a special packaging solution to ensure stability and integrity during transportation.

We can also customize packaging according to customer needs.

Shipping Methods

Main Method: International Air Freight

We primarily use DHL, FedEx, UPS, and TNT because of their global reliability, speed, and advanced tracking systems. Air freight ensures the fastest transit time and minimizes the impact of environmental factors on the product.

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Global Technology Co., Ltd. is a modern and advanced enterprise specializing in the production and export of active pharmaceutical ingredients (APIs), peptides, and plant extracts. The company invests in and collaborates closely with domestic manufacturers holding GMP, DMF, and FDA certifications, as well as laboratories at renowned universities, to meet diverse customer needs ranging from gram-level to ton-level. This enables Dejurui Pharmaceutical to provide customers with more flexible and convenient access to cost-effective, high-quality products and superior services.

We focus on the research and development and supply of high-quality chemical products, strictly adhering to international standards and quality systems. Our products are stable in performance and reliable in purity, widely used in industrial manufacturing, scientific research, and the fine chemical industry. We provide solid support at every stage with a professional and responsible attitude.

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