Name: Endomorphin-2 CAS 141801-26-5: Premium Pain Relief Peptide
Availability: InStock
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Endomorphin-2 CAS NO.141801-26-5

Endomorphin-2 is an endogenous neuropeptide featuring the sequence Tyr-Pro-Phe-Phe-NH₂, renowned for its exceptional potency and selectivity as a μ-opioid receptor (MOR) agonist. It functions as a key endogenous ligand with a distinct distribution profile, primarily localized in the spinal cord, and exhibits robust antinociceptive effects. This tetrapeptide is widely utilized in neuroscience and pharmacology research as a critical tool for investigating pain pathways, receptor signaling, and the development of novel analgesic agents.

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TECHNICAL SPECIFICATIONS

Item	Specification
Product Name	Endomorphin-2
CAS NO.	141801-26-5
Appearance	White to off-white lyophilized powder
Molecular Formula	C₃₂H₃₇N₅O₅
Molecular Weight	571.7g/mol
Purity (RP-HPLC)	≥98%
Solubility	Soluble in 1M acetic acid or DMSO
Endotoxin	≤1 EU/mg
Biological Activity	Potent and selective μ-opioid receptor (MOR) agonist
Storage Conditions	Store at -20°C, protected from light and moisture
Stock Location	Stock in USA
MOQ	1g

1.MECHANISM OF ACTION

Endomorphin-2 exerts its effects by selectively binding to μ-opioid receptors with high affinity, thereby activating G-protein coupled signaling pathways that inhibit adenylate cyclase and reduce cAMP production. This action leads to the hyperpolarization of neurons and inhibition of neurotransmitter release, effectively blocking pain signal transmission in both the central and peripheral nervous systems. Its mechanism is distinct in its ability to induce the release of other endogenous opioids like dynorphin A, contributing to its complex analgesic profile in preclinical models.

2.PRODUCT INDICATIONS

This product is strictly indicated for research use in biochemical and pharmacological studies, including receptor binding assays, signal transduction research, and in vitro functional characterization of μ-opioid receptor activity. It is particularly valuable for scientists investigating spinal cord-mediated analgesia, neuropathic pain mechanisms, and opioid receptor pharmacology. The peptide is also employed in the screening and development of new analgesic drugs and in studies exploring the physiological roles of endogenous opioid systems.

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3.CLINICAL EFFICACY OF PRODUCT

As a research-grade biochemical reagent, Endomorphin-2 is not intended for direct clinical use. Its efficacy is demonstrated in experimental settings where it serves as a potent tool for elucidating μ-opioid receptor function and pain modulation. In pre-clinical research, it has shown significant analgesic efficacy in animal models, aiding in the understanding of opioid signaling and the potential development of future therapeutics for pain management.

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4.Certificate

GlobalTech Co., Ltd. is committed to providing high-purity biotechnological peptide products, adhering strictly to quality standards and obtaining internationally recognized certifications.

Our production partners all employ GMP-compliant production systems and possess standardized quality control processes covering raw material procurement, synthesis, purification, testing, packaging, and storage. Each batch of product comes with complete documentation, including a Certificate of Analysis (COA), HPLC purity report, mass spectrometry (MS) chromatograms, and third-party testing reports available upon request.

We prioritize:

1.A rigorous quality management system

2.Batch traceability and stability data

3.Professional laboratory testing and validation

4.Compliance with international trade standards

Our commitment to quality, transparency, and regulatory compliance ensures the provision of reliable, stable, and research-grade peptide products to our global partners.

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5.DELIVERY & SHIPPING

We specialize in global logistics for various cosmetic peptides. Your order will be handled with the utmost care, ensuring safe, reliable, and intact delivery.

Professional and Secure Packaging

Each bottle of peptide is protected with a special packaging solution to ensure stability and integrity during transportation.

We can also customize packaging according to customer needs.

Shipping Methods

Main Method: International Air Freight

We primarily use DHL, FedEx, UPS, and TNT because of their global reliability, speed, and advanced tracking systems. Air freight ensures the fastest transit time and minimizes the impact of environmental factors on the product.

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Global Technology Co., Ltd. is a modern and advanced enterprise specializing in the production and export of active pharmaceutical ingredients (APIs), peptides, and plant extracts. The company invests in and collaborates closely with domestic manufacturers holding GMP, DMF, and FDA certifications, as well as laboratories at renowned universities, to meet diverse customer needs ranging from gram-level to ton-level. This enables Dejurui Pharmaceutical to provide customers with more flexible and convenient access to cost-effective, high-quality products and superior services.

We focus on the research and development and supply of high-quality chemical products, strictly adhering to international standards and quality systems. Our products are stable in performance and reliable in purity, widely used in industrial manufacturing, scientific research, and the fine chemical industry. We provide solid support at every stage with a professional and responsible attitude.

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