Name: Endothelin-1 (11-21) CAS 144602-02-8 for Advanced Research
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Endothelin-1 (11-21) CAS NO.144602-02-8

Endothelin-1 (11-21), also known as IRL-1038, is a synthetic 11-amino acid cyclic peptide fragment derived from the C-terminal region of human Endothelin-1. It features a disulfide bridge (Cys1–Cys5) that stabilizes its bioactive conformation, making it a highly selective endothelin ETB receptor antagonist. This research-grade peptide is widely used in cardiovascular and pulmonary pharmacology to dissect the distinct roles of ETB versus ETA receptors in vasoconstriction, smooth muscle contraction, and disease pathophysiology, providing a precise tool for mechanistic studies.

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TECHNICAL SPECIFICATIONS

Item	Specification
Product Name	Endothelin-1 (11-21)
CAS NO.	144602-02-8
Appearance	White to off-white lyophilized powder
Molecular Formula	C₆₈H₉₂N₁₄O₁₅S₂
Molecular Weight	1397.8g/mol
Purity (RP-HPLC)	≥98%
Solubility	Soluble in 1M acetic acid, DMSO, or deionized water
Endotoxin	≤1 EU/mg
Biological Activity	Selective endothelin ETB receptor antagonist; blocks ET-1 and ET-3 induced responses
Storage Conditions	Store at -20°C, protected from light and moisture
Stock Location	Stock in USA
MOQ	1g

1.MECHANISM OF ACTION

The peptide functions as a competitive antagonist at the endothelin ETB receptor subtype. It exhibits high affinity for ETB receptors (Ki in the nanomolar range) while showing significantly lower affinity for ETA receptors, effectively blocking ET-1 and ET-3 induced signaling through ETB. By selectively inhibiting ETB-mediated pathways, it allows researchers to isolate the physiological effects typically associated with this receptor, such as transient vasodilation (via nitric oxide release) or secondary vasoconstriction in specific vascular beds, without the confounding activation of ETA-driven sustained constriction.

2.PRODUCT INDICATIONS

This peptide is indicated for in vitro and ex vivo research applications focused on endothelin system dysregulation. It is particularly valuable for studies investigating pulmonary hypertension, systemic hypertension, renal fibrosis, and airway hyperreactivity, where ETB receptor function is implicated. Researchers in pharmacology and vascular biology utilize IRL-1038 to screen for novel endothelin antagonists, study receptor-specific responses in isolated tissue preparations (e.g., guinea pig ileum or trachea), and elucidate the role of ETB in cardiovascular and renal disease models.

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3.CLINICAL EFFICACY OF PRODUCT

Although not intended for clinical use, Endothelin-1 (11-21) has demonstrated significant efficacy in preclinical research as a proof-of-concept agent. Studies confirm its ability to potently inhibit ETB receptor-mediated contractions in smooth muscle tissues and to modulate vascular tone in experimental models of hypertension. Its selectivity and potency make it a valuable reference standard for validating the therapeutic potential of ETB receptor blockade in drug discovery pipelines targeting endothelin-dependent diseases.

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4.Certificate

GlobalTech Co., Ltd. is committed to providing high-purity biotechnological peptide products, adhering strictly to quality standards and obtaining internationally recognized certifications.

Our production partners all employ GMP-compliant production systems and possess standardized quality control processes covering raw material procurement, synthesis, purification, testing, packaging, and storage. Each batch of product comes with complete documentation, including a Certificate of Analysis (COA), HPLC purity report, mass spectrometry (MS) chromatograms, and third-party testing reports available upon request.

We prioritize:

1.A rigorous quality management system

2.Batch traceability and stability data

3.Professional laboratory testing and validation

4.Compliance with international trade standards

Our commitment to quality, transparency, and regulatory compliance ensures the provision of reliable, stable, and research-grade peptide products to our global partners.

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5.DELIVERY & SHIPPING

We specialize in global logistics for various cosmetic peptides. Your order will be handled with the utmost care, ensuring safe, reliable, and intact delivery.

Professional and Secure Packaging

Each bottle of peptide is protected with a special packaging solution to ensure stability and integrity during transportation.

We can also customize packaging according to customer needs.

Shipping Methods

Main Method: International Air Freight

We primarily use DHL, FedEx, UPS, and TNT because of their global reliability, speed, and advanced tracking systems. Air freight ensures the fastest transit time and minimizes the impact of environmental factors on the product.

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Global Technology Co., Ltd. is a modern and advanced enterprise specializing in the production and export of active pharmaceutical ingredients (APIs), peptides, and plant extracts. The company invests in and collaborates closely with domestic manufacturers holding GMP, DMF, and FDA certifications, as well as laboratories at renowned universities, to meet diverse customer needs ranging from gram-level to ton-level. This enables Dejurui Pharmaceutical to provide customers with more flexible and convenient access to cost-effective, high-quality products and superior services.

We focus on the research and development and supply of high-quality chemical products, strictly adhering to international standards and quality systems. Our products are stable in performance and reliable in purity, widely used in industrial manufacturing, scientific research, and the fine chemical industry. We provide solid support at every stage with a professional and responsible attitude.

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