TECHNICAL SPECIFICATIONS
Item
| Specification
|
|---|
Product Name
| Dynorphin A (1-13) Acetate
|
CAS NO.
| 72957-38-1 |
Appearance
| White to off-white lyophilized powder
|
Molecular Formula
| C75H126N24O15
|
Molecular Weight
| 1603.98 g/mol |
Purity (RP-HPLC)
| ≥ 95.0% |
Solubility
| Soluble in water, dilute acetic acid, and PBS buffer; may require gentle vortexing |
| Endotoxin | < 1.0 EU/mg
|
Biological Activity
| Endogenous opioid peptide; selective κ-opioid receptor agonist with analgesic and neuroregulatory effects.
|
Storage Conditions
| Store at -20°C, protected from light and moisture. After reconstitution, aliquot and store at -20°C.
|
Stock Location
| Stock in USA
|
MOQ
| 1g |
1.MECHANISM OF ACTION
Dynorphin A (1-13) Acetate functions as a selective agonist for kappa-opioid receptors (KOR) in the central and peripheral nervous systems. Upon binding, it activates Gi/o protein-coupled signaling pathways, leading to inhibition of adenylate cyclase, reduced cAMP production, and modulation of ion channel activity. This action results in hyperpolarization of neurons, decreased neurotransmitter release (particularly dopamine in the mesolimbic pathway), and modulation of pain perception, stress responses, and emotional processing.
2.PRODUCT INDICATIONS
Neuroscience Research: Investigation of kappa-opioid receptor function, signaling pathways, and neural circuitry
Pain Mechanism Studies: Research on endogenous pain modulation and analgesic systems
Psychopharmacology: Studies of stress responses, addiction mechanisms, and mood regulation
Neuropsychiatric Research: Investigation of depression, anxiety, and reward processing disorders
Drug Discovery: Screening and development of novel kappa-opioid receptor-targeted therapeutics
3.CLINICAL EFFICACY OF PRODUCT
Receptor Specificity: High selectivity for kappa-opioid receptors with minimal cross-reactivity to mu- and delta-opioid receptors
Biological Activity: Verified analgesic and anti-stress effects in validated animal models
Research Reliability: Consistent performance in receptor binding assays and functional studies
Scientific Validation: Supported by extensive literature on dynorphin physiology and opioid pharmacology
Quality Assurance: ≥95% HPLC purity with comprehensive analytical characterization
Technical Support: Available data on receptor binding constants and functional activity profiles
4.DELIVERY & SHIPPING
We specialize in global logistics for various cosmetic peptides. Your order will be handled with the utmost care, ensuring safe, reliable, and intact delivery.
Professional and Secure Packaging
Each bottle of peptide is protected with a special packaging solution to ensure stability and integrity during transportation.
We can also customize packaging according to customer needs.
Shipping Methods
Main Method: International Air Freight
We primarily use DHL, FedEx, UPS, and TNT because of their global reliability, speed, and advanced tracking systems. Air freight ensures the fastest transit time and minimizes the impact of environmental factors on the product.
