Dermaseptin CAS NO.136212-91-4

Dermaseptin CAS NO.136212-91-4

Dermaseptin CAS NO.136212-91-4

Dermaseptin CAS NO.136212-91-4

Dermaseptin CAS NO.136212-91-4

Dermaseptin is a naturally derived cationic antimicrobial peptide (AMP) sourced from frog skin secretions, renowned for its potent broad-spectrum activity against bacteria, fungi, and viruses. It serves as a high-purity research-grade compound for studying novel anti-infective mechanisms, particularly in addressing antibiotic-resistant strains and biofilm-associated infections, while also exhibiting promising low cytotoxicity profiles in preclinical models.



TECHNICAL SPECIFICATIONS


Item
Specification
Product Name
Dermaseptin
CAS NO.
136212-91-4
Appearance
White to off-white crystalline powder
Molecular Formula
C₁₅₂H₂₅₇N₄₃O₄₄S₂
Molecular Weight
3455.52g/mol
Purity (RP-HPLC)
≥ 98.0%
Solubility

Soluble in water and acidic aqueous buffers; partially soluble in methanol; insoluble in nonpolar organic solvents

Endotoxin< 0.5 EU/mg (for pharmaceutical-grade material)
Biological Activity
Potent antimicrobial peptide effective against Gram-positive and Gram-negative bacteria, fungi, and some viruses; exhibits selective cytotoxicity toward cancer cells while sparing normal cells
Storage Conditions
Store at 2–8°C in a dry, dark place; protect from moisture and prolonged exposure to light
Stock Location
Stock in USA
MOQ
1g


1.MECHANISM OF ACTION

The peptide primarily functions via a "carpet-like" mechanism, where its cationic and amphipathic alpha-helical structure selectively targets and disrupts the anionic membranes of microbial pathogens. This interaction increases membrane permeability, leading to rapid cell lysis and death, without significant damage to mammalian cells, thereby providing a physical barrier-breaking action against biofilms and persistent infections.

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2.PRODUCT INDICATIONS

Dermaseptin is indicated for preclinical research in topical antimicrobial formulations, wound healing applications, and as a potential adjuvant to conventional antibiotics. It is particularly relevant for studies focusing on multidrug-resistant organisms (like MRSA), chronic wound biofilms, and as a template for developing next-generation anti-infective agents in dermatology and antimicrobial coating technologies.

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3.CLINICAL EFFICACY OF PRODUCT

In experimental models, Dermaseptin demonstrates significant efficacy in eradicating established biofilms and accelerating the healing of infected wounds, with studies showing potent bactericidal effects at low micromolar concentrations. It has shown synergistic effects with traditional antibiotics, reducing bacterial load and inflammation in skin infection models, though human clinical data remains in early stages.

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4.Certificate

GlobalTech Co., Ltd. is committed to providing high-purity biotechnological peptide products, adhering strictly to quality standards and obtaining internationally recognized certifications.


Our production partners all employ GMP-compliant production systems and possess standardized quality control processes covering raw material procurement, synthesis, purification, testing, packaging, and storage. Each batch of product comes with complete documentation, including a Certificate of Analysis (COA), HPLC purity report, mass spectrometry (MS) chromatograms, and third-party testing reports available upon request.


We prioritize:

1.A rigorous quality management system

2.Batch traceability and stability data

3.Professional laboratory testing and validation

4.Compliance with international trade standards


Our commitment to quality, transparency, and regulatory compliance ensures the provision of reliable, stable, and research-grade peptide products to our global partners.

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5.DELIVERY & SHIPPING

We specialize in global logistics for various cosmetic peptides. Your order will be handled with the utmost care, ensuring safe, reliable, and intact delivery.

Professional and Secure Packaging

Each bottle of peptide is protected with a special packaging solution to ensure stability and integrity during transportation.

We can also customize packaging according to customer needs.

Shipping Methods 

Main Method: International Air Freight

We primarily use DHL, FedEx, UPS, and TNT because of their global reliability, speed, and advanced tracking systems. Air freight ensures the fastest transit time and minimizes the impact of environmental factors on the product.

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Global Technology Co., Ltd. is a modern and advanced enterprise specializing in the production and export of active pharmaceutical ingredients (APIs), peptides, and plant extracts. The company invests in and collaborates closely with domestic manufacturers holding GMP, DMF, and FDA certifications, as well as laboratories at renowned universities, to meet diverse customer needs ranging from gram-level to ton-level. This enables Dejurui Pharmaceutical to provide customers with more flexible and convenient access to cost-effective, high-quality products and superior services.


We focus on the research and development and supply of high-quality chemical products, strictly adhering to international standards and quality systems. Our products are stable in performance and reliable in purity, widely used in industrial manufacturing, scientific research, and the fine chemical industry. We provide solid support at every stage with a professional and responsible attitude.


Hot Tags: Dermaseptin #AntimicrobialPeptide #AMPs #AntiBiofilm #WoundHealing #MRSA #FrogSkinPeptide #BroadSpectrumAntimicrobial


If you have any product requirements, please send an email to:sales@huanqiukeji9.com;whatsapp:85244219157

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