Name: High-Purity Dynorphin A (1-6), Porcine CAS 75106-70-6
Availability: InStock
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Dynorphin A (1-6), porcine CAS NO.75106-70-6

Dynorphin A (1-6), porcine is a bioactive N-terminal hexapeptide fragment (Tyr-Gly-Gly-Phe-Leu-Arg) derived from the endogenous precursor prodynorphin. It retains the core opioid motif and serves as a potent ligand for studying kappa opioid receptor (KOR) signaling pathways in neurological research. This synthetic peptide is widely utilized in structure-activity relationship (SAR) studies to delineate the minimal sequence required for receptor binding and activation, providing a stable and reliable tool for in vitro and in vivo pharmacological experiments.

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TECHNICAL SPECIFICATIONS

Item	Specification
Product Name	Dynorphin A (1-6), porcine
CAS NO.	75106-70-6
Appearance	White to off-white lyophilized powder
Molecular Formula	C₃₄H₄₉N₉O₈
Molecular Weight	727.8g/mol
Purity (RP-HPLC)	≥95%
Solubility	Soluble in water, dilute acetic acid, or 1M NaOH
Endotoxin	≤1 EU/mg
Biological Activity	Potent endogenous kappa-opioid receptor (KOR) agonist
Storage Conditions	Store at -20°C, protected from moisture and light
Stock Location	Stock in USA
MOQ	1g

1.MECHANISM OF ACTION

This peptide functions as a selective agonist for the kappa-opioid receptor (KOR), primarily activating Gi/o protein-coupled signaling cascades. Upon binding, it inhibits adenylate cyclase activity, leading to reduced intracellular cAMP levels and modulation of voltage-gated calcium and potassium channels. This results in neuronal hyperpolarization and suppression of neurotransmitter release, which underlies its observed effects on pain transmission and neuroregulation in experimental models.

2.PRODUCT INDICATIONS

This product is indicated for preclinical research into metabolic syndrome and stress-related eating disorders, particularly for investigating the role of CRF-BP in obesity models. It is utilized in studies requiring precise modulation of free CRF levels to assess feeding behavior, thermogenesis, and insulin sensitivity, providing a unique approach for neuroscientists and endocrinologists exploring non-receptor-mediated CRF effects.

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3.CLINICAL EFFICACY OF PRODUCT

In experimental settings, this peptide demonstrates significant efficacy in producing KOR-mediated analgesia and modulating affective behaviors such as anxiety and dysphoria. Studies show it can influence feeding behavior and stress responses via central KOR activation. However, its efficacy profile is dose-dependent, with higher concentrations potentially leading to paradoxical hyperalgesia or motor effects, highlighting its utility in studying the complex biphasic nature of dynorphin signaling

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4.Certificate

GlobalTech Co., Ltd. is committed to providing high-purity biotechnological peptide products, adhering strictly to quality standards and obtaining internationally recognized certifications.

Our production partners all employ GMP-compliant production systems and possess standardized quality control processes covering raw material procurement, synthesis, purification, testing, packaging, and storage. Each batch of product comes with complete documentation, including a Certificate of Analysis (COA), HPLC purity report, mass spectrometry (MS) chromatograms, and third-party testing reports available upon request.

We prioritize:

1.A rigorous quality management system

2.Batch traceability and stability data

3.Professional laboratory testing and validation

4.Compliance with international trade standards

Our commitment to quality, transparency, and regulatory compliance ensures the provision of reliable, stable, and research-grade peptide products to our global partners.

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5.DELIVERY & SHIPPING

We specialize in global logistics for various cosmetic peptides. Your order will be handled with the utmost care, ensuring safe, reliable, and intact delivery.

Professional and Secure Packaging

Each bottle of peptide is protected with a special packaging solution to ensure stability and integrity during transportation.

We can also customize packaging according to customer needs.

Shipping Methods

Main Method: International Air Freight

We primarily use DHL, FedEx, UPS, and TNT because of their global reliability, speed, and advanced tracking systems. Air freight ensures the fastest transit time and minimizes the impact of environmental factors on the product.

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Global Technology Co., Ltd. is a modern and advanced enterprise specializing in the production and export of active pharmaceutical ingredients (APIs), peptides, and plant extracts. The company invests in and collaborates closely with domestic manufacturers holding GMP, DMF, and FDA certifications, as well as laboratories at renowned universities, to meet diverse customer needs ranging from gram-level to ton-level. This enables Dejurui Pharmaceutical to provide customers with more flexible and convenient access to cost-effective, high-quality products and superior services.

We focus on the research and development and supply of high-quality chemical products, strictly adhering to international standards and quality systems. Our products are stable in performance and reliable in purity, widely used in industrial manufacturing, scientific research, and the fine chemical industry. We provide solid support at every stage with a professional and responsible attitude.

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