Name: Des-octanoyl Ghrelin Human Peptide CAS 313951-59-6 for Research
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[Des-octanoyl]-Ghrelin, human CAS NO.313951-59-6

[Des-octanoyl]-Ghrelin, human (CAS NO. 313951-59-6) is a 28-amino-acid peptide with the molecular formula C₁₄₁H₂₃₅N₄₇O₄₁ and molecular weight 3244.74 g/mol. As a deacylated analog of human ghrelin, it lacks the critical octanoyl group at Ser³, making it a key tool for studying acylation-dependent ghrelin functions, GHS-R1a receptor interactions, and metabolic regulation.

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TECHNICAL SPECIFICATIONS

Item	Specification
Product Name	[Des-octanoyl]-Ghrelin, human
CAS NO.	313951-59-6
Appearance	White to off-white lyophilized powder
Molecular Formula	C₁₄₁H₂₃₅N₄₇O₄₁
Molecular Weight	3244.74 g/mol
Purity (RP-HPLC)	≥ 98.0%
Solubility	Freely soluble in deionized water (pH 4.0–7.0) or 0.1 M acetic acid; partially soluble in DMSO (≤2 mg/mL) to avoid precipitation.
Endotoxin	< 1.0 EU/mg
Biological Activity	Des-octanoyl (deacylated) analog of human ghrelin, lacking the critical octanoyl group at Ser³. Retains partial binding to growth hormone secretagogue receptor 1a (GHS-R1a; human, Ki: 10–100 nM) but with reduced affinity compared to native ghrelin. Does not stimulate growth hormone (GH) release or appetite; used to study receptor-ligand interactions, acylation-dependent signaling, and ghrelin metabolism.
Storage Conditions	Store at -20°C in a tightly sealed, light-protected container; avoid moisture and repeated freeze-thaw cycles.
Stock Location	Stock in USA
MOQ	1g

1.MECHANISM OF ACTION

GHS-R1a Binding (Low Affinity): Binds to the growth hormone secretagogue receptor 1a (GHS-R1a) with reduced affinity (human, Ki: 10–100 nM) compared to native ghrelin (Ki: 0.1–1 nM) due to the absence of the octanoyl group, which is critical for high-affinity receptor activation.

Receptor Interaction Studies: Serves as a negative control or competitive inhibitor in GHS-R1a binding assays, helping to dissect the role of acylation in receptor-ligand interactions.

Metabolic Role Investigation: Does not stimulate growth hormone (GH) release or appetite, allowing researchers to isolate the effects of acylation on ghrelin’s metabolic functions.

2.PRODUCT INDICATIONS

Ghrelin Receptor Research: Studying the structural basis of GHS-R1a activation and the role of acylation in receptor binding.

Metabolic Studies: Investigating the differential effects of acylated vs. deacylated ghrelin on energy balance, adipogenesis, and glucose metabolism.

Drug Development: Screening GHS-R1a modulators (agonists/antagonists) and validating their mechanism of action using a deacylated control.

3.CLINICAL EFFICACY OF PRODUCT

Preclinical Validation:

Binds GHS-R1a with 10–100x lower affinity than native ghrelin (radioreceptor assays).

Fails to stimulate GH release from human pituitary cells (vs. 3–5x increase with native ghrelin).

Does not increase food intake in rodent models (vs. 40–60% increase with native ghrelin).

Therapeutic Relevance: Serves as a critical control in preclinical studies of GHS-R1a-targeted therapies, helping to validate the importance of acylation in drug efficacy.

4.DELIVERY & SHIPPING

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Professional and Secure Packaging
Each bottle of peptide is protected with a special packaging solution to ensure stability and integrity during transportation.
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Shipping Methods
Main Method: International Air Freight

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