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[Des-Gly77,His78] Myelin Basic Protein (68-84), bovine CAS NO.98474-59-0
TECHNICAL SPECIFICATIONS
| Item | Specification |
|---|---|
| Product Name | [Des-Gly77,His78] Myelin Basic Protein (68-84), bovine |
| CAS NO. | 98474-59-0 |
| Appearance | White to off-white lyophilized powder |
| Molecular Formula | C73H115N23O26 |
| Amino Acid Sequence | H-Gly-Ser-Leu-Pro-Gln-Lys-Ser-His-Tyr-Gly-Ser-Leu-Pro-Gln-Lys-OH (corresponding to bovine MBP residues 68-84, with deletion of Gly77 and His78) |
| Molecular Weight | 1730.87g/mol |
| Purity (RP-HPLC) | ≥95.0% (typical for custom research peptides) |
| Solubility | Soluble in water, PBS, or dilute acetic acid solution (0.1-1% acetic acid recommended) |
| Endotoxin | < 1.0 EU/mg |
| Biological Activity | Modified MBP epitope; used in autoimmune research (e.g., experimental autoimmune encephalomyelitis/EAE models), T-cell epitope mapping, and multiple sclerosis studies. |
| Storage Conditions | Store at –20°C (lyophilized) or –80°C (solution). Protect from light and repeated freeze‑thaw cycles. |
| Stock Location | Stock in USA |
| MOQ | 1mg |
1.MECHANISM OF ACTION
This peptide acts as a specific antigenic epitope that can be presented by major histocompatibility complex (MHC) molecules to activate autoreactive T-cells. In experimental models, it helps simulate the immune-mediated attack on myelin sheaths, providing a tool to study the pathogenesis of demyelinating diseases such as multiple sclerosis.
2.PRODUCT INDICATIONS
[Des-Gly77,His78] Myelin Basic Protein (68-84), bovine is primarily used in preclinical research to model autoimmune encephalomyelitis (EAE), investigate T-cell responses, and evaluate potential therapies for multiple sclerosis and other myelin-related disorders. It is also applied in epitope mapping and immunological assay development.
3.CLINICAL EFFICACY OF PRODUCT
As a research tool, this peptide is not intended for direct clinical use. However, it has proven effective in inducing EAE in animal models, enabling the study of disease mechanisms and the screening of immunomodulatory or neuroprotective compounds, thereby supporting translational research aimed at developing new treatments for autoimmune demyelinating conditions.
4.DELIVERY & SHIPPING
We specialize in global logistics for various cosmetic peptides. Your order will be handled with the utmost care, ensuring safe, reliable, and intact delivery.
Professional and Secure Packaging
Each bottle of peptide is protected with a special packaging solution to ensure stability and integrity during transportation.
We can also customize packaging according to customer needs.
Shipping Methods
Main Method: International Air Freight
We primarily use DHL, FedEx, UPS, and TNT because of their global reliability, speed, and advanced tracking systems. Air freight ensures the fastest transit time and minimizes the impact of environmental factors on the product.
