Endomorphin-1 CAS NO.189388-22-5
Endomorphin-1 CAS NO.189388-22-5
TECHNICAL SPECIFICATIONS
| Item | Specification |
|---|---|
| Product Name | Endomorphin-1 (Em-1) |
| CAS NO. | 189388-22-5 |
| Appearance | White to off-white lyophilized powder |
| Molecular Formula | C₃₄H₃₈N₆O₅ |
| Molecular Weight | 610.71 g/mol |
| Purity (RP-HPLC) | ≥98% |
| Solubility | Soluble in sterile water (≥1 mg/mL, clear solution); soluble in DMSO (>30 mg/mL); soluble in aqueous buffers (PBS, Tris-HCl) |
| Endotoxin | < 1.0 EU/mg (Typical for research-grade peptides) |
| Biological Activity | Highly potent and selective agonist for the μ-opioid receptor (MOR). Exhibits high affinity (Ki < 1 nM) and selectivity over δ- and κ-opioid receptors. Acts as an endogenous analgesic, modulating pain perception, neurotransmitter release, and neuronal excitability in the central nervous system. |
| Storage Conditions | Lyophilized powder: Store at -20°C (desiccated) for 12–24 months. Reconstituted solution: Aliquot and store at -20°C; avoid repeated freeze-thaw cycles (stable for ≥1 month). |
| Stock Location | Stock in USA |
| MOQ | 1g |
1.MECHANISM OF ACTION
Endomorphin-1 exerts its effects by binding with high affinity and selectivity to μ-opioid receptors (MOR) in the central nervous system. Its mechanism involves:
- Receptor Activation: It acts as a full agonist at the μ-opioid receptor, leading to the activation of G-proteins.
- Signal Transduction: Upon binding, it inhibits adenylate cyclase activity, reducing intracellular cAMP levels.
- Ion Channel Modulation: It activates G-protein-coupled inwardly rectifying potassium (GIRK) channels, leading to hyperpolarization of neurons and inhibition of calcium channels, which reduces neurotransmitter release and pain signal transmission.
2.PRODUCT INDICATIONS
This product is indicated for scientific research applications, including:
- Pain Research: Investigation of analgesic mechanisms and the development of new pain therapies.
- Receptor Studies: Characterization of μ-opioid receptor function and selectivity.
- Neuropharmacology: Study of opioid signaling pathways and the physiological roles of endogenous opioids.
- Drug Development: Screening for novel analgesics with reduced side-effect profiles.
3.CLINICAL EFFICACY OF PRODUCT
While Endomorphin-1 is not currently approved for direct clinical use in humans, its preclinical profile is promising. Research indicates that it produces potent analgesia in animal models. Notably, studies suggest that at equianalgesic doses, it may cause less severe respiratory depression compared to traditional μ-agonists like morphine, indicating a potentially improved safety profile. Its high selectivity for μ-receptors also minimizes off-target effects associated with δ- and κ-opioid receptors, making it a valuable prototype for developing safer analgesic drugs.
4.DELIVERY & SHIPPING
We specialize in global logistics for various cosmetic peptides. Your order will be handled with the utmost care, ensuring safe, reliable, and intact delivery.
Professional and Secure Packaging
Each bottle of peptide is protected with a special packaging solution to ensure stability and integrity during transportation.
We can also customize packaging according to customer needs.
Shipping Methods
Main Method: International Air Freight
We primarily use DHL, FedEx, UPS, and TNT because of their global reliability, speed, and advanced tracking systems. Air freight ensures the fastest transit time and minimizes the impact of environmental factors on the product.
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