Degarelix Acetate CAS NO.214766-78-6
TECHNICAL SPECIFICATIONS
| Item | Specification |
|---|---|
| Product Name | Degarelix Acetate |
| CAS NO. | 214766-78-6 |
| Appearance | White to off-white lyophilized powder |
| Molecular Formula | C82H103C1N18O16 |
| Molecular Weight | 1632.28 g/mol |
| Purity (RP-HPLC) | ≥ 98.0% |
| Solubility | Soluble in water for injection; reconstitutes in sterile water or saline |
| Endotoxin | ≤1 EU/mg |
| Biological Activity | Potent GnRH receptor antagonist; induces rapid and sustained testosterone suppression |
| Storage Conditions | Store at 2–8°C; protect from light; do not freeze |
| Stock Location | Stock in USA |
| MOQ | 1g |
1.MECHANISM OF ACTION
Degarelix functions as a selective gonadotropin-releasing hormone (GnRH) antagonist that competitively and reversibly binds to pituitary GnRH receptors. This action blocks the binding of endogenous GnRH, leading to an immediate reduction in the release of luteinizing hormone (LH) and follicle-stimulating hormone (FSH). By inhibiting this signaling pathway, the drug rapidly suppresses testicular testosterone production to castrate levels (typically <0.5 ng/mL) within days of administration. Unlike GnRH agonists, which initially stimulate hormone release before suppressing it, degarelix provides direct receptor blockade, avoiding the potentially harmful testosterone flare that can exacerbate cancer symptoms or pose risks in metastatic settings.
2.PRODUCT INDICATIONS
Clinical studies have demonstrated that degarelix achieves castrate levels of testosterone in approximately 97% of patients by day 3 of treatment and maintains this suppression in over 98% of subjects through 12 months of therapy. In pivotal Phase III trials, the drug showed non-inferiority to leuprolide in testosterone control while providing a superior profile in avoiding PSA progression, particularly in high-risk subgroups. The rapid onset of action is beneficial for patients with significant disease burden, and pooled analyses suggest a potential association with a lower incidence of cardiovascular events compared to some GnRH agonists, alongside effective long-term management of prostate cancer progression.
3.CLINICAL EFFICACY OF PRODUCT
4.Certificate
GlobalTech Co., Ltd. is committed to providing high-purity biotechnological peptide products, adhering strictly to quality standards and obtaining internationally recognized certifications.
Our production partners all employ GMP-compliant production systems and possess standardized quality control processes covering raw material procurement, synthesis, purification, testing, packaging, and storage. Each batch of product comes with complete documentation, including a Certificate of Analysis (COA), HPLC purity report, mass spectrometry (MS) chromatograms, and third-party testing reports available upon request.
We prioritize:
1.A rigorous quality management system
2.Batch traceability and stability data
3.Professional laboratory testing and validation
4.Compliance with international trade standards
Our commitment to quality, transparency, and regulatory compliance ensures the provision of reliable, stable, and research-grade peptide products to our global partners.
5.DELIVERY & SHIPPING
We specialize in global logistics for various cosmetic peptides. Your order will be handled with the utmost care, ensuring safe, reliable, and intact delivery.
Professional and Secure Packaging
Each bottle of peptide is protected with a special packaging solution to ensure stability and integrity during transportation.
We can also customize packaging according to customer needs.
Shipping Methods
Main Method: International Air Freight
We primarily use DHL, FedEx, UPS, and TNT because of their global reliability, speed, and advanced tracking systems. Air freight ensures the fastest transit time and minimizes the impact of environmental factors on the product.
Global Technology Co., Ltd. is a modern and advanced enterprise specializing in the production and export of active pharmaceutical ingredients (APIs), peptides, and plant extracts. The company invests in and collaborates closely with domestic manufacturers holding GMP, DMF, and FDA certifications, as well as laboratories at renowned universities, to meet diverse customer needs ranging from gram-level to ton-level. This enables Dejurui Pharmaceutical to provide customers with more flexible and convenient access to cost-effective, high-quality products and superior services.
We focus on the research and development and supply of high-quality chemical products, strictly adhering to international standards and quality systems. Our products are stable in performance and reliable in purity, widely used in industrial manufacturing, scientific research, and the fine chemical industry. We provide solid support at every stage with a professional and responsible attitude.
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