Name: EGFR-Derived Peptide: Boost Cell Growth & Regeneration
Availability: InStock
Rating: 4.5 (89 reviews)

EGFR-derived peptide

EGFR-derived peptide is a synthetic peptide fragment derived from the Epidermal Growth Factor Receptor (EGFR) sequence. It is designed to mimic specific functional domains of EGFR, such as the ligand-binding or tyrosine kinase regions. This peptide is widely used in biochemical and cell-based assays to study EGFR signaling pathways, receptor-ligand interactions, and as a tool for developing targeted therapies. It is supplied as a high-purity, lyophilized powder for research use

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TECHNICAL SPECIFICATIONS

Item	Specification
Product Name	EGFR-derived Peptide
CAS NO.	/
Appearance	White to off-white lyophilized powder
Molecular Formula	C₄₆H₉₁N₂₁O₁₀
Molecular Weight	1098.35 g/mol
Purity (RP-HPLC)	≥ 95.0%
Solubility	Soluble in sterile water (≥1 mg/mL); soluble in aqueous buffers (PBS, Tris-HCl); sparingly soluble in organic solvents.
Endotoxin	< 1.0 EU/mg (Typical for research-grade peptides)
Biological Activity	Selective synthetic peptide substrate for Protein Kinase C (PKC). Used for in vitro measurement of PKC catalytic activity. Contains a consensus phosphorylation motif recognized by PKC, enabling sensitive detection of kinase activity via radiometric or fluorometric assays.
Storage Conditions	Lyophilized powder: Store at -20°C (desiccated) for 12–24 months. Reconstituted solution: Aliquot and store at -20°C; avoid repeated freeze-thaw cycles (stable for ≥1 month).
Stock Location	Stock in USA
MOQ	1g

1.MECHANISM OF ACTION

The peptide functions by competing with the native EGFR protein for binding to its ligands (e.g., EGF) or downstream signaling molecules. By occupying the binding sites, it inhibits the activation of the full-length receptor, thereby blocking downstream signaling cascades like the MAPK/ERK and PI3K/Akt pathways. This mechanism allows researchers to specifically disrupt EGFR-mediated signaling in experimental models to study its role in cell proliferation, survival, and differentiation.

2.PRODUCT INDICATIONS

This product is indicated for in vitro research applications, including:

Signal Transduction Studies: To investigate the role of EGFR in cancer biology and cell growth.
Drug Screening: As a control or competitor in assays testing EGFR inhibitors or antibodies.
Immunology: To study the immune response against EGFR in autoimmune or inflammatory conditions.
Biomarker Development: For developing diagnostic assays targeting specific EGFR epitopes.

3.CLINICAL EFFICACY OF PRODUCT

As a research reagent, this peptide is not used directly in clinical therapy. However, its utility lies in its role as a preclinical tool. It is used to validate the efficacy of anti-EGFR drugs (e.g., cetuximab, erlotinib) and to model EGFR-driven diseases like non-small cell lung cancer (NSCLC) and colorectal cancer. By inhibiting EGFR signaling in vitro, it demonstrates the potential therapeutic benefit of targeting this pathway, contributing to the development of more effective cancer treatments.

4.DELIVERY & SHIPPING

We specialize in global logistics for various cosmetic peptides. Your order will be handled with the utmost care, ensuring safe, reliable, and intact delivery.
Professional and Secure Packaging
Each bottle of peptide is protected with a special packaging solution to ensure stability and integrity during transportation.
We can also customize packaging according to customer needs.
Shipping Methods
Main Method: International Air Freight

We primarily use DHL, FedEx, UPS, and TNT because of their global reliability, speed, and advanced tracking systems. Air freight ensures the fastest transit time and minimizes the impact of environmental factors on the product.