![[Des-Asp187,Met186]-Melanocyte Protein PMEL 17 (185-193) (human, bovine, mouse) CAS NO.255710-51-1](https://images.cnmqh.com/images/a10134/4cfa347547704c59f1a2b86f155b9580-20260129064035.webp "[Des-Asp187,Met186]-Melanocyte Protein PMEL 17 (185-193) (human, bovine, mouse) CAS NO.255710-51-1")
[Des-Asp187,Met186]-Melanocyte Protein PMEL 17 (185-193) (human, bovine, mouse) CAS NO.255710-51-1
[Des-Asp187,Met186]-Melanocyte Protein PMEL 17 (185-193) (human, bovine, mouse) CAS NO.255710-51-1
TECHNICAL SPECIFICATIONS
| Item | Specification |
|---|---|
| Product Name | [Des-Asp187,Met186]-Melanocyte Protein PMEL 17 (185-193) (human, bovine, mouse) |
| CAS NO. | 255710-51-1 |
| Appearance | White to off-white lyophilized powder |
| Molecular Formula | C43H69N9O11S |
| Molecular Weight | 920.15g/mol |
| Purity (RP-HPLC) | ≥ 95.0% |
| Solubility | Soluble in water, physiological saline, or PBS buffer. It is recommended to prepare a stock solution of 1–10 mg/mL using sterile water or PBS, aliquot, and store at ≤-20°C. |
| Endotoxin | < 1.0 EU/mg |
| Biological Activity | This product is an immunodominant CTL epitope modified from the PMEL17/gp100 protein, which can be used for T cell immune recognition studies and tumor immunology-related experiments. Its activity needs to be verified through in vitro T cell stimulation experiments. |
| Storage Conditions | Lyophilized powder: Store at -20°C or lower in a dry environment protected from light; it is stable for a long time. Reconstituted solution: After aliquoting, store frozen at ≤-20°C, avoiding repeated freeze-thaw cycles. |
| Stock Location | Stock in USA |
| MOQ | 1g |
1.MECHANISM OF ACTION
The mechanism of action involves presentation of this modified peptide epitope by major histocompatibility complex (MHC) class I molecules, particularly HLA-A*0201, on the surface of antigen-presenting cells. When presented, the peptide is recognized by specific T cell receptors (TCRs) on CD8+ cytotoxic T lymphocytes, leading to T cell activation, proliferation, and the generation of antigen-specific immune responses. The specific amino acid deletions (Des-Asp187, Met186) in this analog are designed to enhance peptide stability, improve MHC binding affinity, and potentially increase immunogenicity compared to the native epitope, thereby facilitating more robust T cell activation in experimental systems for studying antigen-specific immune recognition and T cell-mediated cytotoxicity.
2.PRODUCT INDICATIONS
This PMEL17/gp100 peptide analog is indicated for research use only in preclinical studies investigating tumor immunology, melanoma antigen recognition, T cell activation mechanisms, and cancer immunotherapy development. It serves as a specific antigenic peptide for in vitro T cell stimulation assays, ELISPOT assays, intracellular cytokine staining, and the generation of antigen-specific T cell lines or clones. The product is also used in studies of antigen presentation, MHC-peptide binding assays, and the evaluation of T cell receptor recognition in the context of melanoma and other cancers expressing PMEL17/gp100. It is not intended for diagnostic, therapeutic, or clinical applications in humans or animals, and should be handled by trained research personnel in appropriate laboratory settings.
3.CLINICAL EFFICACY OF PRODUCT
As a research reagent, [Des-Asp187,Met186]-Melanocyte Protein PMEL 17 (185-193) (human, bovine, mouse) does not have established clinical efficacy for therapeutic use in human patients. While this peptide analog and related PMEL17/gp100 epitopes have been studied in preclinical models and some early-phase clinical trials of cancer vaccines and adoptive T cell therapies, the product itself has not undergone clinical development or received regulatory approval for any medical indication. Research using this peptide has contributed to the understanding of tumor antigen recognition and the development of immunotherapeutic strategies, but the product remains an investigational research tool without proven clinical efficacy or safety profile for human use.
4.DELIVERY & SHIPPING
We specialize in global logistics for various cosmetic peptides. Your order will be handled with the utmost care, ensuring safe, reliable, and intact delivery.
Professional and Secure Packaging
Each bottle of peptide is protected with a special packaging solution to ensure stability and integrity during transportation.
We can also customize packaging according to customer needs.
Shipping Methods
Main Method: International Air Freight
We primarily use DHL, FedEx, UPS, and TNT because of their global reliability, speed, and advanced tracking systems. Air freight ensures the fastest transit time and minimizes the impact of environmental factors on the product.
May 25, 26
Premium API Oxandrolone Ucinky Manufacturing
Premium API Oxandrolone Ucinky Manufacturing Leading global supplier of high-purity chemical raw materials for pharmaceutical grade Oxandrolone Ucinky, combining precision engineering with industrial scale. 5000 kg Annual Output 120 Countries Served 5 Days Sample Lead Time 99.7 On-Time Delivery Industrial Precision Pure Chemical Synthesis Engineering the future of pharmaceutical intermediates with unmatched stability. Our facility stands as a global leader in the oxandrolone ucinky sector, utilizing CRYOGENIC CRYSTALLIZATION and advanced chromatography to ensure an assay purity exceeding 99.8. We integrate a fully automated closed-loop system that eliminates human error and contamination.
May 22, 26
Clinical Benefits and Applications of Oxandrolone Therapy
Oxandrolone therapy represents a sophisticated intersection of endocrine science and regenerative medicine, primarily utilized to address muscle wasting and metabolic dysfunction. In the global pharmaceutical landscape, this specific approach to androgen therapy is valued for its unique ability to promote protein synthesis while exhibiting a lower androgenic profile compared to traditional steroids, making it a critical tool for patients recovering from severe trauma or chronic illness. From a clinical perspective, understanding the nuances of oxandrolone therapy is essential for optimizing patient outcomes in weight gain and tissue repair.
May 20, 26
Clinical Benefits and Production of Oxandrolone Steroid
The global pharmaceutical landscape has seen a significant rise in the demand for highly specialized anabolic agents, among which the oxandrolone steroid stands out due to its unique chemical profile and therapeutic versatility. As a modified version of dihydrotestosterone, this compound provides a potent means of addressing muscle wasting and metabolic deficits, making it a critical asset in both clinical rehabilitation and advanced physiological research. Understanding the nuances of this synthetic compound is essential for healthcare providers and researchers alike, as it balances efficacy with a relatively lower androgenic profile compared to other steroids.
